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Coadministration of tamsulosin and three antihypertensive agents in patients with benign prostatic hyperplasia: pharmacodynamic effect.

Author: LoweF C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the effects of tamsulosin on the pharmacodynamic profiles of nifedipine, enalapril, and atenolol in hypertensive men. Tamsulosin did not have clinically significant effects on the blood pressure or pulse rate of patients taking these antihypertensive medications.
Paper Details　
Original Abstract of the Article :
Tamsulosin, an alpha 1A-adrenoceptor antagonist, has recently been approved to treat patients with symptomatic benign prostatic hyperplasia (BPH). Tamsulosin is highly selective for prostatic receptors with minimal affinity for vascular receptors. Therefore, it should have little effect on blood pre...See full text at original site
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引用元：
https://doi.org/10.1016/s0149-2918(97)80097-5

データ提供：米国国立医学図書館（NLM）

Coadministration of Tamsulosin and Antihypertensive Agents in Benign Prostatic Hyperplasia

This research navigates the complex terrain of medication interactions, a territory that can be as unpredictable as a desert oasis with shifting sands. The researchers explored the effects of combining tamsulosin, a drug used to treat benign prostatic hyperplasia (BPH), with various antihypertensive medications, like finding a combination of desert plants that can provide both shade and nourishment.

Finding Harmony in the Desert of Medications: Tamsulosin and Antihypertensive Combinations

The study found that coadministration of tamsulosin with nifedipine, enalapril, and atenolol did not have any clinically significant effects on blood pressure or heart rate. This is like discovering that different desert plants can be combined without causing any adverse effects, allowing for a more balanced and effective use of resources. The researchers concluded that tamsulosin can be safely coadministered with these antihypertensive agents, providing relief for both BPH and high blood pressure without additional risks.

The Desert Oasis of Medication Management: Finding the Right Balance

This research emphasizes the importance of careful consideration when combining medications. By understanding the potential interactions between different drugs, healthcare professionals can create treatment plans that are both effective and safe. Like a skilled desert traveler who knows how to use various resources to their advantage, healthcare professionals can navigate the complex world of medications with expertise and precision.

Dr.Camel's Conclusion

This research highlights the crucial role of careful medication management in maintaining overall health. Like a desert oasis that provides sustenance and protection, proper medication management can help individuals maintain a balanced and healthy state, ensuring their journey through life is as comfortable and fulfilling as possible.
Date :
  1. Date Completed 1997-11-12
  2. Date Revised 2019-09-20
Further Info :

Pubmed ID

9377617

DOI: Digital Object Identifier

10.1016/s0149-2918(97)80097-5

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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