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[Combined therapy with cholestyramine and HMG-CoA reductase inhibitors in secondary prevention of coronary disease].

Author: AuriemoC, MartinezT L, NovazziJ P, PintoL do E

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that the association of cholestyramine to HMG-CoA reductase inhibitors, both in low doses, in patients with primary hypercholesterolemia and high coronary risk is a good therapeutic option that can reach benefits on the lipid profile similar to those obtained when these drugs are used in association or separately in higher doses.
Paper Details　
Original Abstract of the Article :
PURPOSE: To evaluate lipid profile changes associated with cholestyramine addition in hypercholesterolemic patients with established coronary heart disease under treatment with HMG-CoA reductase inhibitors that had not achieved the ideal value of LDL-cholesterol. METHODS: Twenty patients with coron...See full text at original site
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引用元：
https://doi.org/10.1590/s0066-782x1998000300003

データ提供：米国国立医学図書館（NLM）

Combined Therapy for Coronary Disease: Cholestyramine and HMG-CoA Reductase Inhibitors

The [prevention of coronary heart disease] is a major public health concern. This study explores the effectiveness of a combined therapy using [cholestyramine] and [HMG-CoA reductase inhibitors], commonly known as [statins], in patients with [established coronary heart disease] who have not achieved their [ideal LDL-cholesterol] levels.

A Powerful Combination for Lipid Control

The researchers found that adding [cholestyramine] to [statin] therapy resulted in a significant reduction in [total cholesterol and LDL-cholesterol] levels. This combined approach was successful in reducing [LDL-cholesterol] to [less than 100 mg/dL] in all participants. The study also noted a favorable increase in [HDL-cholesterol] levels.

A Personalized Approach to Heart Health

This study highlights the importance of [personalized treatment] in [cardiovascular disease]. While [statins] are a mainstay of [cholesterol management], some patients may require additional therapies to reach their [treatment goals]. It's like a camel choosing the best path through a diverse desert landscape – tailoring treatment to individual needs is key to achieving optimal health.

Dr. Camel's Conclusion

The combination of cholestyramine and statins effectively lowers cholesterol levels in patients with coronary heart disease. This finding underscores the need for a personalized approach to cardiovascular health. It's like discovering a hidden oasis in the desert of heart disease – a valuable combination therapy that can help achieve optimal cardiovascular health.

Date :
  1. Date Completed 1998-09-28
  2. Date Revised 2019-05-16
Further Info :

Pubmed ID

9674175

DOI: Digital Object Identifier

10.1590/s0066-782x1998000300003

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Languages

Portuguese

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