Main Research Findings

Here are the main research findings on the side effects of aprocitentan.

• 2 suggests that regular use of low-dose aspirin is recommended for several groups of patients at risk of vascular occlusion. However, the optimal dose of aspirin to produce a cardiovascular benefit while minimizing side effects is uncertain. Furthermore, while enteric-coated preparations may reduce gastrointestinal symptoms, the antiplatelet effects of these formulations have not been completely tested. In addition, there is exceptionally little data relating to these issues in women.
• 1 reports that in a clinical trial of two antirheumatic agents, two methods of collecting side effects were used: one with and the other without a checklist of possible symptoms. Findings suggested that the use of a checklist interfered with the collection of side effects. Known side effects of aspirin – tinnitus, deafness, and gastrointestinal disturbance – were more efficiently shown, and symptoms not included in the checklist were more likely to be reported when a checklist was not used.

Reasons for Side Effects

The reasons for the side effects of aprocitentan vary depending on how the drug acts in the body. Aspirin works by inhibiting platelet aggregation. This is because aspirin binds to platelets, preventing them from sticking together. This action can increase the risk of bleeding. Aspirin can also damage the lining of the stomach, leading to side effects such as stomach pain and indigestion.

Common Side Effects

Stomach Pain

Aspirin can damage the lining of the stomach. This is because aspirin increases the secretion of stomach acid. Stomach pain is one of the most common side effects of aspirin. 1

Indigestion

Aspirin can cause indigestion. This is because aspirin inhibits the action of digestive enzymes in the stomach. 1

Tinnitus

Aspirin can cause tinnitus and hearing loss. This is because aspirin damages the hair cells in the inner ear. 1

Bleeding

Aspirin can increase the risk of bleeding. This is because aspirin inhibits platelet aggregation. Bleeding can lead to serious problems such as stomach ulcers and strokes. 2

Side Effect Countermeasures

Countermeasures for Stomach Pain

To prevent stomach pain, it is recommended to take aspirin with food or with milk or water. It is also effective to use enteric-coated aspirin. 2

Countermeasures for Indigestion

To prevent indigestion, it is recommended to take aspirin with food. It is also effective to use enteric-coated aspirin. 2

Countermeasures for Tinnitus

If you experience tinnitus, stop taking aspirin and consult your doctor. 1

Countermeasures for Bleeding

If you suspect bleeding, consult your doctor immediately. 2

Comparison Between Studies

Commonalities Between Studies

Both studies provide important information regarding the side effects of aspirin. 2 and 1

Differences Between Studies

Study 1 2 highlights that regular use of low-dose aspirin is recommended for several groups of patients at risk of vascular occlusion. Study 2 1 demonstrates that the method of collecting side effects can affect how side effects are reported.

Points to Note Regarding Application to Real Life

Aspirin has many health benefits but also carries the risk of side effects. If you are considering taking aspirin, talk to your doctor to see if it is the right option for you. Also, if you take aspirin, follow your doctor's instructions and be aware of potential side effects. 2 and 1

Limitations of Current Research

These studies have several limitations. For example, Study 1 2 has limited data on women, so it cannot draw conclusions about the effects of aspirin on women. Study 2 1 suggests that the use of a checklist interferes with the collection of side effects, but it does not provide detailed information on how the checklist was used or what its contents were.

Future Research Directions

Future research should investigate the optimal dose of aspirin. It is also necessary to elucidate the mechanisms of aspirin side effects and develop safer ways to administer aspirin. Furthermore, by increasing the amount of data on women, we can gain a deeper understanding of the effects of aspirin on women.

Conclusion

Aspirin has many health benefits, but it also carries the risk of side effects. If you are considering taking aspirin, talk to your doctor to see if it is the right option for you. Also, if you take aspirin, follow your doctor's instructions and be aware of potential side effects.