Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis. Glucocorticoid-Induced Osteoporosis Intervention Study Group.

Author: BrownJ P, CzachurM, DaifotisA G, DelmasP D, EmkeyR, GoemaereS, HawkinsF, LibermanU A, MaliceM P, SaagK G, SchnitzerT J, ThamsborgG

Paper Details 
Original Abstract of the Article :
BACKGROUND: Osteoporosis is a common complication of long-term glucocorticoid therapy for which there is no well-proved preventive or restorative treatment. METHODS: We carried out two 48-week, randomized, placebo-controlled studies of two doses of alendronate in 477 men and women, 17 to 83 years o...See full text at original site
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引用元:
https://doi.org/10.1056/NEJM199807303390502

データ提供:米国国立医学図書館(NLM)

Alendronate for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis

This study delves into the world of [osteoporosis], a condition that affects bone density and can lead to fractures. It's like a desert landscape where the once-solid dunes are eroding away. The study focuses on a common cause of osteoporosis – long-term glucocorticoid therapy, a treatment often used to manage various medical conditions. The researchers investigated the effectiveness of alendronate, a medication known for its bone-building properties, in preventing and treating glucocorticoid-induced osteoporosis. They found that alendronate was quite effective in increasing bone density in patients receiving glucocorticoids. It's like introducing a stabilizing force that strengthens the dunes and prevents further erosion.

Alendronate's Impact on Bone Density

The study demonstrated that alendronate significantly increased bone density in the lumbar spine and hip regions of patients receiving glucocorticoid therapy. It's like the desert wind carrying nourishing sand particles to strengthen and rebuild the eroding dunes. These findings highlight alendronate's potential as a valuable tool for managing glucocorticoid-induced osteoporosis.

Health Considerations and Applications

The study emphasizes the importance of understanding the potential risks associated with long-term glucocorticoid therapy. It's a reminder that these medications, while effective in treating various conditions, can have a detrimental effect on bone health. This study underscores the importance of preventive measures, including medication like alendronate, to protect against the bone-weakening effects of glucocorticoids. It's like introducing a protective barrier around the dunes to shield them from the harsh desert winds. Furthermore, the study highlights the need for personalized approaches to osteoporosis management, taking into account the specific needs of each individual.

Dr. Camel's Conclusion

This research offers a ray of hope for those facing the challenges of glucocorticoid-induced osteoporosis. Alendronate's effectiveness in increasing bone density presents a promising strategy for preventing and treating this condition. As we continue to explore the complexities of bone health, we gain a deeper appreciation for the intricate interplay of medication, lifestyle, and individual factors.

Date :
  1. Date Completed 1998-08-04
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

9682041

DOI: Digital Object Identifier

10.1056/NEJM199807303390502

Related Literature

SNS
PICO Info
in preparation
Languages

English

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