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Effects of inhaled corticosteroids on bone.

Author: BootsmaG P, DekhuijzenP N, FestenJ, van HerwaardenC L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Inhaled corticosteroids (ICS) are effective for asthma treatment, but concerns exist regarding potential systemic effects, particularly on bone. While some studies suggest decreases in bone density, the clinical relevance of these findings is unknown.
Paper Details　
Original Abstract of the Article :
Inhaled corticosteroids (ICS) are the most effective therapy for asthma currently available. The increasing use of ICS raises the issue of possible adverse systemic effects. Since one of the most important side-effects of oral corticosteroids (OCS) is osteoporosis, this article focuses on current kn...See full text at original site
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引用元：
https://doi.org/10.1016/s0300-2977(97)00028-4

データ提供：米国国立医学図書館（NLM）

Inhaled Corticosteroids: Navigating the Complex Landscape of Bone Health

Inhaled corticosteroids (ICS), like a refreshing oasis in the desert, have revolutionized the treatment of asthma. However, like any powerful remedy, ICS use may come with potential side effects. This study investigates the effects of ICS on bone health, focusing on the potential for bone loss and the clinical implications of these findings.

The Bone Connection: Understanding ICS's Impact on Bone Health

The study acknowledges the dose-dependent decrease in serum osteocalcin levels associated with high doses of ICS. While some studies have suggested potential decreases in bone density with ICS use, the researchers emphasize the difficulty in isolating the specific contribution of ICS from other confounding factors. The clinical relevance of these observations in the long term remains unclear, and further research is needed to definitively assess the impact of ICS on fracture risk.

A Balancing Act: Optimizing Asthma Treatment While Protecting Bone Health

This research underscores the importance of a balanced approach to asthma treatment, prioritizing the use of the lowest effective dose of ICS to minimize potential side effects. Clinicians should carefully monitor bone health in patients receiving ICS therapy, particularly those at increased risk for osteoporosis. The study highlights the need for continued research to better understand the long-term impact of ICS on bone health.

Dr. Camel's Conclusion

This study, like a camel caravan cautiously navigating a desert landscape, explores the complex relationship between inhaled corticosteroids and bone health. While ICS offer a valuable tool for asthma management, the research highlights the importance of careful consideration of potential side effects. By prioritizing the lowest effective dose and monitoring bone health, clinicians can effectively manage asthma while mitigating potential risks to bone health, ensuring a balanced and safe approach to patient care.

Date :
  1. Date Completed 1997-08-19
  2. Date Revised 2019-11-02
Further Info :

Pubmed ID

9232092

DOI: Digital Object Identifier

10.1016/s0300-2977(97)00028-4

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Languages

English

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