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Direct comparisons of adjuvant endocrine therapy, chemotherapy, and chemoendocrine therapy for operable breast cancer patients stratified by estrogen receptor and menopausal status.

Author: NomuraY, ShirouzuM, TakayamaT

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that hormone therapy alone was as effective as chemotherapy or a combination of hormone therapy and chemotherapy in preventing cancer recurrence and extending survival for premenopausal women with estrogen receptor-positive breast cancer. However, for postmenopausal women with the same type of cancer, combining hormone therapy with chemotherapy resulted in a significantly higher survival rate and a lower risk of cancer recurrence compared to hormone therapy or chemotherapy alone.
Paper Details　
Original Abstract of the Article :
Based on estrogen receptor (ER) and menopausal status, operable breast cancer (UICC stage I, II, III-a) patients were randomized for adjuvant endocrine therapy, chemotherapy, and chemoendocrine therapy, and the effects on the relapse-free survival (RFS) and overall survival (OS) were compared. Tamox...See full text at original site
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引用元：
https://doi.org/10.1023/a:1005901622642

データ提供：米国国立医学図書館（NLM）

Tailoring Treatment for Operable Breast Cancer: The Importance of Estrogen Receptor Status and Menopause

The fight against breast cancer is a journey that requires a personalized approach, tailored to the unique characteristics of each patient. This study explores the effectiveness of different adjuvant therapies for operable breast cancer, highlighting the crucial role of estrogen receptor (ER) status and menopausal status in determining the optimal treatment strategy. The authors conducted a randomized clinical trial comparing endocrine therapy, chemotherapy, and chemoendocrine therapy, providing valuable insights into the impact of these treatments on relapse-free survival and overall survival.

Precision Medicine in Action: ER Status and Menopause Dictate Optimal Breast Cancer Treatment

This research emphasizes the importance of precision medicine in breast cancer treatment, demonstrating the significant impact of ER status and menopausal status on treatment outcomes. The study reveals that for ER-positive, postmenopausal patients, the combination of tamoxifen and chemotherapy leads to improved relapse-free survival and overall survival compared to either treatment alone. This underscores the need for individualized treatment approaches that take into account the specific characteristics of each patient.

Informed Decision-Making: Understanding the Options and Making the Right Choice

This study provides valuable information for patients and their healthcare providers, emphasizing the importance of understanding the different treatment options available for breast cancer. The findings highlight the need for careful consideration of ER status and menopausal status when selecting the most appropriate treatment strategy. This research empowers individuals to participate in informed decision-making processes that ultimately lead to better outcomes.

Dr.Camel's Conclusion

This study emphasizes the crucial role of personalized medicine in breast cancer treatment. By carefully considering factors such as ER status and menopausal status, we can tailor therapy to the individual needs of each patient, maximizing the chances of successful treatment and improving long-term survival.

Date :
  1. Date Completed 1998-10-30
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

9694611

DOI: Digital Object Identifier

10.1023/a:1005901622642

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・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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