Side Effects of amphotericin b injection: A Synthesis of Findings from 2 Studies

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Original Abstract of the Article

Main Research Findings

A retrospective cohort study has shown that retrobulbar amphotericin B injection may be effective in treating orbital infections in patients with invasive fungal rhinosinusitis with orbital invasion. 2

Reasons for Side Effects

Amphotericin B injection is an antifungal medication effective in treating fungal infections. However, like many other medications, amphotericin B injection can cause side effects.

Common Side Effects

Inflammation around the orbit

Amphotericin B injection can cause inflammation around the orbit. This is because amphotericin B directly acts on the tissues around the orbit. 2

Measures against Side Effects

Inflammation around the orbit

Steroids can be used to prevent or reduce inflammation around the orbit. Steroids are medications that suppress inflammation. 2

Comparison Between Studies

Common Points of Studies

These studies aim to evaluate the efficacy and safety of treatment methods for invasive fungal rhinosinusitis.

Differences in Studies

These studies evaluated the efficacy and safety of different treatments. 2 evaluated the efficacy of retrobulbar injection of amphotericin B. 1 evaluated the effects of using naltrexone and alprazolam in combination with amphetamine.

Notes on Application to Real Life

A retrospective cohort study has shown that retrobulbar amphotericin B injection may be effective in treating orbital infections in patients with invasive fungal rhinosinusitis with orbital invasion. 2 However, this study was a small study involving a limited number of patients, so further research is needed to fully understand the safety and efficacy of this drug.

Limitations of Current Research

Research on the side effects of amphotericin B injection is still limited. Further research is needed.

Future Research Directions

Further research on the side effects of amphotericin B injection is needed. Larger studies involving more patients are needed.

Conclusion

Amphotericin B injection may be effective in treating orbital infections in patients with invasive fungal rhinosinusitis with orbital invasion, but it is important to remember that there is also a risk of side effects. This treatment should be carefully considered, on a case-by-case basis, under the supervision of a physician.

Literature analysis of 2 papers
Positive Content
2
Neutral Content
0
Negative Content
0
Article Type
1
0
0
0
2
1.

Separate and combined impact of acute naltrexone and alprazolam on subjective and physiological effects of oral d-amphetamine in stimulant users.

Author: MarksKatherine R, LileJoshua A, StoopsWilliam W, RushCraig R

Stimulant abuse attenuation
Side effects

Opioid antagonists (e.g., naltrexone) and GABAA receptor modulators (e.g., alprazolam) can reduce stimulant abuse, but high doses lead to side effects. This article suggests combining naltrexone and alprazolam to maximize efficacy while avoiding side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

Efficacy and safety of retrobulbar amphotericin B injection in invasive fungal rhinosinusitis with orbital invasion patients.

Author: ArreenichP, SaonanonP, AeumjaturapatS, SnidvongsK, ChusakulS, KanjanaumpornJ

Orbital infection treatment
Side effects

This is the first retrospective cohort study to assess the efficacy and side effects of retrobulbar amphotericin B injection for orbital infection management in invasive fungal rhinosinusitis patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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