Effects of antipyrine-benzocaine otic: A Synthesis of Findings from 11 Studies

  1. Home
  2. Effects of antipyrine-benzocaine otic
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of antipyrine-benzocaine otic: A Synthesis of Findings from 11 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of antipyrine-benzocaine otic: A Synthesis of Findings from 11 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Amiodarone is a highly effective antiarrhythmic drug for various types of arrhythmias, particularly ventricular tachycardia and fibrillation. It is considered an important treatment option for emergency antiarrhythmic therapy in patients experiencing cardiac arrest, as shown by a study that found a significant improvement in survival rates for patients receiving IV amiodarone compared to placebo. 4

A study found that while amiodarone is effective in maintaining sinus rhythm in atrial fibrillation, it can be associated with potentially serious toxic effects. 9

Amiodarone's short-acting derivative, E 047/1, may be easier to titrate while maintaining its high efficacy. It might have acceptable effects on haemodynamics and cardiac conduction in patients experiencing serious ventricular arrhythmias after cardiac surgery. 5

While some studies have shown a higher rate of hospital admission with amiodarone or lidocaine compared to placebo, available research has not demonstrated that antiarrhythmic drugs can increase long-term survival or survival with favorable neurological outcomes. 11

Amiodarone can have a negative impact on hemodynamics, and measuring plasma concentrations rather than red blood cell concentrations might be the easiest way to monitor the drug. 1

Amiodarone's potential for serious side effects has led to concerns about its prophylactic use in survivors of acute myocardial infarction. 7

Lidocaine is still considered the preferred treatment for life-threatening ventricular arrhythmias during acute myocardial infarction due to its established efficacy and high therapeutic index. However, the efficacy of lidocaine and amiodarone, with different electrophysiological properties, were compared in patients with acute myocardial infarction. 2

A meta-analysis of randomized controlled trials found that amiodarone use in heart failure was associated with a reduction in deaths but also a significant increase in side effects. 3

A study aimed to evaluate the effects and adverse reactions of amiodarone and sotalol in the treatment of atrial fibrillation. 8

Benefits and Risks

Benefits Summary

Amiodarone is a proven effective treatment for various types of arrhythmias, particularly ventricular tachycardia and fibrillation. It is a crucial option for emergency antiarrhythmic therapy in patients experiencing cardiac arrest. Some studies suggest potential benefits in improving survival rates for chronic heart failure patients.

Risks Summary

Amiodarone carries a risk of serious side effects. The most common include lung problems, thyroid abnormalities, liver damage, and vision issues.

Comparison between Studies

Similarities

These studies all show that amiodarone is an effective antiarrhythmic drug but also raise concerns about its side effects.

Differences

These studies examine different aspects of amiodarone, including its side effects, administration methods, and specific indications. For instance, one study investigates the impact of amiodarone on the heart muscle, while another focuses on its effects on atrial fibrillation.

Consistency and Contradictions in Results

While the results consistently indicate amiodarone's effectiveness as an antiarrhythmic drug, they also highlight the potential for serious side effects. However, the severity and manifestation of these side effects can vary among patients and studies.

Considerations for Real-World Application

Due to the potential for severe side effects, it is crucial to use amiodarone under a doctor's supervision. Before taking amiodarone, inform your doctor about your medical history and any medications you are currently taking. Report any potential side effects to your doctor immediately.

Limitations of Current Research

These studies suggest the need for further research to gain a deeper understanding of amiodarone's effects and side effects.

Future Research Directions

Research is needed to explore ways to mitigate amiodarone's side effects and identify patients who are most likely to benefit from its use.

Conclusion

Amiodarone is a valuable antiarrhythmic medication, but it's important to use it responsibly due to the potential for serious side effects. Consult your doctor before taking amiodarone, provide them with your medical history and current medications, and report any potential side effects promptly.

Literature analysis of 11 papers
Positive Content
8
Neutral Content
0
Negative Content
3
Article Type
8
3
2
1
11
1.

Amiodarone and N-desethylamiodarone concentrations in plasma, red blood cells, and myocardium after a single oral dose: relation to hemodynamic effects in surgical patients.

Author: EscoubetB, JaillonP, BergerY, ComminP, MenaschéP, PiwnicaA, EchterE

Impaired hemodynamics

Oral amiodarone, an antiarrhythmic drug, was found to impair hemodynamics in surgical patients. The drug decreased cardiac index and heart rate, and increased capillary wedge pressure. Measuring amiodarone plasma concentration was the easiest method for monitoring the drug, but further investigation is needed to determine the clinical utility of drug monitoring during chronic administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Intravenous administration of lidocaine and amiodarone in patients with acute myocardial infarction].

Author: CapucciA, MelandriG, MantovaniB, MarestaA, MagnaniB

Reduced ventricular arrhythmias
Blood pressure decrease
QTc prolongation
Ventricular fibrillation

Amiodarone was as effective as lidocaine in treating life-threatening ventricular arrhythmias in patients with acute myocardial infarction. Amiodarone prolonged the QTc interval and slightly decreased systolic blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

3.

Overview and meta-analysis of randomised trials of amiodarone in chronic heart failure.

Author: PiepoliM, VillaniG Q, PonikowskiP, WrightA, FlatherM D, CoatsA J

Reduction in deaths
Increased side effects

This article reviews the use of amiodarone in patients with heart failure. While meta-analysis suggests a significant reduction in deaths, it also highlights a significant increase in side effects associated with amiodarone use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

4.

Intravenous amiodarone for ventricular arrhythmias: overview and clinical use.

Author: GonzalezE R, KannewurfB S, OrnatoJ P

Arrhythmia Treatment
Cardiac Arrest Survival

Intravenous amiodarone is an effective anti-arrhythmic agent for the acute treatment of life-threatening ventricular arrhythmias, such as ventricular tachycardia and fibrillation. The drug's efficacy has been demonstrated in clinical trials, including the ARREST trial which showed improved survival in amiodarone-treated patients following cardiac arrest.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

First clinical experience with the rapid-, short-acting amiodarone derivative E 047/1 after cardiac surgery.

Author: GombotzH, VicenziM, MahlaE, RehakP, MetzlerH

Easier to titrate
Effective against dysrhythmias
Many undesired side-effects
Poor pharmacodynamic properties

E 047/1, a derivative of amiodarone, is effective for treating cardiac dysrhythmias.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effects of amiodarone and diltiazem on persistent atrial fibrillation conversion and recurrence rates: a randomized controlled study.

Author: ManiosEmmanuel G, MavrakisHercules E, KanoupakisEmmanuel M, KallergisEleftherios M, DermitzakiDespina N, KambourakiDespina C, VardasPanos E

Increased conversion rate
Preserved sinus rhythm
Prolonged sinus rhythm

Oral amiodarone increases conversion rates, prolongs fibrillatory cycle length and atrial effective refractory period, and preserves sinus rhythm after cardioversion in persistent AF patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Individual patterns of dynamic QT/RR relationship in survivors of acute myocardial infarction and their relationship to antiarrhythmic efficacy of amiodarone.

Author: SmetanaPeter, PueyoEsther, HnatkovaKaterina, BatchvarovVelislav, LagunaPablo, MalikMarek

Effective antiarrhythmic drug
Serious side effects

Amiodarone, an antiarrhythmic drug, is effective in treating heart rhythm problems, but it has serious side effects. This study investigated whether certain markers could be used to predict which patients would not benefit from amiodarone treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

[Effects of amiodarone versus sotalol in treatment of atrial fibrillation: a random controlled clinical study].

Author: NiuFan, HuangCong-xin, JiangHong, YangBo, GuoWen-ling, ChenYun-xia, JinChun-rong, LiuZhuo-min

Atrial fibrillation conversion
Sinus rhythm maintenance
Bradycardia

Amiodarone is more effective than sotalol in converting atrial fibrillation to sinus rhythm and maintaining sinus rhythm. The adverse reaction of amiodarone on the heart is less severe than that of sotalol.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

9.

Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter.

Author: SinghBramah N, ConnollyStuart J, CrijnsHarry J G M, RoyDenis, KoweyPeter R, CapucciAlessandro, RadzikDavid, AliotEtienne M, HohnloserStefan H,

Reduced ventricular rate
Sinus rhythm maintenance
Pulmonary toxic effects
Thyroid and liver dysfunction

Dronedarone was significantly more effective than placebo in maintaining sinus rhythm and reducing ventricular rate during recurrence of arrhythmia. There was no evidence that dronedarone increased the risk of pulmonary toxicity, thyroid dysfunction, or liver dysfunction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Ocular Adverse Effects of Amiodarone: A Systematic Review of Case Reports.

Author: AlshehriMona, JouryAbdulaziz

amiodarone
ocular adverse effects

Cornea verticillata/vortex keratopathy was the most common ocular adverse effect of amiodarone, an antiarrhythmic medication, in 25 case reports. Early recognition of amiodarone-induced ocular adverse effects is crucial to prevent worsening keratopathy or other adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Amiodarone and/or lidocaine for cardiac arrest: A Bayesian network meta-analysis.

Author: ZhaoHongli, FanKai, FengGuilong

Increased hospital admission

This meta-analysis assessed the efficacy of amiodarone and/or lidocaine during cardiac arrest. While studies haven't shown improved long-term survival with antiarrhythmic drugs, some suggest higher hospitalization rates with amiodarone or lidocaine compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.