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Phenylacetate in chemoprevention: in vitro and in vivo suppression of 5-aza-2'-deoxycytidine-induced carcinogenesis.

Author: PrasannaP, SamidD, ShackS, WilsonV L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Phenylacetate was found to prevent carcinogenesis by the chemotherapeutic hypomethylating drug 5-aza-2'-deoxycytidine (5AzadC) in vitro and in mice. Phenylacetate and its precursor, phenylbutyrate, may represent a new class of chemopreventive agents.
Paper Details　
Original Abstract of the Article :
Differentiation inducers selected for their low cytotoxic and genotoxic potential could be of major value in chemoprevention and maintenance therapy. We focus here on phenylacetate, a naturally occurring plasma component recently shown to affect the growth and differentiation of established neoplasm...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9816056

データ提供：米国国立医学図書館（NLM）

The Desert of Cancer: Seeking Strategies for Prevention

Cancer is like a dangerous sandstorm in the desert of our bodies. It can cause widespread damage and threaten our health. This research focuses on a new strategy for cancer prevention, using a compound called phenylacetate.

Testing a New Approach to Prevention

The researchers investigated the ability of phenylacetate to prevent cancer caused by a specific drug, 5-aza-2'-deoxycytidine (5AzadC). It's like testing a new type of camel, designed to withstand the harsh desert conditions and prevent sandstorms from forming.

A Promise of Protection

The results suggest that phenylacetate can effectively prevent cancer induced by 5AzadC, both in laboratory studies and in animal models. It's like finding a new oasis in the desert, offering a safe haven from the danger of cancer.

Dr. Camel's Conclusion

This research is a promising step towards developing new strategies for cancer prevention. It highlights the importance of exploring natural compounds for their potential therapeutic benefits, just as a skilled camel driver uses their knowledge of the desert to find hidden oases. As we continue to research and explore, we can hope to find more ways to combat cancer and protect our health from this dangerous sandstorm.
Date :
  1. Date Completed 1999-02-18
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

9816056

DOI: Digital Object Identifier

9816056

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English

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