Side Effects of penicillin g (potassium sodium) injection: A Synthesis of Findings from 4 Studies

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Original Abstract of the Article

Main Research Findings

Several studies have shown that penicillin G injections are effective in treating bacterial infections such as pneumonia. 2 reports that high doses of penicillin G administered intramuscularly are effective in treating pneumonia. Additionally, 4 found that cefazolin and penicillin G procaine are equally effective in treating pneumococcal pneumonia. These studies suggest that penicillin G is an effective antibiotic for the treatment of bacterial infections.

Reasons for side effects

Penicillin G injections can trigger a response from the body's immune system, potentially leading to allergic reactions and other side effects. 1 demonstrates in a mouse experiment that penicillin G has the potential to cause allergic reactions.

Common side effects

Allergic reactions

Penicillin G injections can cause allergic reactions. 3 reports patients who experienced allergic reactions during the administration of penicillin G injections. Allergic reactions can manifest in various symptoms, including rashes, hives, difficulty breathing, and anaphylactic shock.

Pain

You may experience pain at the injection site of the penicillin G injection. 2 reports patients experiencing significant pain at the injection site after receiving penicillin G injections intramuscularly.

Other side effects

Penicillin G injections can cause side effects such as nausea, vomiting, diarrhea, dizziness, and fever. 2 observed side effects such as asthenia, dizziness, and chest pain in a portion of elderly patients who received penicillin G injections.

Side effects countermeasures

Countermeasures for allergic reactions

It is crucial to inform your doctor about any history of allergies before receiving penicillin G injections. If you experience an allergic reaction, contact your doctor immediately.

Countermeasures for pain

If you experience pain at the injection site of the penicillin G injection, consult your doctor.

Comparison between studies

Common points among studies

Multiple studies have indicated that penicillin G is effective in treating bacterial infections. Additionally, a common finding is that penicillin G injections can cause allergic reactions and other side effects.

Differences between studies

The administration methods, dosages, types, and frequencies of side effects for penicillin G injections vary among studies. 3 reports side effects when penicillin G injections were administered at a dosage of 2g once a day for 4 weeks. 2 reports side effects when penicillin G injections were administered at a dosage of 12 million units every 4-6 hours. 4 reports side effects when penicillin G procaine was administered at a dosage of 600,000 units twice a day. These research findings highlight that the administration method and dosage of penicillin G injections can influence the types and frequency of side effects.

Precautions for real-life applications

Penicillin G injections are an effective antibiotic for the treatment of bacterial infections. However, penicillin G injections can cause side effects such as allergic reactions. Therefore, when using penicillin G injections, it is crucial to follow your doctor's instructions carefully and be fully aware of the potential side effects.

Limitations of current research

While there have been numerous studies evaluating the safety and efficacy of penicillin G injections, not all side effects have been fully elucidated. Additionally, long-term effects of penicillin G injections have not been extensively studied yet.

Future research directions

More research is needed to further clarify the safety and efficacy of penicillin G injections. In particular, detailed studies on the long-term effects of penicillin G injections are essential.

Conclusion

Penicillin G injections are an effective antibiotic for the treatment of bacterial infections. However, they can cause side effects such as allergic reactions. When using penicillin G injections, adhere strictly to your doctor's instructions and be fully aware of the potential side effects.

Literature analysis of 4 papers
Positive Content
4
Neutral Content
0
Negative Content
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Article Type
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4
2.

[Effectiveness of the intramuscular administration of high doses of penicillin in treating pneumonia].

Author: SmirnovG A, FattakhovaR M, PetrashevskaiaV A

Effective pneumonia treatment
High penicillin efficiency
Asthenia
Dizziness
Heart pain
Painful injection

High doses of benzylpenicillin were effective in treating pneumonia. Elevated doses of benzylpenicillin proved to be effective in 78% of cases, with the effect being observed in all cases of acute pneumonia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

3.

Treatment of streptococcal endocarditis with a single daily dose of ceftriaxone sodium for 4 weeks. Efficacy and outpatient treatment feasibility.

Author: FrancioliP, EtienneJ, HoignéR, ThysJ P, GerberA

Easy to administer
Effective against streptococcal endocarditis
No relapse
Well tolerated
Drug allergy
Neutropenia

Ceftriaxone sodium was found to be effective and safe in the treatment of streptococcal endocarditis. In a study of 59 patients, no patients experienced a relapse after 4 months to 5 years of follow-up. Treatment was uneventful in 71% of patients, and the most common side effect was drug allergy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Cefazolin vs penicillin. Treatment of uncomplicated pneumococcal pneumonia.

Author: JenkinsonS G, GeorgeR B, LightR W, GirardW M

Pneumococcal pneumonia treatment

Cefazolin sodium was as effective as penicillin G procaine in treating pneumococcal pneumonia. Both treatments were safe and well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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