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Low-dose famotidine and effervescent cimetidine in healthy subjects: a placebo-controlled overnight pH study.

Author: CottrellJ, GrimleyC E, MannS G, NwokoloC U, RaskinS, ReillyT G, UsselmannB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compares the effects of famotidine 10 mg and cimetidine 200 mg on intragastric pH. Both medications increase intragastric pH, but cimetidine 200 mg in an effervescent formulation has a more rapid effect.
Paper Details　
Original Abstract of the Article :
Amongst the low-dose H2-receptor antagonists available for the self-medication of dyspepsia, both famotidine 10 mg and cimetidine 200 mg have been shown to raise intragastric pH, but there is a delay after ingestion before significant effects can be demonstrated. A new effervescent preparation of ci...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2036.1998.00323.x

データ提供：米国国立医学図書館（NLM）

Famotidine and Cimetidine: A Comparative Study of H2-Receptor Antagonists

This study compared the effects of low-dose famotidine and effervescent cimetidine on intragastric pH in healthy subjects. Both famotidine and cimetidine are H2-receptor antagonists used to treat dyspepsia. The study found that while both medications raised intragastric pH, the effervescent cimetidine preparation had a faster onset of action compared to famotidine. These findings suggest that the effervescent cimetidine formulation may be more effective in rapidly relieving symptoms of dyspepsia.

Effervescent Cimetidine: A Faster Route to Relief

This research suggests that the effervescent formulation of cimetidine may offer a quicker and more efficient way to relieve symptoms of dyspepsia compared to famotidine. The study's findings could lead to improvements in the management of dyspepsia by offering a more rapid onset of action and potentially enhancing patient satisfaction.

Choosing the Right Path to Relief: Navigating the Desert of Dyspepsia

This study provides a valuable comparison of two commonly used H2-receptor antagonists for dyspepsia, highlighting the potential benefits of the effervescent cimetidine formulation. The research encourages a thoughtful approach to managing dyspepsia, considering individual patient needs and preferences, and selecting the most appropriate medication for optimal relief. Just as a camel chooses the path best suited for its journey through the desert, patients and doctors should choose the treatment option that offers the most effective and rapid relief.

Dr.Camel's Conclusion

This study is like a camel exploring different oases, seeking the most effective way to quench the thirst of dyspepsia. It highlights the advantages of effervescent cimetidine in offering faster relief compared to famotidine. This research encourages a thoughtful approach to choosing the best path to relief, much like a camel carefully selecting its route through the desert.

Date :
  1. Date Completed 1998-09-16
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

9663728

DOI: Digital Object Identifier

10.1046/j.1365-2036.1998.00323.x

Related Literature

Article Analysis
・Effects of cimetidine・Effects of famotidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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