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Gabapentin and carbamazepine affect eye movements and posture control differently: a placebo-controlled investigation of acute CNS side effects in healthy volunteers.

Author: BüttnerU, FuhryL, NoachtarS, von MaydellB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effects of gabapentin (GBP), carbamazepine (CBZ), and placebo (PLA) on eye movements, posture, and finger force control in healthy volunteers. Both GBP and CBZ reduced saccade velocity, but CBZ significantly prolonged saccade duration. GBP increased body sway more than CBZ.
Paper Details　
Original Abstract of the Article :
This prospective study examined the effects of the new antiepileptic drug (AED) gabapentin (GBP) compared to the standard AED carbamazepine (CBZ) and placebo (PLA) on eye movements, posture and finger force control in 12 healthy volunteers who received single doses of 600 mg GBP and 400 mg CBZ in a ...See full text at original site
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引用元：
https://doi.org/10.1016/s0920-1211(98)00015-1

データ提供：米国国立医学図書館（NLM）

Gabapentin and Carbamazepine: Comparing Effects on Eye Movements and Posture

This study explores the effects of two antiepileptic drugs, gabapentin (GBP) and carbamazepine (CBZ), on eye movements and posture control in healthy volunteers. The study utilizes a double-blind, cross-over, randomized trial to compare the effects of GBP and CBZ to a placebo. The authors found that both GBP and CBZ had similar effects on saccade velocity. However, CBZ, but not GBP, prolonged the duration of saccades. Interestingly, GBP had a greater impact on posture control than CBZ, leading to increased body sway. The authors suggest that electro-oculography may be more appropriate for detecting CBZ-induced side effects, while posturography may be more sensitive for detecting GBP-related side effects.

Antiepileptic Drugs: Unraveling the Nuances of Side Effects

This study provides valuable insight into the distinct side effects of antiepileptic drugs, particularly regarding eye movements and posture. The findings highlight the importance of considering individual patient factors and the specific side effects of each drug when making treatment decisions. It is crucial to note that the study was conducted on healthy volunteers, and the results may not generalize to individuals with epilepsy or other conditions.

Navigating Antiepileptic Treatment: A Multifaceted Approach

Choosing the right antiepileptic drug for each individual is a complex process. It is important to consult with a qualified medical professional who can assess your individual needs and risks. If you are experiencing any side effects from antiepileptic medication, it is crucial to communicate with your doctor to ensure that your treatment plan is optimized for your specific needs.

Dr.Camel's Conclusion

This study reminds us that even though medications are prescribed to treat specific ailments, they can have varying effects on different aspects of the human body. This study specifically demonstrated the diverse effects of two antiepileptic drugs on eye movements and posture control. It emphasizes the importance of understanding the nuances of individual drug effects to ensure optimal patient care.

Date :
  1. Date Completed 1999-05-19
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

9696300

DOI: Digital Object Identifier

10.1016/s0920-1211(98)00015-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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