Hereditary angioedema: modification of clinical manifestations with androgens.

Author: CharacheP, DavisF B, DavisP J

Paper Details 
Original Abstract of the Article :
HAE is an autosomal dominant trait of decreased levels or function of circulating and tissue C'1 esterase inhibitor. The clinical illness is characterized by disabling episodes of peripheral, oropharyngeal and gut-wall edema. Long-term fluoxymesterone treatment of 5 affected males (393 patient-month...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/974251

データ提供:米国国立医学図書館(NLM)

Hereditary Angioedema: Androgens to the Rescue

Hereditary angioedema (HAE), a genetic disorder characterized by recurrent episodes of swelling, presents a significant challenge to patients' quality of life. This study explores the effectiveness of androgen therapy in managing HAE symptoms. The researchers investigated the impact of long-term treatment with fluoxymesterone in males and oxymetholone in females on the frequency of edema attacks. Their findings suggest a significant reduction in attack frequency without significant adverse effects, offering hope for HAE patients seeking symptom relief.

Androgen Therapy: A Potential Solution

This study demonstrates that androgen therapy can effectively reduce the frequency of edema attacks in patients with HAE. The researchers observed a significant decrease in attack frequency with both fluoxymesterone and oxymetholone, suggesting a potential benefit for a wide range of HAE patients. The study also highlights the need for further investigation into the long-term safety and efficacy of androgen therapy in this population.

Managing HAE: Hope for Relief

HAE can significantly impact daily life, and finding effective treatments is crucial for managing symptoms and improving quality of life. This study provides evidence for the potential benefit of androgen therapy in reducing edema attack frequency in HAE patients. It emphasizes the importance of personalized treatment approaches and continued research to optimize management strategies and improve patient outcomes.

Dr.Camel's Conclusion

Just like a camel adapting to the harsh desert environment, HAE patients require innovative solutions to manage their condition. This study demonstrates that androgen therapy might offer a promising strategy for reducing edema attack frequency, providing hope for a better quality of life for HAE patients.

Date :
  1. Date Completed 1976-12-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

974251

DOI: Digital Object Identifier

974251

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PICO Info
in preparation
Languages

English

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