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Biologic activity of tamoxifen at low doses in healthy women.

Author: BarrecaA, BettegaD, BonanniB, BoyleP, CostaA, DecensiA, FaranteG, GandiniS, Guerrieri-GonzagaA, JohanssonH, RobertsonC, SalinaroF, SandriM T, TessadrelliA, TravagliniR, VeronesiU

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of tamoxifen at doses lower than those currently used on biomarkers related to breast cancer prevention and potential adverse effects, such as endometrial cancer and venous thromboembolic events.
Paper Details　
Original Abstract of the Article :
Results of a clinical trial recently completed in the United States indicate that administration of tamoxifen (20 mg/day) to women at risk can reduce breast cancer incidence by approximately 50% but is associated with an increased risk of developing endometrial cancer and venous thromboembolic event...See full text at original site
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引用元：
https://doi.org/10.1093/jnci/90.19.1461

データ提供：米国国立医学図書館（NLM）

Biologic Activity of Tamoxifen at Low Doses in Healthy Women

This research, like a careful traveler assessing the terrain before embarking on a journey, investigates the effects of tamoxifen, a drug used to treat breast cancer, at lower doses than those currently used. The study explores the potential for lower doses to reduce the risk of breast cancer while minimizing side effects. The researchers examine the impact of tamoxifen on various biomarkers in healthy women, seeking to identify optimal dosing strategies for this drug.

Finding the Right Path: Exploring Low-Dose Tamoxifen

This research, like a desert explorer seeking the most efficient route, explores the effects of tamoxifen, a breast cancer treatment, at lower doses. The study investigates the potential for lower doses to minimize side effects while maintaining therapeutic efficacy, providing valuable insights into the optimal dosing strategies for this drug. This research, like a well-stocked caravan, aims to ensure the safe and effective journey of breast cancer treatment for patients.

Balancing Benefits and Risks: Personalized Dosing for Tamoxifen

This research, like a wise camel navigating a desert, highlights the importance of considering both the benefits and risks associated with tamoxifen, a drug used to treat breast cancer. The study explores the potential for lower doses to reduce the risk of breast cancer while minimizing side effects, advocating for a personalized approach to dosing this medication. This research serves as a reminder that achieving optimal therapeutic outcomes often involves finding the right balance between benefits and risks.

Dr. Camel's Conclusion

This research, like a camel navigating the vast desert of medical knowledge, delves into the effects of tamoxifen, a breast cancer treatment, at lower doses. The study's findings offer valuable insights into the potential for lower doses to minimize side effects while maintaining therapeutic efficacy. This research serves as a reminder that finding the right dosage for each patient is crucial for ensuring the safety and effectiveness of medication.
Date :
  1. Date Completed 1998-10-28
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

9776411

DOI: Digital Object Identifier

10.1093/jnci/90.19.1461

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Article Analysis
・Effects of tamoxifen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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