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Efficacy of different schedules in the management of chronic hepatitis C with interferon-alpha.

Author: Di FazioI, MalaguarneraM, PistoneG, RestucciaN, RestucciaS, TrovatoB A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

In a study of 255 people with chronic hepatitis C, different interferon (IFN) treatment schedules were compared. The highest remission rate (21.6%) was seen in those who received 3 million units (MU) of IFN three times a week for 12 months. Lower remission rates were seen in those who received 3 MU three times a week for 6 months (14.5%) and those who received 6 MU three times a week for 6 months (8%). Increasing the dosage or duration of treatment did not improve outcomes or patient adherence. Long-term effectiveness of treatment should be assessed based on both biochemical and virological factors.
Paper Details　
Original Abstract of the Article :
The best results in terms of clinical remission in chronic hepatitis C are achieved by interferon (IFN)-alpha treatment. We studied 255 patients affected by chronic hepatitis C infection (HCV) and divided into 3 groups. A different IFN-alpha therapeutic schedule was adopted in each group: A) 3 milli...See full text at original site
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引用元：
https://doi.org/10.3109/07853899808999406

データ提供：米国国立医学図書館（NLM）

Investigating the Efficacy of Different Schedules for Chronic Hepatitis C Treatment

Navigating the complexities of chronic hepatitis C is like exploring a vast, ever-shifting desert landscape. In this research, the authors focus on the effectiveness of interferon-alpha treatment in managing chronic hepatitis C infection. They studied 255 patients divided into three groups, each receiving a different interferon-alpha schedule. The researchers wanted to find the most effective schedule for achieving clinical remission in this challenging condition. This research offers valuable insights into the treatment of chronic hepatitis C, shedding light on the effectiveness of different interferon-alpha schedules.

Chronic Hepatitis C Treatment: Unveiling the Effectiveness of Different IFN-alpha Schedules

The study revealed that interferon-alpha treatment yielded varying degrees of success, depending on the schedule used. The most effective schedule was 3 million units (MU) three times per week for 12 months, achieving a sustained biohumoural and virological remission in 21.6% of patients. However, the adoption of more aggressive regimens didn't translate into improved response or patient compliance. This research emphasizes the importance of finding a balance between efficacy and tolerability in managing chronic hepatitis C, with longer treatment durations potentially yielding better outcomes.

Understanding the Implications for Hepatitis C Treatment

The results of this research highlight the importance of carefully tailoring treatment plans for patients with chronic hepatitis C. While interferon-alpha can be an effective treatment option, the optimal schedule requires careful consideration. It's important to weigh the potential benefits against the challenges of long-term therapy and to ensure that the chosen regimen maximizes patient compliance. Further research is needed to explore alternative treatment strategies and improve outcomes for individuals with chronic hepatitis C. This study serves as a valuable stepping stone in the ongoing quest to conquer this challenging condition.

Dr. Camel's Conclusion

This study is a testament to the tireless efforts of researchers in the pursuit of better treatments for chronic hepatitis C. While the desert of hepatitis C can be unforgiving, this research provides valuable insights into the efficacy of interferon-alpha. It's essential to remember that each patient is unique and requires personalized care. With continued research, we can hope to illuminate even brighter pathways towards a more effective and sustainable treatment for this debilitating condition.

Date :
  1. Date Completed 1998-09-01
  2. Date Revised 2019-09-21
Further Info :

Pubmed ID

9667801

DOI: Digital Object Identifier

10.3109/07853899808999406

Related Literature

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・Effective treatment of hepatitis c
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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