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Measurement of side effects of drugs.

Author: HuskissonE C, WojtulewskiJ A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Using a check list to collect side effects in a clinical trial may interfere with the reporting of known and unknown symptoms.
Paper Details　
Original Abstract of the Article :
In a clinical trial of two antirheumatic agents two methods of collection of side effects were used, one with and the other without a check list of possible symptoms. Findings suggested that the use of a check list interfered with the collection of side effects. Known side effects of aspirin-tinnitu...See full text at original site
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引用元：
https://doi.org/10.1136/bmj.2.5921.698

データ提供：米国国立医学図書館（NLM）

Side Effects: A Challenging Aspect of Drug Development

The development and evaluation of new drugs involves a careful assessment of their potential side effects. This study explores the impact of [checklists] on the collection of side effects in a clinical trial of two antirheumatic agents. The researchers found that the use of checklists interfered with the reporting of side effects, with some known side effects being underreported and other unexpected symptoms being overlooked. This study highlights the importance of using multiple methods for collecting side effect information and avoiding reliance on pre-defined checklists.

Checklists: A Double-Edged Sword in Side Effect Reporting

Checklists can be helpful tools in research, but their use in collecting side effect information can lead to biased results. This study suggests that checklists can hinder the identification of unexpected side effects and limit the completeness of side effect reporting. Therefore, researchers need to be cautious about relying solely on checklists when assessing the safety of new drugs.

Side Effects: A Desert of Unforeseen Consequences

The desert of drug development is full of surprises. Just as a camel can encounter unexpected obstacles in the desert, researchers can encounter unexpected side effects during drug development. This study emphasizes the importance of thorough and unbiased methods for identifying and reporting side effects to ensure the safety and efficacy of new drugs.

Dr.Camel's Conclusion

The desert of drug development is a complex and challenging landscape. Researchers need to be vigilant in their pursuit of new therapies, carefully considering the potential side effects and using a comprehensive approach to ensure the safety and well-being of patients.

Date :
  1. Date Completed 1974-10-25
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

4853118

DOI: Digital Object Identifier

10.1136/bmj.2.5921.698

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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