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Trypanocidal effects of promethazine.

Author: FernándezA R, FretesR, LacuaraJ L, Paglini-OlivaP, RubialesS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that promethazine has trypanocidal effects against both epimastigote and trypomastigote stages of T. cruzi, the parasite that causes Chagas disease. Promethazine was effective in reducing parasitemia and increasing survival in infected mice.
Paper Details　
Original Abstract of the Article :
Promethazine is currently used for its antipsychotic and ansiolytic effects. It is a phenothiazine with anticalmodulin action, not toxic for human beings at therapeutic doses. The present results show that promethazine has trypanocidal effect on both epimastigote and trypomastigote stages of T. cruz...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9435371

データ提供：米国国立医学図書館（NLM）

Promethazine: A Hidden Oasis in the Desert of Chagas Disease

Chagas disease, a parasitic infection that can have devastating consequences, is like a relentless sandstorm, threatening the lives of those infected. This study explores the trypanocidal effects of promethazine, a medication typically used for its antipsychotic and anxiolytic properties, exploring its potential as a hidden oasis in the desert of Chagas disease treatment. The researchers investigated the effectiveness of promethazine against different stages of the parasite, from epimastigotes to trypomastigotes, examining its potential to combat this challenging disease.

A Promising Weapon in the Desert of Chagas

The study's findings demonstrate the trypanocidal activity of promethazine, suggesting its potential as a valuable weapon in the fight against Chagas disease. This medication, often known for its antipsychotic and anxiolytic effects, emerges as a potential oasis in the desert of Chagas treatment, offering a promising avenue for combating this debilitating infection. The researchers observed a reduction in parasitemia and increased survival in infected mice treated with promethazine, highlighting its potential for therapeutic intervention in this challenging disease.

Navigating the Desert of Chagas Disease

The study's insights offer a roadmap for navigating the desert of Chagas disease treatment. Promethazine, a medication with a broader therapeutic profile, emerges as a potential oasis in this challenging landscape, offering a promising avenue for managing this parasitic infection. However, as with any journey through the desert, careful monitoring and individualized care are crucial to ensure safe and effective treatment.

Dr. Camel's Conclusion

Chagas disease, a formidable adversary, can leave patients lost in a desert of illness. This study reveals the potential of promethazine, a medication often used for its antipsychotic and anxiolytic effects, as a hidden oasis in the desert of Chagas disease treatment. By understanding its trypanocidal activity, researchers and healthcare providers can explore new strategies to combat this debilitating infection and offer patients a chance to find their way back to health.

Date :
  1. Date Completed 1998-04-07
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9435371

DOI: Digital Object Identifier

9435371

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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