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Clozapine-induced electroencephalogram changes as a function of clozapine serum levels.

Author: FreudenreichO, McEvoyJ P, WeinerR D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Clozapine therapy was found to cause EEG changes in 53% of patients with schizophrenia. 6% of patients experienced seizures, 13% developed spikes, and 53% developed slowing. Higher clozapine serum levels (350-450 ng/mL) led to more frequent and severe slowing compared to lower levels.
Paper Details　
Original Abstract of the Article :
Specific electroencephalogram (EEG) changes during clozapine therapy were prospectively studied in a cohort of 50 chronic state hospital patients with schizophrenia who were randomly assigned to one of three nonoverlapping clozapine serum level ranges (50-150 ng/mL, 200-300 ng/mL, and 350-450 ng/mL)...See full text at original site
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引用元：
https://doi.org/10.1016/S0006-3223(96)00298-3

データ提供：米国国立医学図書館（NLM）

Clozapine: Impact on Electroencephalogram (EEG) and Serum Levels

Clozapine, an atypical antipsychotic medication, is often prescribed for individuals with schizophrenia. While effective in managing symptoms, it can have potential side effects, including changes in brain activity. This research investigates the relationship between clozapine serum levels and electroencephalogram (EEG) changes in patients with schizophrenia. The researchers conducted a prospective study involving 50 patients who were randomly assigned to different clozapine serum level ranges. The study found that clozapine therapy was associated with EEG changes, including slowing and spikes. The severity of EEG slowing correlated with the observed sleepiness, suggesting a dose-dependent effect. The findings highlight the importance of monitoring EEG changes during clozapine therapy and adjusting treatment accordingly.

Understanding Clozapine's Impact on Brain Activity: Insights from EEG Changes

This study sheds light on the potential impact of clozapine therapy on brain activity, as evidenced by EEG changes. The findings highlight the importance of monitoring EEG patterns during clozapine treatment, especially in patients experiencing increased sleepiness or other neurological symptoms. The research provides valuable insights into the dose-dependent effects of clozapine and the need for careful monitoring and adjustment of treatment to minimize potential adverse effects.

Navigating the Complexities of Antipsychotic Therapy: Balancing Benefits and Risks

This study highlights the complexities of antipsychotic therapy, specifically with clozapine. While clozapine can be effective in managing symptoms of schizophrenia, it's crucial to be aware of its potential side effects, including changes in brain activity as reflected by EEG patterns. This study underscores the importance of careful monitoring, dose adjustments, and individualized treatment plans to optimize treatment outcomes and minimize potential risks.

Dr.Camel's Conclusion

This study offers valuable insights into the relationship between clozapine serum levels and EEG changes in patients with schizophrenia. The findings emphasize the importance of monitoring EEG patterns during clozapine treatment and adjusting treatment accordingly. This research highlights the need for careful consideration of potential side effects and individualized treatment plans to optimize treatment outcomes and minimize potential risks associated with clozapine therapy.

Date :
  1. Date Completed 1997-08-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9209730

DOI: Digital Object Identifier

10.1016/S0006-3223(96)00298-3

SNS
PICO Info
in preparation
Languages

English

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