Paper Details

  1. Home
  2. Paper Details

Evaluation of allergenic potential of low-molecular compounds by mouse popliteal lymph node assay.

Author: AidaT, IshikawaN, KimuraT, ShinkaiK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Mouse local lymph node assay (PLNA) was shown to correlate with guinea pig sensitization assays for allergenicity prediction of drugs. Ten drugs known to induce allergic reactions in humans caused increased PLN cellularity indices in the mouse PLNA.
Paper Details　
Original Abstract of the Article :
In the present study, the correlation between mouse PLNA results and those obtained from GP-PCA and from GP-ASA reactions for sodium 2,4,6-trinitrobenzenesulfonate dihydrate (TNBS), penicillin G and cephalothin was investigated. Next, various drugs were tested using the mouse PLNA to study whether P...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.2131/jts.23.5_425

データ提供：米国国立医学図書館（NLM）

Mouse Popliteal Lymph Node Assay: A New Tool for Assessing Allergenic Potential

As a researcher with a keen interest in the safety and efficacy of medications, I'm always on the lookout for new tools to assess the potential risks associated with drug exposure. This study introduces a novel approach for evaluating the allergenic potential of low-molecular compounds using a mouse popliteal lymph node assay (PLNA).

The authors meticulously investigate the correlation between PLNA results and other established methods for assessing allergenicity, such as guinea pig sensitization and challenge tests. They apply the PLNA to a range of drugs known to induce allergic reactions in humans, demonstrating its ability to detect allergenic potential.

The study reveals that PLNA results correlate well with allergenicity data obtained from guinea pig models, suggesting its potential as a valuable tool for assessing allergenic potential in early drug development stages. It offers a promising alternative to traditional animal models, paving the way for more efficient and ethical assessment of drug safety.

Mouse Popliteal Lymph Node Assay: A Promising New Tool for Assessing Allergenic Potential

This study introduces a novel and potentially valuable tool for assessing allergenic potential in early drug development stages. The PLNA offers a promising alternative to traditional animal models, paving the way for more efficient and ethical assessment of drug safety.

The Importance of Early Allergenicity Assessment

This study underscores the importance of early allergenicity assessment in drug development. The PLNA offers a promising new tool for evaluating allergenic potential, contributing to the development of safer and more effective medications.

Dr. Camel's Conclusion

This study introduces a novel and potentially valuable tool for assessing allergenic potential in early drug development stages. The PLNA offers a promising alternative to traditional animal models, paving the way for more efficient and ethical assessment of drug safety.

Date :
  1. Date Completed 1999-04-14
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

9922946

DOI: Digital Object Identifier

10.2131/jts.23.5_425

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.