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Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men.

Author: Barger-LuxM J, ChenT C, DowellS, HeaneyR P, HolickM F

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

In a study of 116 healthy men, different doses of vitamin D3, 25(OH)D3, and 1,25(OH)2D3 were given for short periods of time. Vitamin D3 increased blood levels of vitamin D and 25(OH)D, while 25(OH)D3 only increased blood levels of 25(OH)D. 1,25(OH)2D3 increased blood levels of 1,25(OH)2D. These findings suggest that taking 400 IU of vitamin D3 daily for 8 weeks would increase blood vitamin D levels by 9 nmol/l and 25(OH)D levels by 11 nmol/l. Taking 20 micrograms of 25(OH)D3 daily for 4 weeks would increase blood 25(OH)D levels by 94 nmol/l. Taking 0.5 micrograms of 1,25(OH)2D3 daily for 2 weeks would increase blood 1,25(OH)2D levels by 17 pmol/l.
Paper Details　
Original Abstract of the Article :
We determined the quantitative relationships between graded oral dosing with vitamin D3, 25(OH)D3, and 1,25(OH)2D3 for short treatment periods and changes in circulating levels of these substances. The subjects were 116 healthy men (mean age, 28 +/- 4 years, with usual milk consumption of < or = 0.4...See full text at original site
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引用元：
https://doi.org/10.1007/s001980050058

データ提供：米国国立医学図書館（NLM）

Vitamin D: Exploring the Desert of Optimal Dosing

Vitamin D, an essential nutrient often called the 'sunshine vitamin,' plays a vital role in maintaining bone health and overall well-being. This research explores the quantitative relationships between different oral doses of vitamin D3, 25(OH)D3, and 1,25(OH)2D3 and their corresponding changes in circulating levels of these substances. The authors conducted a study involving 116 healthy men, administering graded doses of these vitamin D forms and measuring the resulting serum levels. Their findings reveal a dose-dependent increase in circulating levels of vitamin D3 and 25(OH)D3, providing valuable data for understanding the pharmacokinetics of these compounds. This information can inform the development of individualized dosing strategies to ensure optimal vitamin D levels.

Navigating the Desert of Vitamin D Dosing: Finding the Right Balance

The study provides valuable insights into the pharmacokinetics of vitamin D, helping us to understand how different doses of vitamin D3, 25(OH)D3, and 1,25(OH)2D3 affect circulating levels. This knowledge can guide clinicians in developing personalized dosing strategies to achieve optimal vitamin D levels and support bone health and overall well-being.

A New Oasis in the Desert of Vitamin D: Understanding Dosing Strategies

The research offers a valuable roadmap for navigating the desert of vitamin D dosing, providing a more precise understanding of how different doses affect circulating levels. This knowledge empowers clinicians to develop personalized strategies for optimizing vitamin D levels and promoting overall health.

Dr. Camel's Conclusion

The desert of vitamin D can be confusing, with a vast array of forms and doses available. This study provides a valuable oasis of information, helping us to understand the relationship between different doses and circulating levels. By carefully navigating this landscape, we can ensure that we are getting the right amount of vitamin D to support our health and well-being.

Date :
  1. Date Completed 1998-11-17
  2. Date Revised 2022-03-10
Further Info :

Pubmed ID

9797906

DOI: Digital Object Identifier

10.1007/s001980050058

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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