Paper Details

  1. Home
  2. Paper Details

Topical metronidazole maintains remissions of rosacea.

Author: AlyR, BakerM O, BaylesC, ColemanE, CzernielewskiJ M, DahlM V, HerndonJ H, KatzH I, KruegerG G, MillikanL E, OdomR B, ParkerF, PatrignelliR, ReusserB, TuleyM R, WeidnerM, WolfJ E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that continued treatment with topical metronidazole gel alone maintains remission of moderate to severe rosacea in a majority of subjects previously treated with oral tetracycline and topical metronidazole gel.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Rosacea is a chronic skin disease that requires long-term therapy. Oral antibiotics and topical metronidazole successfully treat rosacea. Because long-term use of systemic antibiotics carries risks for systemic complications and adverse reactions, topical treatments are preferred. OBJEC...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1001/archderm.134.6.679

データ提供：米国国立医学図書館（NLM）

Rosacea: Maintaining Remission with Topical Metronidazole

Rosacea, a chronic skin condition, can cause redness, bumps, and inflammation, impacting the appearance and well-being of those affected. This study investigates the efficacy of topical metronidazole gel in maintaining remission of rosacea after initial treatment with oral antibiotics.

The researchers conducted a randomized, double-blind, placebo-controlled study to compare the effects of topical metronidazole gel with a placebo in patients who had achieved remission with oral tetracycline and topical metronidazole. They evaluated relapse rates and assessed changes in inflammatory lesions, erythema, and dryness over a period of six months.

The study found that topical metronidazole significantly prolonged the disease-free interval and minimized recurrence compared to placebo. Patients using metronidazole experienced fewer inflammatory lesions, less erythema, and less dryness, suggesting that continued use of topical metronidazole can effectively maintain remission of rosacea.

A Path to Long-Term Rosacea Management

This research provides evidence-based support for the use of topical metronidazole in managing rosacea. The findings suggest that this treatment can effectively maintain remission, reducing the need for long-term oral antibiotic therapy. It's like discovering a well in the desert, providing a sustainable source of relief for those suffering from this condition.

Navigating Rosacea Treatment with Confidence

This study provides a valuable tool for healthcare professionals and patients seeking effective long-term management of rosacea. It highlights the importance of considering topical metronidazole as a potential treatment option, offering a path to sustained remission.

Dr.Camel's Conclusion

This study offers valuable insights into the long-term management of rosacea, highlighting the efficacy of topical metronidazole in maintaining remission. It underscores the importance of individualized treatment approaches and the potential benefits of using topical therapies to minimize the need for systemic medications.

Date :
  1. Date Completed 1998-07-09
  2. Date Revised 2019-07-17
Further Info :

Pubmed ID

9645635

DOI: Digital Object Identifier

10.1001/archderm.134.6.679

Related Literature

Article Analysis
・Effective treatment of rosacea
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.