Effects of tamsulosin: A Synthesis of Findings from 7 Studies

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Original Abstract of the Article

Major Research Findings

A study ( 6 ) found that combining tamsulosin with tadalafil daily significantly reduced detrusor pressure at maximum flow, a measure of bladder pressure during urination, without affecting the maximum flow rate. This combination also showed a significant improvement in lower urinary tract symptoms compared to using tamsulosin alone.

Another study ( 3 ) highlighted the potential benefits of combining alpha-blockers (like tamsulosin) with PDE-5 inhibitors (like tadalafil) for men experiencing both lower urinary tract symptoms and erectile dysfunction (ED). The study indicated that PDE-5 inhibitors have a beneficial effect on lower urinary tract symptoms while highlighting the potential for alpha-blockers to cause erectile dysfunction, particularly tamsulosin which can lead to anejaculation.

Further research is needed to fully explore the potential advantages of this combination therapy.

Benefits and Risks

Benefit Summary

Combining tamsulosin with tadalafil has shown potential benefits in improving lower urinary tract symptoms, such as frequent urination, difficulty urinating, and a feeling of incomplete bladder emptying. 6 demonstrated significant improvement in lower urinary tract symptom scores in men who received this combination therapy compared to those who received tamsulosin alone.

Risk Summary

Tamsulosin, an alpha-blocker, is associated with an increased risk of erectile dysfunction (ED) and ejaculatory dysfunction. 3 noted that tamsulosin can lead to anejaculation. It's important to discuss these potential side effects with your doctor.

Study Comparisons

Study Commonalities

Multiple studies have demonstrated the potential benefits of combining tamsulosin with tadalafil for improving lower urinary tract symptoms. 6 , 3

Study Differences

There are differences in the reported severity of erectile dysfunction (ED) associated with tamsulosin. While 3 suggested that tamsulosin can contribute to ED, 1 suggested that tamsulosin might have a lower risk of causing ED compared to other alpha-blocking agents. Further research is needed to clarify these findings.

Consistency and Discrepancies

While research indicates the potential for tamsulosin to contribute to erectile dysfunction, 1 suggested a lower risk compared to other alpha-blockers. More research is needed to fully understand these findings.

Real-World Application Notes

While combining tamsulosin with tadalafil may be beneficial for improving lower urinary tract symptoms, it is crucial to be aware of the potential side effects, including erectile dysfunction (ED) and ejaculatory problems. Consult with your doctor to discuss these potential risks and make informed decisions about your treatment.

Current Study Limitations

The research on combining tamsulosin with tadalafil is still limited. More studies are needed to determine the long-term safety and effectiveness of this combination.

Future Research Directions

Large-scale clinical trials are needed to evaluate the long-term safety and effectiveness of combining tamsulosin with tadalafil, and to determine the optimal dosage for this combination therapy.

Conclusion

Combining tamsulosin with tadalafil shows promise for improving lower urinary tract symptoms, but it is essential to consider the potential side effects of erectile dysfunction (ED) and ejaculatory problems. Consultation with a doctor is vital for a personalized treatment plan that balances benefits and risks.

Literature analysis of 7 papers
Positive Content
7
Neutral Content
0
Negative Content
0
Article Type
6
1
0
1
7
1.

Coadministration of tamsulosin and three antihypertensive agents in patients with benign prostatic hyperplasia: pharmacodynamic effect.

Author: LoweF C

No blood pressure impact
Treats BPH

This study evaluated the effects of tamsulosin on the pharmacodynamic profiles of nifedipine, enalapril, and atenolol in hypertensive men. Tamsulosin did not have clinically significant effects on the blood pressure or pulse rate of patients taking these antihypertensive medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Simultaneous administration of vardenafil and tamsulosin does not induce clinically significant hypotension in patients with benign prostatic hyperplasia.

Author: AuerbachStephen M, GittelmanMarc, MazzuArthur, CihonFrank, SundaresanPavur, WhiteWilliam B

BPH treatment
Dizziness

Coadministered vardenafil and tamsulosin did not induce clinically significant hypotension in patients with benign prostatic hyperplasia (BPH).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Lower urinary tract symptoms and sexual dysfunction: a common approach.

Author: GiulianoFrançois

ED treatment
LUTS treatment

Alpha-blockers, a class of drugs used to treat an enlarged prostate, and PDE-5 inhibitors, a class of drugs used to treat erectile dysfunction, may be effective when used together. These medications work in different ways to relax muscles in the prostate and bladder, as well as the penis. Further research is needed to confirm the benefits of combining these medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

The effects of dutasteride or tamsulosin alone and in combination on storage and voiding symptoms in men with lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH): 4-year data from the Combination of Avodart and Tamsulosin (CombAT) study.

Author: MontorsiFrancesco, RoehrbornClaus, Garcia-PenitJavier, BorreMichael, RoeleveldTon A, AlimiJean-Charles, GagnierPaul, WilsonTimothy H

LUTS Control

Combined therapy with dutasteride plus tamsulosin provided better long-term control of both storage and voiding lower urinary tract symptoms (LUTS) compared with tamsulosin monotherapy in men with a prostate volume of ≥ 30 mL. Combined therapy was better than dutasteride monotherapy in men with prostate volumes of ≥ 30 to < 58 mL, but not in men with a prostate volume of ≥ 58 mL.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Non-inferiority of silodosin to tamsulosin in treating patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).

Author: YuHong-Jeng, LinAlex Tong-Long, YangStephen Shei-Dei, TsuiKe-Hung, WuHsi-Chin, ChengChen-Li, ChengHong-Lin, WuTony T, ChiangPo-Hui

LUTS treatment
Cardiovascular side effects

This study compared the efficacy and side effects of silodosin and tamsulosin in treating patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Silodosin administered by 4 mg twice daily was as effective as tamsulosin 0.2 mg daily in treating patients with LUTS associated with BPH. Relative to tamsulosin, silodosin has less cardiovascular side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Urodynamic effects of the combination of tamsulosin and daily tadalafil in men with lower urinary tract symptoms secondary to benign prostatic hyperplasia: a randomized, placebo-controlled clinical trial.

Author: RegadasRommel Prata, RegesRicardo, CerqueiraJoão Batista Gadelha, SucupiraDaniel Gabrielle, JosinoIatagan Rocha, NogueiraEmmanuel Almeida, JamacaruFrancisco Vagnaldo F, de MoraesManoel Odorico, SilvaLúcio Flávio Gonzaga

Tamsulosin/tadalafil improves LUT symptoms

The association of tamsulosin/tadalafil reduces detrusor pressure at maximum flow without changing the maximum flow rate during micturition and significantly improves lower urinary tract symptoms compared with the isolated use of tamsulosin.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Absence of clinically relevant cardiovascular interaction upon add-on of mirabegron or tamsulosin to an established tamsulosin or mirabegron treatment in healthy middle-aged to elderly men.

Author: van GelderenMarcel, TretterReiner, MeijerJohn, DorrepaalCaroline, Gangaram-PandayShanti, BrooksAshley, KrauwinkelWalter, DickinsonJames

No clinically relevant changes

Co-treatment with tamsulosin and mirabegron did not result in clinically relevant changes in cardiovascular safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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