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Intravesical oxybutynin for neurogenic bladder dysfunction: less systemic side effects due to reduced first pass metabolism.

Author: AnderssonK E, BjörkH, BuyseG, CasaerP, VerpoortenC, WaldeckK

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study explored the differences in absorption and metabolism of oxybutynin after intravesical and oral administration. This may explain why intravesical oxybutynin is more effective and has fewer side effects.
Paper Details　
Original Abstract of the Article :
To unravel why intravesical oxybutynin is more effective and causes significantly fewer systemic side effects than oral oxybutynin in the treatment of neurogenic bladder dysfunction, we tested the hypothesis that the absorption and metabolism of oxybutynin are changed after intravesical instillation...See full text at original site
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引用元：
https://doi.org/10.1016/S0022-5347(01)62828-3

データ提供：米国国立医学図書館（NLM）

Intravesical Oxybutynin: A Targeted Approach for Neurogenic Bladder Dysfunction

Neurogenic bladder dysfunction, like a desert mirage, can lead to a sense of frustration and discomfort. This research investigates the potential of intravesical oxybutynin, a medication delivered directly to the bladder, to provide relief for those struggling with this condition. The authors explore the mechanism behind intravesical oxybutynin's effectiveness, seeking to explain why it often outperforms oral oxybutynin.

Understanding the Mechanism of Intravesical Oxybutynin

The study, like a meticulous desert cartographer, maps the journey of oxybutynin as it navigates the body. The researchers analyze the absorption and metabolism of this drug, seeking to understand how intravesical delivery leads to greater efficacy and fewer side effects compared to oral administration.

A New Path for Bladder Dysfunction Treatment

The study's findings suggest that intravesical oxybutynin, by bypassing the first-pass metabolism, may offer a more effective and less burdensome treatment option for neurogenic bladder dysfunction. This research provides valuable insights into the potential of targeted drug delivery strategies.

Dr.Camel's Conclusion

This research, like a desert oasis offering a refreshing solution, highlights the potential of targeted therapies for managing bladder dysfunction. The insights gained from this study could pave the way for more effective and less invasive treatment options for those struggling with this condition.
Date :
  1. Date Completed 1998-09-24
  2. Date Revised 2023-03-02
Further Info :

Pubmed ID

9720583

DOI: Digital Object Identifier

10.1016/S0022-5347(01)62828-3

Related Literature

Article Analysis
・Side Effects of oxybutynin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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