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The effects of epsilon-aminocaproic acid on fibrinolysis and thrombin generation during cardiac surgery.

Author: FaghihF, GreenbergC S, LeslieJ B, SladenR N, SlaughterT F

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Epsilon-aminocaproic acid (EACA) was found to significantly decrease fibrinolytic activity and bleeding in 41 patients undergoing primary coronary artery bypass graft surgery. However, it did not reduce thrombin generation, suggesting a potential risk of hypercoagulation.
Paper Details　
Original Abstract of the Article :
Despite the efficacy of antifibrinolytic drugs in reducing bleeding after cardiac surgery, concerns remain regarding their potential to promote thrombosis. We examined the effect of the antifibrinolytic drug, epsilon-aminocaproic acid (EACA) on fibrinolysis and thrombin generation during cardiac sur...See full text at original site
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引用元：
https://doi.org/10.1097/00000539-199712000-00008

データ提供：米国国立医学図書館（NLM）

Balancing Bleeding and Thrombosis: The Role of Epsilon-Aminocaproic Acid

The human body is a delicate balance of forces, and maintaining equilibrium is crucial for optimal health. This study explores the role of epsilon-aminocaproic acid (EACA), an antifibrinolytic drug, in cardiac surgery. The researchers aimed to investigate the effect of EACA on fibrinolysis (the breakdown of blood clots) and thrombin generation (the formation of blood clots) during cardiac surgery. They conducted a randomized controlled trial to compare the effects of EACA with saline in a group of patients undergoing coronary artery bypass graft surgery. The results showed that EACA significantly decreased fibrinolytic activity, leading to reduced bleeding. However, it did not affect thrombin generation. This raises concerns that EACA might potentially increase the risk of thrombosis, a condition where blood clots form in the blood vessels.

A Balancing Act: Managing Bleeding and Thrombosis

The findings of this study emphasize the complex nature of managing bleeding and thrombosis in surgical settings. While EACA can effectively reduce bleeding, its potential to promote thrombosis needs careful consideration. Further research is necessary to explore strategies for minimizing these risks and optimizing patient outcomes.

Navigating the Complexities of Blood Coagulation

The study underscores the delicate balance between bleeding and thrombosis. Understanding the intricate mechanisms of blood coagulation is vital for making informed decisions about medication and surgical procedures. This knowledge can help medical professionals minimize risks and optimize patient care.

Dr.Camel's Conclusion

EACA effectively reduces bleeding after cardiac surgery but may potentially increase the risk of thrombosis. This research highlights the need for a nuanced approach to managing blood coagulation during surgery, balancing the benefits of reducing bleeding with the risk of promoting blood clots.
Date :
  1. Date Completed 1997-12-19
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

9390584

DOI: Digital Object Identifier

10.1097/00000539-199712000-00008

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PICO Info
in preparation
Languages

English

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