Effects of amikacin oral inhalation: A Synthesis of Findings from 11 Studies

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Original Abstract of the Article

Key Research Findings

Amiodarone, a medication used to control irregular heartbeats, has been studied extensively. 7 explores the potential of using the QT/RR relationship as a predictor of ineffective amiodarone treatment in patients recovering from a heart attack. 8 compares the effectiveness and side effects of amiodarone and sotalol, another heart rhythm medication, in patients with atrial fibrillation (a type of irregular heartbeat). 11 examines the use of amiodarone and lidocaine during cardiac arrest, finding that these medications may increase the likelihood of hospital admission compared to a placebo. 9 investigates dronedarone, a newer drug related to amiodarone, as a potential alternative with fewer side effects. 3 reviews research on amiodarone in patients with chronic heart failure, finding that it may reduce mortality rates but also significantly increase the risk of side effects. 4 explores the use of intravenous amiodarone for treating severe, life-threatening irregular heartbeats and its effectiveness in improving survival rates after out-of-hospital cardiac arrest. 10 highlights the potential for amiodarone to cause eye problems. 1 explores the relationship between amiodarone blood levels and its effects on blood pressure and heart function. 5 and 6 delve into the potential of newer formulations of amiodarone and its use in combination with other medications. 2 compares amiodarone and lidocaine in patients with a heart attack, finding both medications to be effective with minimal side effects.

Benefits and Risks

Benefit Summary

Amiodarone has demonstrated effectiveness in controlling various heart rhythm problems. 3 suggests a potential benefit in reducing mortality rates in patients with chronic heart failure. 4 highlights its effectiveness in acutely treating life-threatening irregular heartbeats and improving survival rates after out-of-hospital cardiac arrest. 5 suggests a new formulation of amiodarone may offer reduced side effects while remaining effective in controlling heart rhythm problems. However, it's essential to remember that amiodarone's effectiveness may vary between individuals, as 7 illustrates.

Risk Summary

Amiodarone, as documented in 7 and 3 , can cause serious side effects, including thyroid problems, lung fibrosis, and liver damage. 10 identifies potential eye problems as a side effect. 1 indicates that higher blood levels of amiodarone are associated with an increased risk of adverse effects. It's crucial to exercise caution and closely monitor patients while using amiodarone to minimize the risks associated with its use.

Comparison of Studies

Similarities between Studies

Numerous studies consistently highlight both the potential benefits and risks associated with amiodarone. A common understanding exists that while amiodarone can effectively manage various heart rhythm disorders, it also carries a significant risk of serious side effects.

Differences between Studies

Research findings concerning the efficacy and adverse effects of amiodarone may differ due to variations in patient populations, study designs, and evaluation methodologies. For instance, 7 focuses on predicting ineffective amiodarone treatment in patients recovering from heart attacks. Conversely, 8 directly compares amiodarone and sotalol, examining their effectiveness and side effect profiles. These distinctions in research objectives and methodologies can lead to differing conclusions regarding amiodarone's effects.

Consistency and Discrepancies in Results

Research findings on amiodarone exhibit both consistency and discrepancies. It's consistently established that amiodarone is effective in managing various heart rhythm irregularities while carrying a notable risk of serious side effects. However, specific details regarding efficacy and side effect profiles can vary across studies due to differences in patient demographics, study designs, and assessment methods. Therefore, comprehensive assessment of amiodarone's therapeutic benefits and risks necessitates consideration of multiple research findings.

Practical Applications and Cautions

Amiodarone is a medication used to control irregular heartbeats, but it carries significant risks of side effects. Patients should strictly adhere to their physician's instructions when taking amiodarone and be vigilant for any signs of potential adverse effects. Furthermore, as amiodarone can interact with other medications, it's crucial to discuss its use with a physician before taking any other medications. Close collaboration with a healthcare provider is vital for safe and effective amiodarone use.

Limitations of Current Research

Research on amiodarone is still ongoing, and several limitations exist. Further research is needed to understand long-term safety, predict individual patient responses to amiodarone, and elucidate its interactions with other medications. Optimal dosage regimens for amiodarone also require further investigation.

Future Research Directions

Future research should focus on predicting individual patient responses to amiodarone, evaluating long-term safety, and investigating interactions with other medications. Optimizing dosage regimens for amiodarone is also crucial. Additionally, research aimed at developing new medications or treatment strategies to mitigate amiodarone's side effects holds significant promise.

Conclusion

Amiodarone effectively controls irregular heartbeats but carries the risk of serious side effects. Adhering to physician instructions, monitoring for potential side effects, and consulting with a physician before taking other medications are crucial for safe amiodarone use. Research on amiodarone continues, and future studies should focus on predicting individual responses, long-term safety, interactions with other medications, and optimal dosage regimens. Development of strategies to minimize amiodarone's side effects is essential for enhancing patient outcomes.

Literature analysis of 11 papers
Positive Content
8
Neutral Content
0
Negative Content
3
Article Type
8
3
2
1
11
1.

Amiodarone and N-desethylamiodarone concentrations in plasma, red blood cells, and myocardium after a single oral dose: relation to hemodynamic effects in surgical patients.

Author: EscoubetB, JaillonP, BergerY, ComminP, MenaschéP, PiwnicaA, EchterE

Impaired hemodynamics

Oral amiodarone, an antiarrhythmic drug, was found to impair hemodynamics in surgical patients. The drug decreased cardiac index and heart rate, and increased capillary wedge pressure. Measuring amiodarone plasma concentration was the easiest method for monitoring the drug, but further investigation is needed to determine the clinical utility of drug monitoring during chronic administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Intravenous administration of lidocaine and amiodarone in patients with acute myocardial infarction].

Author: CapucciA, MelandriG, MantovaniB, MarestaA, MagnaniB

Reduced ventricular arrhythmias
Blood pressure decrease
QTc prolongation
Ventricular fibrillation

Amiodarone was as effective as lidocaine in treating life-threatening ventricular arrhythmias in patients with acute myocardial infarction. Amiodarone prolonged the QTc interval and slightly decreased systolic blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

3.

Overview and meta-analysis of randomised trials of amiodarone in chronic heart failure.

Author: PiepoliM, VillaniG Q, PonikowskiP, WrightA, FlatherM D, CoatsA J

Reduction in deaths
Increased side effects

This article reviews the use of amiodarone in patients with heart failure. While meta-analysis suggests a significant reduction in deaths, it also highlights a significant increase in side effects associated with amiodarone use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

4.

Intravenous amiodarone for ventricular arrhythmias: overview and clinical use.

Author: GonzalezE R, KannewurfB S, OrnatoJ P

Arrhythmia Treatment
Cardiac Arrest Survival

Intravenous amiodarone is an effective anti-arrhythmic agent for the acute treatment of life-threatening ventricular arrhythmias, such as ventricular tachycardia and fibrillation. The drug's efficacy has been demonstrated in clinical trials, including the ARREST trial which showed improved survival in amiodarone-treated patients following cardiac arrest.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

First clinical experience with the rapid-, short-acting amiodarone derivative E 047/1 after cardiac surgery.

Author: GombotzH, VicenziM, MahlaE, RehakP, MetzlerH

Easier to titrate
Effective against dysrhythmias
Many undesired side-effects
Poor pharmacodynamic properties

E 047/1, a derivative of amiodarone, is effective for treating cardiac dysrhythmias.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effects of amiodarone and diltiazem on persistent atrial fibrillation conversion and recurrence rates: a randomized controlled study.

Author: ManiosEmmanuel G, MavrakisHercules E, KanoupakisEmmanuel M, KallergisEleftherios M, DermitzakiDespina N, KambourakiDespina C, VardasPanos E

Increased conversion rate
Preserved sinus rhythm
Prolonged sinus rhythm

Oral amiodarone increases conversion rates, prolongs fibrillatory cycle length and atrial effective refractory period, and preserves sinus rhythm after cardioversion in persistent AF patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Individual patterns of dynamic QT/RR relationship in survivors of acute myocardial infarction and their relationship to antiarrhythmic efficacy of amiodarone.

Author: SmetanaPeter, PueyoEsther, HnatkovaKaterina, BatchvarovVelislav, LagunaPablo, MalikMarek

Effective antiarrhythmic drug
Serious side effects

Amiodarone, an antiarrhythmic drug, is effective in treating heart rhythm problems, but it has serious side effects. This study investigated whether certain markers could be used to predict which patients would not benefit from amiodarone treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

[Effects of amiodarone versus sotalol in treatment of atrial fibrillation: a random controlled clinical study].

Author: NiuFan, HuangCong-xin, JiangHong, YangBo, GuoWen-ling, ChenYun-xia, JinChun-rong, LiuZhuo-min

Atrial fibrillation conversion
Sinus rhythm maintenance
Bradycardia

Amiodarone is more effective than sotalol in converting atrial fibrillation to sinus rhythm and maintaining sinus rhythm. The adverse reaction of amiodarone on the heart is less severe than that of sotalol.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

9.

Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter.

Author: SinghBramah N, ConnollyStuart J, CrijnsHarry J G M, RoyDenis, KoweyPeter R, CapucciAlessandro, RadzikDavid, AliotEtienne M, HohnloserStefan H,

Reduced ventricular rate
Sinus rhythm maintenance
Pulmonary toxic effects
Thyroid and liver dysfunction

Dronedarone was significantly more effective than placebo in maintaining sinus rhythm and reducing ventricular rate during recurrence of arrhythmia. There was no evidence that dronedarone increased the risk of pulmonary toxicity, thyroid dysfunction, or liver dysfunction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Ocular Adverse Effects of Amiodarone: A Systematic Review of Case Reports.

Author: AlshehriMona, JouryAbdulaziz

amiodarone
ocular adverse effects

Cornea verticillata/vortex keratopathy was the most common ocular adverse effect of amiodarone, an antiarrhythmic medication, in 25 case reports. Early recognition of amiodarone-induced ocular adverse effects is crucial to prevent worsening keratopathy or other adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Amiodarone and/or lidocaine for cardiac arrest: A Bayesian network meta-analysis.

Author: ZhaoHongli, FanKai, FengGuilong

Increased hospital admission

This meta-analysis assessed the efficacy of amiodarone and/or lidocaine during cardiac arrest. While studies haven't shown improved long-term survival with antiarrhythmic drugs, some suggest higher hospitalization rates with amiodarone or lidocaine compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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