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Estrogen therapy in postmenopausal women: effects on cognitive function and dementia.

Author: GradyD, LieberburgI, SawayaG, YaffeK

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

While estrogen replacement therapy may potentially benefit cognition, prevent dementia, and improve dementia severity, there is conflicting evidence and large, placebo-controlled trials are needed to confirm its effectiveness.
Paper Details　
Original Abstract of the Article :
CONTEXT: Several studies have suggested that estrogen replacement therapy in postmenopausal women improves cognition, prevents development of dementia, and improves the severity of dementia, while other studies have not found a benefit of estrogen use. OBJECTIVE: To determine whether postmenopausal...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1001/jama.279.9.688

データ提供：米国国立医学図書館（NLM）

Estrogen Therapy in Postmenopausal Women: Effects on Cognition

The desert of menopause can be a time of significant hormonal shifts, with potential implications for cognitive function and the risk of dementia. This review explores the potential benefits and risks of estrogen replacement therapy (ERT) in postmenopausal women. The study examines the research on the effects of estrogen on cognition and dementia, highlighting the complex and often contradictory findings. The review emphasizes the need for large-scale, placebo-controlled trials to definitively determine the role of ERT in preventing or treating dementia.

Estrogen Therapy: A Complex and Contentious Topic

The findings highlight the need for caution and further research before recommending ERT for the prevention or treatment of dementia. The study underscores the importance of weighing the potential benefits against the known risks of ERT and making informed decisions based on individual patient needs and preferences.

Navigating the Desert of Menopause: A Patient's Perspective

As a woman navigating the desert of menopause, understanding the potential effects of ERT on your cognitive health is essential. This review provides valuable insights into the complex and often contradictory research on this topic, emphasizing the importance of open communication with your healthcare team and making informed decisions based on your individual needs and goals.

Dr. Camel's Conclusion

The desert of menopause can be a challenging terrain. This review sheds light on the complex and often contradictory research on the effects of estrogen therapy on cognitive function and dementia. The study highlights the importance of careful consideration and ongoing research to fully understand the role of ERT in managing cognitive health during menopause.

Date :
  1. Date Completed 1998-03-11
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

9496988

DOI: Digital Object Identifier

10.1001/jama.279.9.688

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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