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Adequate relief as an endpoint in clinical trials in irritable bowel syndrome.

Author: DukesG E, HahnB A, HeathA T, KongS, MangelA W, McSorleyD, NorthcuttA R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that patients’ perception of adequate pain relief in irritable bowel syndrome (IBS) is a good indicator of overall improvement. In a study of 370 people with IBS, adequate pain relief was associated with a reduction in pain severity, fewer pain-free days, fewer days with urgency, improved bowel frequency and consistency, and better quality of life. This suggests that adequate pain relief can be used as a key measure of treatment effectiveness in IBS.
Paper Details　
Original Abstract of the Article :
Irritable bowel syndrome is characterized by recurrent abdominal pain and altered bowel function. In designing studies to evaluate new treatments for this disease, however, it is difficult to select appropriate endpoints to reflect improvement in the range of symptoms of the syndrome. In the present...See full text at original site
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引用元：
https://doi.org/10.1177/030006059802600203

データ提供：米国国立医学図書館（NLM）

Adequate Relief as an Endpoint in Clinical Trials in Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a common and often frustrating condition that can significantly impact a person's quality of life. This study addresses the challenge of finding effective endpoints in clinical trials for IBS, The authors propose using the concept of 'adequate relief' as a key endpoint to assess the effectiveness of new treatments, based on the patient's perception of symptom improvement.

A New Oasis in the Desert of IBS Research

The study found that 'adequate relief' was significantly correlated with improvements in pain severity, pain-free days, stool frequency and consistency, and overall quality of life. This suggests that 'adequate relief' can be a reliable and comprehensive endpoint for measuring the effectiveness of IBS treatments, providing a more patient-centered approach to evaluating treatment outcomes.

Finding the Right Path Through the Desert of IBS

This research provides a valuable framework for designing and interpreting clinical trials for IBS. The use of 'adequate relief' as an endpoint can help researchers gain a more nuanced understanding of the effectiveness of treatments and ultimately lead to better outcomes for patients struggling with IBS.

Dr.Camel's Conclusion

This research sheds light on the importance of using 'adequate relief' as an endpoint in clinical trials for irritable bowel syndrome (IBS). This patient-centered approach can provide a more comprehensive and meaningful assessment of treatment effectiveness, leading to improved outcomes for those suffering from this debilitating condition. It's like finding a new oasis in the desert of IBS research, offering a more accurate and patient-driven path towards finding effective treatments.

Date :
  1. Date Completed 1998-07-21
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

9602985

DOI: Digital Object Identifier

10.1177/030006059802600203

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・Effective treatment of irritable bowel syndrome
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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