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Vascular effects of estrogen and cholesterol-lowering therapies in hypercholesterolemic postmenopausal women.

Author: BuiM N, CannonR O, CardilloC, CsakoG, HathawayL, KohK K, PanzaJ A, WaclawiwM A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Estrogen therapy appears to have unique properties that may benefit the vasculature of hypercholesterolemic postmenopausal women, even if they are already on cholesterol-lowering therapy. In a randomized trial of 28 women, estrogen therapy and statin therapy had differing effects on lipoprotein levels, but similarly improved endothelium-dependent vasodilator responsiveness. However, only therapies including estrogen improved markers of fibrinolysis and vascular inflammation.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Lipoproteins affect endothelium-dependent vasomotor responsiveness. Because lipoprotein effects of estrogen and cholesterol-lowering therapies differ, we studied the vascular responses to these therapies in hypercholesterolemic postmenopausal women. METHODS AND RESULTS: We randomly assi...See full text at original site
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引用元：
https://doi.org/10.1161/01.cir.99.3.354

データ提供：米国国立医学図書館（NLM）

Estrogen and Cholesterol-Lowering Therapies: A Vascular Showdown

The health of our blood vessels is paramount to our overall well-being. This research investigates the effects of estrogen and cholesterol-lowering therapies on vascular function in hypercholesterolemic postmenopausal women. The researchers conducted a randomized controlled trial, comparing the effects of conjugated equine estrogen (CE), simvastatin, and a combination of both on vascular responses. They measured various markers of vascular health, including lipoprotein levels, flow-mediated dilation, and markers of inflammation and fibrinolysis. The study revealed that both estrogen and simvastatin improve vascular function in postmenopausal women, but estrogen therapy has unique benefits in reducing markers of inflammation and improving fibrinolysis. This highlights the potential for estrogen to have a more comprehensive impact on vascular health beyond simply lowering cholesterol levels. This study provides valuable insights into the potential benefits of estrogen therapy for postmenopausal women with cardiovascular risk factors.

Estrogen: A Champion for Vascular Health?

The study suggests that estrogen therapy may have unique benefits for vascular health in postmenopausal women, potentially providing additional advantages beyond cholesterol reduction. This information is valuable for physicians when considering treatment options for postmenopausal women with cardiovascular risk factors.

Maintaining Vascular Health: A Holistic Approach

This research underscores the importance of considering a holistic approach to maintaining vascular health in postmenopausal women. While cholesterol-lowering therapies are crucial, the study suggests that estrogen therapy may offer additional benefits in improving vascular function and reducing inflammation. This study encourages a broader understanding of the factors influencing vascular health and encourages a personalized approach to treatment.

Dr.Camel's Conclusion

Just like a wise camel navigating the harsh desert environment, this study explores the complex landscape of vascular health in postmenopausal women. It sheds light on the unique benefits of estrogen therapy, highlighting its potential role in maintaining vascular health beyond cholesterol reduction.

Date :
  1. Date Completed 1999-02-11
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

9918521

DOI: Digital Object Identifier

10.1161/01.cir.99.3.354

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Languages

English

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