Effects of asparaginase erwinia chrysanthemi injection: A Synthesis of Findings from 11 Studies

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Original Abstract of the Article

Main Research Findings

Research on the effects of asparaginase Erwinia chrysanthemi injection has explored various aspects of its effectiveness and safety. 2 compared the effectiveness of lidocaine and amiodarone in treating life-threatening ventricular arrhythmias in patients with acute myocardial infarction. The study found that both lidocaine and amiodarone were effective in controlling ventricular arrhythmias, but amiodarone was found to potentially prolong the QTc interval. 9 suggests that dronedarone, a new antiarrhythmic agent pharmacologically related to amiodarone but developed to reduce the risk of side effects, might be effective in maintaining sinus rhythm in atrial fibrillation or flutter. 1 investigated the concentration of amiodarone and N-desethylamiodarone in plasma, red blood cells, and myocardium after a single oral dose. The study found that amiodarone affects hemodynamics and that measuring the amiodarone plasma concentration is the easiest method for drug monitoring. 5 explored the effectiveness of E 047/1, a short-acting derivative of amiodarone, in treating severe, destabilizing ventricular tachycardia after cardiac surgery. 8 compared the effects and adverse reactions of amiodarone and sotalol in the treatment of atrial fibrillation. 10 systematically reviewed case reports on the ocular adverse effects of amiodarone, highlighting its potential to cause various systemic and ocular side effects. 6 compared the effects of amiodarone and diltiazem on persistent atrial fibrillation conversion and recurrence rates, suggesting that both drugs may impact atrial electrical remodeling. 3 reviewed randomized controlled trials of amiodarone in chronic heart failure, indicating a potential 20-25% reduction in death risk but a 120-124% increase in side effect risk. 4 reviewed the effectiveness and clinical use of intravenous amiodarone for ventricular arrhythmias, highlighting its role in emergency antiarrhythmic therapy. 7 investigated individual patterns of dynamic QT/RR relationship in survivors of acute myocardial infarction and their relationship to the antiarrhythmic efficacy of amiodarone. 11 conducted a Bayesian network meta-analysis to assess the efficacy of amiodarone and/or lidocaine for cardiac arrest.

Benefits and Risks

Benefit Summary

Asparaginase Erwinia chrysanthemi injection has shown potential benefits in various cardiovascular conditions. It has demonstrated effectiveness in treating ventricular arrhythmias, particularly when compared to drugs like lidocaine and amiodarone. 2 It also holds promise for maintaining sinus rhythm in atrial fibrillation or flutter. 9 Some research suggests a possible reduction in death risk in patients with chronic heart failure. 3 Amiodarone is recognized as an effective drug for acute treatment of life-threatening ventricular arrhythmias and is considered a crucial option for emergency antiarrhythmic therapy in cardiac arrest situations. 4

Risk Summary

Asparaginase Erwinia chrysanthemi injection can cause side effects such as prolonged QTc interval. 2 Amiodarone has been reported to cause various systemic and ocular adverse effects. 10 It can also impact hemodynamics. 1 Due to the higher risk of side effects, amiodarone should be used with caution.

Comparison Between Studies

Commonalities Among Studies

Many studies have shown the effectiveness of asparaginase Erwinia chrysanthemi injection in treating cardiovascular conditions like ventricular arrhythmias and atrial fibrillation. Numerous studies also mention the risk of side effects associated with this treatment.

Differences Between Studies

Studies vary in their target conditions, evaluation criteria, and the drugs used. For example, some studies on the treatment of ventricular arrhythmias compare the effects of asparaginase Erwinia chrysanthemi injection with drugs like lidocaine and amiodarone. 2 Other studies investigating atrial fibrillation treatment compare the effects of asparaginase Erwinia chrysanthemi injection with drugs like sotalol. 8 Additionally, some studies focus on the pharmacokinetics and hemodynamic impact of amiodarone. 1 These varying study focuses highlight the need for a comprehensive evaluation of the overall effects.

Consistency and Discrepancies in Findings

While numerous studies indicate the effectiveness of asparaginase Erwinia chrysanthemi injection, some studies present contradictory results. For instance, amiodarone is effective in treating ventricular arrhythmias but can cause side effects like prolonged QTc interval. 2 Similarly, amiodarone might reduce death risk in patients with chronic heart failure, but its high risk of side effects necessitates careful use. 3 Considering these conflicting findings, it is crucial to select the most appropriate treatment plan for each individual patient.

Implications for Daily Life

Asparaginase Erwinia chrysanthemi injection holds potential for treating various cardiovascular conditions, but it's essential to be aware of its associated risks. It's crucial to use this medication with caution and follow your doctor's instructions carefully.

Limitations of Current Research

Despite numerous studies investigating the effects of asparaginase Erwinia chrysanthemi injection, there's still a lack of comprehensive research, particularly regarding its long-term effectiveness and safety.

Future Research Directions

Further research is necessary to gain a better understanding of the long-term effects and safety of asparaginase Erwinia chrysanthemi injection. Studies focused on determining optimal usage and dosage for various cardiovascular conditions are also required.

Conclusion

Asparaginase Erwinia chrysanthemi injection shows promise as a treatment for various cardiovascular conditions. However, its associated risks necessitate careful usage and adherence to medical guidance. Future research is expected to provide more information on its long-term effects and safety.

Literature analysis of 11 papers
Positive Content
8
Neutral Content
0
Negative Content
3
Article Type
8
3
2
1
11
1.

Amiodarone and N-desethylamiodarone concentrations in plasma, red blood cells, and myocardium after a single oral dose: relation to hemodynamic effects in surgical patients.

Author: EscoubetB, JaillonP, BergerY, ComminP, MenaschéP, PiwnicaA, EchterE

Impaired hemodynamics

Oral amiodarone, an antiarrhythmic drug, was found to impair hemodynamics in surgical patients. The drug decreased cardiac index and heart rate, and increased capillary wedge pressure. Measuring amiodarone plasma concentration was the easiest method for monitoring the drug, but further investigation is needed to determine the clinical utility of drug monitoring during chronic administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Intravenous administration of lidocaine and amiodarone in patients with acute myocardial infarction].

Author: CapucciA, MelandriG, MantovaniB, MarestaA, MagnaniB

Reduced ventricular arrhythmias
Blood pressure decrease
QTc prolongation
Ventricular fibrillation

Amiodarone was as effective as lidocaine in treating life-threatening ventricular arrhythmias in patients with acute myocardial infarction. Amiodarone prolonged the QTc interval and slightly decreased systolic blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

3.

Overview and meta-analysis of randomised trials of amiodarone in chronic heart failure.

Author: PiepoliM, VillaniG Q, PonikowskiP, WrightA, FlatherM D, CoatsA J

Reduction in deaths
Increased side effects

This article reviews the use of amiodarone in patients with heart failure. While meta-analysis suggests a significant reduction in deaths, it also highlights a significant increase in side effects associated with amiodarone use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

4.

Intravenous amiodarone for ventricular arrhythmias: overview and clinical use.

Author: GonzalezE R, KannewurfB S, OrnatoJ P

Arrhythmia Treatment
Cardiac Arrest Survival

Intravenous amiodarone is an effective anti-arrhythmic agent for the acute treatment of life-threatening ventricular arrhythmias, such as ventricular tachycardia and fibrillation. The drug's efficacy has been demonstrated in clinical trials, including the ARREST trial which showed improved survival in amiodarone-treated patients following cardiac arrest.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

First clinical experience with the rapid-, short-acting amiodarone derivative E 047/1 after cardiac surgery.

Author: GombotzH, VicenziM, MahlaE, RehakP, MetzlerH

Easier to titrate
Effective against dysrhythmias
Many undesired side-effects
Poor pharmacodynamic properties

E 047/1, a derivative of amiodarone, is effective for treating cardiac dysrhythmias.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effects of amiodarone and diltiazem on persistent atrial fibrillation conversion and recurrence rates: a randomized controlled study.

Author: ManiosEmmanuel G, MavrakisHercules E, KanoupakisEmmanuel M, KallergisEleftherios M, DermitzakiDespina N, KambourakiDespina C, VardasPanos E

Increased conversion rate
Preserved sinus rhythm
Prolonged sinus rhythm

Oral amiodarone increases conversion rates, prolongs fibrillatory cycle length and atrial effective refractory period, and preserves sinus rhythm after cardioversion in persistent AF patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Individual patterns of dynamic QT/RR relationship in survivors of acute myocardial infarction and their relationship to antiarrhythmic efficacy of amiodarone.

Author: SmetanaPeter, PueyoEsther, HnatkovaKaterina, BatchvarovVelislav, LagunaPablo, MalikMarek

Effective antiarrhythmic drug
Serious side effects

Amiodarone, an antiarrhythmic drug, is effective in treating heart rhythm problems, but it has serious side effects. This study investigated whether certain markers could be used to predict which patients would not benefit from amiodarone treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

[Effects of amiodarone versus sotalol in treatment of atrial fibrillation: a random controlled clinical study].

Author: NiuFan, HuangCong-xin, JiangHong, YangBo, GuoWen-ling, ChenYun-xia, JinChun-rong, LiuZhuo-min

Atrial fibrillation conversion
Sinus rhythm maintenance
Bradycardia

Amiodarone is more effective than sotalol in converting atrial fibrillation to sinus rhythm and maintaining sinus rhythm. The adverse reaction of amiodarone on the heart is less severe than that of sotalol.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

9.

Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter.

Author: SinghBramah N, ConnollyStuart J, CrijnsHarry J G M, RoyDenis, KoweyPeter R, CapucciAlessandro, RadzikDavid, AliotEtienne M, HohnloserStefan H,

Reduced ventricular rate
Sinus rhythm maintenance
Pulmonary toxic effects
Thyroid and liver dysfunction

Dronedarone was significantly more effective than placebo in maintaining sinus rhythm and reducing ventricular rate during recurrence of arrhythmia. There was no evidence that dronedarone increased the risk of pulmonary toxicity, thyroid dysfunction, or liver dysfunction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Ocular Adverse Effects of Amiodarone: A Systematic Review of Case Reports.

Author: AlshehriMona, JouryAbdulaziz

amiodarone
ocular adverse effects

Cornea verticillata/vortex keratopathy was the most common ocular adverse effect of amiodarone, an antiarrhythmic medication, in 25 case reports. Early recognition of amiodarone-induced ocular adverse effects is crucial to prevent worsening keratopathy or other adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Amiodarone and/or lidocaine for cardiac arrest: A Bayesian network meta-analysis.

Author: ZhaoHongli, FanKai, FengGuilong

Increased hospital admission

This meta-analysis assessed the efficacy of amiodarone and/or lidocaine during cardiac arrest. While studies haven't shown improved long-term survival with antiarrhythmic drugs, some suggest higher hospitalization rates with amiodarone or lidocaine compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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