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Effects of valacyclovir in cats infected with feline herpesvirus 1.

Author: DormanD C, HawkinsE C, JamisonK C, NasisseM P, StevensJ B, WeiglerB J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Valacyclovir was found to be toxic to cats with primary feline herpesvirus 1 (FHV-1) infection, even at high doses, and did not suppress viral replication.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine whether orally administered valacyclovir can be used safely and effectively to treat cats with primary, feline herpesvirus 1 (FHV-1) infection. ANIMALS: 14 specific-pathogen-free adult cats. PROCEDURE: Cats were infected with FHV-1 strain 87-727 (300 microliters, 10(7) plaq...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9328668

データ提供：米国国立医学図書館（NLM）

Valacyclovir and Feline Herpesvirus 1: A Cautionary Tale

This study delves into the intriguing world of feline herpesvirus 1 (FHV-1) and the effects of valacyclovir, an antiviral medication commonly used to treat herpes infections. It’s like exploring a hidden cave system in the desert, where we uncover unexpected discoveries and potential dangers.

Valacyclovir’s Unexpected Toxicity in Cats

The study revealed that valacyclovir, while effective in treating herpes in humans, was surprisingly toxic to cats. It caused adverse effects like lethargy, dehydration, and bone marrow suppression. This discovery is like finding a beautiful desert flower that is also poisonous. It’s important to approach new discoveries with caution.

The Challenge of Treating FHV-1

The study also showed that even high doses of valacyclovir did not effectively suppress FHV-1 replication in cats. This poses a challenge for treating feline herpesvirus infections. It’s like trying to find a reliable source of water in a desert that is constantly shifting and changing.

Dr.Camel's Conclusion

This research reminds us that what works for one species may not work for another. It underscores the importance of careful and thorough testing before introducing new medications, even those already proven effective in other species. It’s a reminder that the desert of medical knowledge is vast and complex, and we must always be mindful of the potential for unexpected discoveries and challenges.

Date :
  1. Date Completed 1997-12-31
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

9328668

DOI: Digital Object Identifier

9328668

Related Literature

Article Analysis
・Effects of valacyclovir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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