Paper Details

  1. Home
  2. Paper Details

Amiodarone and N-desethylamiodarone concentrations in plasma, red blood cells, and myocardium after a single oral dose: relation to hemodynamic effects in surgical patients.

Author: BergerY, ComminP, EchterE, EscoubetB, JaillonP, MenaschéP, PiwnicaA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oral amiodarone, an antiarrhythmic drug, was found to impair hemodynamics in surgical patients. The drug decreased cardiac index and heart rate, and increased capillary wedge pressure. Measuring amiodarone plasma concentration was the easiest method for monitoring the drug, but further investigation is needed to determine the clinical utility of drug monitoring during chronic administration.
Paper Details　
Original Abstract of the Article :
In an attempt to assess their respective values for purposes of drug monitoring, plasma, red blood cell, atrial, and ventricular concentrations of amiodarone and N-desethylamiodarone (NDA) were measured, in 50 surgical patients, after a single oral dose (30 mg/kg); hemodynamic changes were assessed ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0002-8703(86)90140-7

データ提供：米国国立医学図書館（NLM）

Amiodarone and its Effects on Hemodynamics in Surgical Patients

This study delves into the intricate world of pharmacology and surgery, investigating the hemodynamic effects of amiodarone, a medication used to treat heart rhythm disorders, in surgical patients. The researchers, like skilled surgeons carefully navigating a delicate procedure, sought to understand how amiodarone affects the heart's function during surgery.

Amiodarone's Impact on Hemodynamics

The study found that amiodarone administration decreased cardiac index and heart rate without significantly altering other hemodynamic parameters. The researchers also observed a relationship between amiodarone concentrations in plasma, red blood cells, and myocardium and an increase in capillary wedge pressure. This suggests that amiodarone, while effective in controlling heart rhythm, can have a complex impact on hemodynamics, much like a desert wind can have both beneficial and disruptive effects on the landscape.

Monitoring Amiodarone Use in Surgical Patients

The study highlights the importance of monitoring amiodarone concentrations in surgical patients to optimize treatment outcomes and minimize potential risks. This is like carefully monitoring the flow of water in a desert irrigation system to ensure the health of the crops. The researchers suggest that monitoring amiodarone plasma concentrations is the most practical method for monitoring the drug's effects during surgery.

Dr. Camel's Conclusion

This study offers valuable insights into the complex landscape of cardiac pharmacology and surgery. The researchers, like skilled surgeons carefully navigating a delicate procedure, meticulously evaluated the hemodynamic effects of amiodarone in surgical patients. Their findings underscore the importance of careful monitoring and management of amiodarone use to ensure patient safety and optimal treatment outcomes. As we continue to explore the vast desert of medical knowledge, we must always prioritize patient well-being and strive to optimize the effectiveness of our therapeutic interventions.
Date :
  1. Date Completed 1986-03-10
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

3946169

DOI: Digital Object Identifier

10.1016/0002-8703(86)90140-7

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.