Experimental odontogenic cysts induced by in vitro 4-nitroquinoline 1-oxide (4NQO) treatment of F344 rat incisor tooth germs.

Author: KitanoM, LiT J, MiuraY, OzakiH S, UemuraM

Paper Details 
Original Abstract of the Article :
This study was designed to establish an experimental animal model for elucidating the early stages of odontogenic cysts and tumors. It involves the in vitro treatment of tooth germs with 4-nitroquinoline 1-oxide (4NQO) at the early bell stage and their subsequent transplantation into the kidney subc...See full text at original site
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引用元:
https://doi.org/10.1111/j.1600-0714.1998.tb02093.x

データ提供:米国国立医学図書館(NLM)

Unveiling the Secrets of Odontogenic Cysts: An Experimental Model

The [study of odontogenic cysts and tumors] is a challenging terrain, where researchers must navigate the complexities of [dental development] and the potential for disease. This study, like a skilled archaeologist, sought to establish an experimental model for understanding the early stages of [odontogenic cysts]. Their approach involved [in vitro treatment of tooth germs with 4-nitroquinoline 1-oxide (4NQO)] at the early bell stage followed by [transplantation into the kidney subcapsular space]. They found that, much like a seed sprouting in the desert, 4NQO-treated tooth germs developed into [keratinized cysts] with or without associated tooth structures. This finding provides a valuable tool for further research into the origins and development of these cysts.

A New Frontier: An Experimental Model for Odontogenic Cysts

The study successfully established an experimental model for investigating [odontogenic cysts]. By using [4NQO-treated tooth germs], they were able to induce the development of [keratinized cystic lesions] that share similarities with human [odontogenic keratocysts] or [primordial cysts]. This discovery, like a newly charted oasis, opens up exciting possibilities for future research in this area.

Understanding the Desert of Oral Disease: A Step Forward in Research

This study provides a valuable tool for understanding the [development of odontogenic cysts]. By creating a controllable environment for observing the formation of these cysts, researchers can gain valuable insights into the underlying mechanisms and explore potential therapeutic strategies. Just as a camel adapts to the harsh desert environment, our understanding of oral diseases must continually evolve to provide better care for patients.

Dr.Camel's Conclusion

This research provides a valuable tool for unraveling the mysteries of odontogenic cysts. Just as a skilled explorer carefully analyzes the landscape, researchers can now delve deeper into the development of these cysts, paving the way for new treatments and prevention strategies.

Date :
  1. Date Completed 1998-05-19
  2. Date Revised 2019-09-14
Further Info :

Pubmed ID

9526729

DOI: Digital Object Identifier

10.1111/j.1600-0714.1998.tb02093.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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