Clinical and toxicological consequences of the inductive potential of ethanol.

Author: AmmonE, KlotzU

Paper Details 
Original Abstract of the Article :
Variability in drug metabolism is an important factor that accounts for individual responsiveness to xenobiotics. Enzyme induction which leads to a more rapid elimination of foreign compounds and to a more extensive formation of potentially active metabolites significantly contributes to large inter...See full text at original site
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引用元:
https://doi.org/10.1007/s002280050412

データ提供:米国国立医学図書館(NLM)

Ethanol's Inductive Potential: Clinical and Toxicological Consequences

This research explores the complex effects of ethanol, a widely consumed substance, on drug metabolism. The study focuses on the inductive potential of ethanol, examining its ability to increase the activity of certain enzymes involved in drug metabolism. The researchers investigated the clinical and toxicological implications of this inductive effect.

Ethanol: A Double-Edged Sword in Drug Metabolism

The study highlights the influence of ethanol consumption on drug metabolism, emphasizing the importance of considering this factor when prescribing medications. Ethanol can induce the activity of certain enzymes, particularly CYP2E1, leading to accelerated metabolism of specific drugs. This can result in decreased drug efficacy or increased formation of potentially toxic metabolites. It's like adding a powerful catalyst to a chemical reaction, altering the course of drug metabolism and potentially impacting the effectiveness or safety of medications.

Ethanol and Drug Interactions: A Need for Caution

This research underscores the importance of taking a comprehensive history of ethanol consumption when assessing drug disposition and action. It emphasizes the potential for drug interactions and adverse effects associated with ethanol's inductive potential. As we navigate the complex desert of drug metabolism, we must be mindful of the potential interactions and consequences of ethanol consumption.

Dr. Camel's Conclusion

This study emphasizes the importance of understanding the complex interplay between ethanol consumption and drug metabolism. It highlights the need for caution and careful consideration of potential interactions to ensure patient safety and optimize therapeutic outcomes. Just as a camel must adapt to the changing sands of the desert, we must adapt our medical practices to account for the influence of ethanol on drug metabolism.

Date :
  1. Date Completed 1998-06-11
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

9591923

DOI: Digital Object Identifier

10.1007/s002280050412

Related Literature

SNS
PICO Info
in preparation
Languages

English

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