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Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women.

Author: BjarnasonN H, ChristiansenC, DelmasP D, DraperM, HusterW J, MitlakB H, RavouxA C, ShahA S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Raloxifene, a nonsteroidal benzothiophene, significantly increased bone mineral density and lowered serum concentrations of total and low-density lipoprotein cholesterol in postmenopausal women, without stimulating the endometrium.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Long-term estrogen therapy can reduce the risk of osteoporotic fracture and cardiovascular disease in postmenopausal women. At present, however, these beneficial effects are not separable from undesirable stimulation of breast and endometrial tissues. METHODS: We studied the effect of r...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM199712043372301

データ提供：米国国立医学図書館（NLM）

Raloxifene: A Bone-Building, Cholesterol-Lowering Wonder

Estrogen therapy has long been recognized for its benefits in preventing osteoporosis and cardiovascular disease in postmenopausal women. However, its use is often limited due to the risk of stimulating breast and endometrial tissues. This research investigates the effects of raloxifene, a nonsteroidal benzothiophene, on bone mineral density, serum lipid concentrations, and endometrial thickness in postmenopausal women.

Raloxifene: A Safe and Effective Alternative

The study, a randomized controlled trial involving 601 women, reveals that raloxifene effectively increases bone mineral density, lowers serum cholesterol levels, and does not stimulate the endometrium. These findings suggest that raloxifene offers a safe and effective alternative to estrogen therapy for postmenopausal women, addressing multiple health concerns.

A Powerful Tool for Preventing Osteoporosis and Cardiovascular Disease

This research highlights the potential of raloxifene as a powerful tool for preventing osteoporosis and reducing the risk of cardiovascular disease in postmenopausal women, without the risks associated with estrogen therapy. The study emphasizes the importance of personalized healthcare and considering the individual needs and risks of each patient.

Dr.Camel's Conclusion

Just as camels are known for their endurance and resilience in the desert, raloxifene offers a robust approach to managing the health challenges faced by postmenopausal women. This research provides valuable insight into the potential benefits of raloxifene for preventing osteoporosis, reducing cardiovascular risk, and offering a safe alternative to estrogen therapy. This study is a testament to the tireless efforts of researchers striving to improve the lives of women and enhance their well-being.

Date :
  1. Date Completed 1997-12-04
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

9385122

DOI: Digital Object Identifier

10.1056/NEJM199712043372301

SNS
PICO Info
in preparation
Languages

English

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