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Isradipine and naltrexone in combination with isradipine interact with a period of abstinence to reduce rats' intakes of an alcoholic beverage.

Author: BoedekerK L, GardellL R, HubbellC L, LiakosT M, ReidL D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study found that combining isradipine and naltrexone was more effective than either drug alone in reducing ethanol intake in rats. This combination was also associated with fewer side effects. This finding suggests that this combination may be a promising treatment for alcohol dependence.
Paper Details　
Original Abstract of the Article :
Individually housed rats were placed on a daily regimen of only 2 hr a day to drink both water and a sweetened alcoholic beverage. Initially, rats took little ethanol, but after 3 weeks, they took, on average, >2.0 g/kg daily. With achievement of stable intakes, the rats were deprived of opportunity...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9438517

データ提供：米国国立医学図書館（NLM）

Isradipine and Naltrexone: A New Approach to Alcoholism Treatment

This research investigates the potential of isradipine and naltrexone, two medications, to reduce alcohol intake in rats. It's like observing a herd of camels in the desert, trying to understand their behavior and find ways to influence their actions. The authors are exploring new avenues to help people with alcoholism, seeking a path to recovery in the vast desert of addiction.

A New Oasis of Hope: Combined Medication Therapy

The study found that a combination of isradipine and naltrexone was more effective in reducing alcohol intake than either medication alone. It's like discovering a new oasis in the desert, offering a haven for those struggling with addiction. This research offers a promising new approach to alcoholism treatment.

Finding Your Way Back: Treatment and Recovery

This study underscores the importance of finding the right treatment for alcoholism. It's like navigating a desert with many paths, each leading to a different destination. The authors have discovered a new path that may lead to recovery for many individuals. It's a reminder that with persistent research and innovation, we can find new solutions to the complex challenges of addiction.

Dr.Camel's Conclusion

This study explores the potential of isradipine and naltrexone in combination as a promising new approach to treating alcoholism. It's like finding a new oasis in the desert, offering a path to recovery for those struggling with addiction. The research highlights the importance of continued research and innovation in the fight against alcoholism.

Date :
  1. Date Completed 1998-02-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9438517

DOI: Digital Object Identifier

00000374-199712000-00006

Related Literature

Article Analysis
・Side Effects of isradipine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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