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Original Abstract of the Article :
Variability in drug metabolism is an important factor that accounts for individual responsiveness to xenobiotics. Enzyme induction which leads to a more rapid elimination of foreign compounds and to a more extensive formation of potentially active metabolites significantly contributes to large inter...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s002280050412
データ提供:米国国立医学図書館(NLM)
Ethanol's Inductive Potential: Clinical and Toxicological Consequences
This research explores the complex effects of ethanol, a widely consumed substance, on drug metabolism. The study focuses on the inductive potential of ethanol, examining its ability to increase the activity of certain enzymes involved in drug metabolism. The researchers investigated the clinical and toxicological implications of this inductive effect.
Ethanol: A Double-Edged Sword in Drug Metabolism
The study highlights the influence of ethanol consumption on drug metabolism, emphasizing the importance of considering this factor when prescribing medications. Ethanol can induce the activity of certain enzymes, particularly CYP2E1, leading to accelerated metabolism of specific drugs. This can result in decreased drug efficacy or increased formation of potentially toxic metabolites. It's like adding a powerful catalyst to a chemical reaction, altering the course of drug metabolism and potentially impacting the effectiveness or safety of medications.
Ethanol and Drug Interactions: A Need for Caution
This research underscores the importance of taking a comprehensive history of ethanol consumption when assessing drug disposition and action. It emphasizes the potential for drug interactions and adverse effects associated with ethanol's inductive potential. As we navigate the complex desert of drug metabolism, we must be mindful of the potential interactions and consequences of ethanol consumption.
Dr. Camel's Conclusion
This study emphasizes the importance of understanding the complex interplay between ethanol consumption and drug metabolism. It highlights the need for caution and careful consideration of potential interactions to ensure patient safety and optimize therapeutic outcomes. Just as a camel must adapt to the changing sands of the desert, we must adapt our medical practices to account for the influence of ethanol on drug metabolism.
Date :
- Date Completed 1998-06-11
- Date Revised 2019-08-13
Further Info :
Related Literature
English
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