Side Effects of fluoxymesterone: A Synthesis of Findings from 14 Studies

  1. Home
  2. Side Effects of fluoxymesterone
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of fluoxymesterone: A Synthesis of Findings from 14 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of fluoxymesterone: A Synthesis of Findings from 14 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Fluoxymesterone has been studied in several research projects, and its effects and side effects have been investigated. 8 reported that fluoxymesterone, when combined with tamoxifen, is more effective than tamoxifen alone in treating patients with advanced metastatic breast cancer, especially in terms of soft tissue response rates. 7 showed that fluoxymesterone, when combined with tamoxifen, improves response rates, remission duration, and time to treatment failure in breast cancer patients. 9 found that although fluoxymesterone combined with tamoxifen demonstrated higher response rates and improved time to progression compared to tamoxifen alone, it did not result in an improved survival duration. 12 reported that fluoxymesterone is effective in reducing the frequency of attacks in patients with hereditary angioedema. 11 demonstrated that fluoxymesterone can promote growth in boys with constitutional delay of growth and puberty or genetic short stature. 2 showed that fluoxymesterone increases platelet counts in patients with myelodysplastic syndromes with low platelet counts.

Reasons for Side Effects

Fluoxymesterone is a type of male hormone called an androgen. Androgens are involved in various physiological functions, including muscle and bone growth, male secondary sexual characteristics development, and sexual function maintenance. Fluoxymesterone exerts its effects by binding to androgen receptors and promoting androgen actions. However, it can also cause side effects related to androgens.

Common Side Effects

Masculinization

Fluoxymesterone may cause masculinization in women. Symptoms of masculinization include deepening of the voice, increased body hair, increased facial and body hair, menstrual irregularities, acne, and male-pattern baldness. If you experience any symptoms of masculinization after taking fluoxymesterone, consult your doctor. 8

Elevated Liver Enzymes

Fluoxymesterone can lead to elevated liver enzymes. Increased liver enzymes can indicate liver dysfunction. If you experience elevated liver enzymes after taking fluoxymesterone, consult your doctor. 8

Edema

Fluoxymesterone can cause edema. Edema occurs due to excessive fluid retention in the body. If you experience edema after taking fluoxymesterone, consult your doctor. 8

Gastrointestinal Symptoms

Fluoxymesterone can cause gastrointestinal symptoms. These symptoms include nausea, vomiting, loss of appetite, and diarrhea. If you experience gastrointestinal symptoms after taking fluoxymesterone, consult your doctor. 8

Blood Abnormalities

Fluoxymesterone may cause blood abnormalities. Blood abnormalities include a decrease in white blood cells and a decrease in platelets. If you experience blood abnormalities after taking fluoxymesterone, consult your doctor. 8

Side Effects Management

Masculinization

If you experience symptoms of masculinization after taking fluoxymesterone, consult your doctor. Your doctor may adjust the dosage of fluoxymesterone or consider other treatment options, depending on the severity of the symptoms. 8

Elevated Liver Enzymes

If you experience elevated liver enzymes after taking fluoxymesterone, consult your doctor. Your doctor will assess your liver function and may adjust the dosage of fluoxymesterone or consider other treatment options if necessary. 8

Edema

If you experience edema after taking fluoxymesterone, consult your doctor. Your doctor will determine the cause of the edema and may adjust the dosage of fluoxymesterone or consider other treatment options if necessary. 8

Gastrointestinal Symptoms

If you experience gastrointestinal symptoms after taking fluoxymesterone, consult your doctor. Your doctor may adjust the dosage of fluoxymesterone or consider other treatment options, depending on the severity of the symptoms. 8

Blood Abnormalities

If you experience blood abnormalities after taking fluoxymesterone, consult your doctor. Your doctor will monitor your blood abnormalities and may adjust the dosage of fluoxymesterone or consider other treatment options if necessary. 8

Research Comparison

Commonalities

Several studies have investigated the effectiveness and safety of fluoxymesterone. These studies suggest that fluoxymesterone is an effective treatment for various conditions. Additionally, research reports indicate that fluoxymesterone's side effects are generally mild.

Differences

While various studies have explored the effectiveness and side effects of fluoxymesterone, the results show some variability due to differences in study populations, dosages, and treatment durations. Therefore, more research is needed to draw definite conclusions about fluoxymesterone's side effects.

Precautions for Real-Life Application

Take fluoxymesterone only under your doctor's supervision. Do not take it without consulting your doctor or adjust the dosage on your own. If you experience any changes in your health or side effects while taking fluoxymesterone, consult your doctor immediately. 8

Current Research Limitations

Research on fluoxymesterone's side effects is not yet exhaustive. Specifically, data on long-term side effects from prolonged use is still limited. Moreover, it is known that fluoxymesterone's side effects vary significantly among individuals, making accurate prediction difficult.

Future Research Directions

To gain a deeper understanding of fluoxymesterone's side effects, further research is crucial. Specifically, unraveling the mechanisms behind long-term side effects and individual variations in side effect occurrence is essential. Additionally, developing new treatments to mitigate fluoxymesterone's side effects is a promising avenue for exploration.

Conclusion

Fluoxymesterone is an effective treatment for various conditions, but it can cause side effects such as masculinization, elevated liver enzymes, edema, gastrointestinal symptoms, and blood abnormalities. If you are considering taking fluoxymesterone, consult your doctor and choose a treatment plan that suits your condition. 8

Literature analysis of 14 papers
Positive Content
14
Neutral Content
0
Negative Content
0
Article Type
4
1
0
0
14
2.

Androgen therapy in myelodysplastic syndromes with thrombocytopenia: a report on 20 cases.

Author: WattelE, CambierN, CaulierM T, SautièreD, BautersF, FenauxP

Increased platelet counts
Reduced bleeding symptoms
Moderate side effects

Androgen therapy was found to be useful in treating severe thrombocytopenia in patients with low-risk myelodysplastic syndromes (MDS), with a moderate side-effect profile and a response rate of 55%.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Effect of conventional dose growth hormone therapy for two years on height velocity and height prognosis in girls with Turner syndrome.

Author: LenkoH L, HakulinenA, KäärM L, MäenpääJ, MäkeläA L, SipiläI

Improved height prognosis
Increased height velocity
No side effects

This study investigated the use of growth hormone (GH) therapy in girls with Turner syndrome, a genetic disorder that affects growth. The study found that GH therapy significantly increased height velocity in these girls, although the long-term effects on final height are unknown. GH therapy was well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Effect of long-acting gonadotropin-releasing hormone analog (leuprolide) therapy on prostatic size and symptoms in 15 men with benign prostatic hypertrophy.

Author: GabriloveJ L, LevineA C, KirschenbaumA, DrollerM

Improves urinary flow
Treats benign prostatic hyperplasia
Decreased potency
Flushing

Leuprolide, a GnRH analog, was effective in shrinking prostates and improving urinary symptoms in 15 patients with benign prostatic hypertrophy. Prostate size and symptoms returned to baseline after stopping treatment or when combined with androgens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Evaluation of tamoxifen doses with and without fluoxymesterone in advanced breast cancer.

Author: TormeyD C, LippmanM E, EdwardsB K, CassidyJ G

Breast cancer remission
Improved survival
Longer remission duration
Androgen side effects

Tamoxifen and fluoxymesterone were compared in 108 patients with metastatic breast carcinoma. The combination regimen was more effective than tamoxifen alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

Evaluation of tamoxifen dose in advanced breast cancer: a progress report.

Author: TormeyD C, SimonR M, LippmanM E, BullJ M, MyersC E

Breast cancer treatment
Improved response rate
Edema
Hematologic suppression
Hepatic enzyme elevations
Masculinization
Nausea

Tamoxifen (Tam) and Tam plus fluoxymesterone (Flu) were compared in patients with progressive, metastatic breast carcinoma. The combination of Tam and Flu had a higher response rate overall (45% vs 28%) and when only the patients' soft tissue sites were analyzed (54% vs 9%).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Randomized clinical trial of tamoxifen alone or combined with fluoxymesterone in postmenopausal women with metastatic breast cancer.

Author: IngleJ N, TwitoD I, SchaidD J, CullinanS A, KrookJ E, MailliardJ A, MarschkeR F, LongH J, GerstnerJ G, WindschitlH E

Breast cancer treatment
Androgenic side effects

Combination hormonal therapy with tamoxifen (TAM) and fluoxymesterone (FLU) was more effective than TAM alone in treating postmenopausal women with metastatic breast cancer. TAM plus FLU resulted in a 53% response rate compared to 42% for TAM alone (P=.05). However, there was no survival advantage and the treatment group experienced more androgenic side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Hereditary angioedema: modification of clinical manifestations with androgens.

Author: DavisP J, DavisF B, CharacheP

Decreased edema frequency

Fluoxymesterone and oxymetholone were found to be effective in decreasing the frequency of attacks of edema in patients with hereditary angioedema (HAE).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Antiestrogen treatment of breast cancer: an overview.

Author: PearsonO H, ManniA, ArafahB M

Effective after prior endocrine therapy
Effective for breast cancer
Nontoxic

Tamoxifen, a nonsteroidal antiestrogen, was found to be an effective and nontoxic endocrine therapy for women with Stage IV and II estrogen receptor-positive breast cancer. In a series of 113 patients with Stage IV breast cancer, tamoxifen induced objective remissions in 50%, lasting an average period of 21 months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Evaluation of tamoxifen dose in advanced breast cancer: a progress report.

Author: TormeyD C, SimonR M, LippmanM E, BullJ M, MyersC E

Breast cancer treatment
Improved response rate
Edema
Hematologic suppression
Hepatic enzyme elevations
Masculinization
Nausea

Tamoxifen (Tam) and Tam plus fluoxymesterone (Flu) were compared in patients with progressive, metastatic breast carcinoma. The combination of Tam and Flu had a higher response rate overall (45% vs 28%) and when only the patients' soft tissue sites were analyzed (54% vs 9%).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.