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[Preparation and utility of glibenclamide suppository for hospital use].

Author: IwataM, MachidaY, NagaiT, ShirotakeS, TakahashiY, TakayamaK

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the usefulness of glibenclamide (GC) suppositories in treating non-insulin dependent diabetes mellitus. The suppositories were found to release GC continuously for 6 hours and significantly lower blood glucose levels compared to control, suggesting their potential as an alternative treatment option.
Paper Details　
Original Abstract of the Article :
Glibenclamide (GC) is widely used as an oral hypoglycemic drug in the treatment of non-insulin dependent diabetes mellitus (NIDDM). Since GC is usually taken for a long period, side effects and noncompliance are among the problems. In order to solve those problems, we prepared GC suppositories and e...See full text at original site
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引用元：
https://doi.org/10.1248/yakushi1947.118.9_401

データ提供：米国国立医学図書館（NLM）

Glibenclamide Suppositories: A New Approach to Diabetes Management

Diabetes is a chronic condition that requires lifelong management. This study investigates the potential of using glibenclamide (GC) suppositories, which are inserted rectally, to treat non-insulin-dependent diabetes mellitus (NIDDM). This approach aims to improve treatment adherence and reduce side effects associated with oral medication.

GC Suppositories: A Promising Delivery Method

The researchers found that GC suppositories effectively release the drug into the bloodstream, leading to a reduction in blood glucose levels in rabbits. The suppositories were well-tolerated, and the researchers observed no significant side effects. These findings suggest that GC suppositories could be a valuable alternative to oral medication for managing NIDDM.

Exploring New Options for Diabetes Treatment

This research points to the ongoing exploration of new and innovative ways to manage chronic conditions like diabetes. The development of GC suppositories could potentially offer a more convenient and effective treatment option for some patients. It's important to discuss treatment options with your doctor to determine the best approach for your individual needs.

Dr.Camel's Conclusion

Imagine finding a hidden oasis in the vast desert. This study suggests that GC suppositories could be a refreshing alternative to oral medication for people with diabetes, offering a potentially more convenient and effective way to manage their condition.

Date :
  1. Date Completed 1999-01-22
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

9779000

DOI: Digital Object Identifier

10.1248/yakushi1947.118.9_401

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in preparation
Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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