Paper Details

  1. Home
  2. Paper Details

Separate and combined impact of acute naltrexone and alprazolam on subjective and physiological effects of oral d-amphetamine in stimulant users.

Author: LileJoshua A, MarksKatherine R, RushCraig R, StoopsWilliam W

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Opioid antagonists (e.g., naltrexone) and GABAA receptor modulators (e.g., alprazolam) can reduce stimulant abuse, but high doses lead to side effects. This article suggests combining naltrexone and alprazolam to maximize efficacy while avoiding side effects.
Paper Details　
Original Abstract of the Article :
Opioid antagonists (e.g., naltrexone) and positive modulators of γ-aminobutyric-acidA (GABAA) receptors (e.g., alprazolam) modestly attenuate the abuse-related effects of stimulants like amphetamine. The use of higher doses to achieve greater efficacy is precluded by side effects. Combining naltrexo...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/24464531

データ提供：米国国立医学図書館（NLM）

The Desert of Addiction: Exploring the Effects of Naltrexone and Alprazolam on Amphetamine Use

Addiction, a complex and challenging condition, often involves a relentless pursuit of a desired substance or experience. This study delves into the effects of naltrexone and alprazolam, two drugs used to treat addiction, on the subjective and physiological effects of oral d-amphetamine in stimulant users. Researchers aim to understand how these drugs interact with amphetamine, hoping to develop more effective treatment strategies for those struggling with stimulant addiction. It's like exploring the vast and unforgiving desert of addiction, seeking to find pathways to recovery and a life free from dependence.

A New Pathway to Recovery: Investigating Naltrexone and Alprazolam's Impact on Amphetamine

The study investigates the combined effects of naltrexone and alprazolam on the effects of amphetamine, offering new insights into the potential for these drugs to reduce stimulant-related cravings and behaviors. These findings highlight the potential for a more effective treatment approach for stimulant addiction, offering a glimmer of hope for those seeking to overcome this challenging condition. It's like discovering a new pathway through the desert of addiction, leading to a more hopeful future for those seeking recovery.

Finding a Safe Haven: Addressing the Challenges of Stimulant Addiction

This research underscores the need for continued exploration of treatment options for stimulant addiction, a condition that can have devastating consequences for individuals and families. By understanding the effects of naltrexone and alprazolam on amphetamine, researchers can develop more effective treatment strategies, offering a safe haven for those struggling with this challenging condition. It's like finding a safe oasis in the desert of addiction, providing a place of peace and support for those seeking recovery.

Dr. Camel's Conclusion

This study offers promising insights into the potential of naltrexone and alprazolam to reduce the effects of amphetamine in stimulant users. The findings highlight the need for continued research and development of new treatment options, offering a beacon of hope for those seeking to overcome the challenges of addiction.

Date :
  1. Date Completed 2015-02-09
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24464531

DOI: Digital Object Identifier

NIHMS575285

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.