Side Effects of asthma: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Major Research Findings

Several studies have shown the effectiveness of inhaled corticosteroids in treating asthma. They help reduce airway inflammation, improve lung function, and reduce asthma attacks. However, inhaled corticosteroids can cause side effects. These side effects are typically mild and temporary, but can be serious in some cases. 3 , 5 , 7 , 6 , 4 , 2 , 8 , 1

Reasons for side effects

Inhaled corticosteroids work by reducing airway inflammation. However, these medications can affect the entire body. This is because inhaled corticosteroids can be absorbed from the airways into the bloodstream. Once in the bloodstream, inhaled corticosteroids can affect other tissues in the body. 3 , 5 , 7 , 6 , 4 , 2 , 8 , 1

Common side effects

Hoarseness

Inhaled corticosteroids can cause hoarseness. This is because the steroid can affect the tissues of the vocal cords. Hoarseness from steroids is usually mild and temporary. However, prolonged use of steroids can lead to severe hoarseness. 5

Oral candidiasis

Inhaled corticosteroids can cause oral candidiasis. This is because the steroid can disrupt the balance of bacteria in the mouth, promoting the growth of Candida fungi. Oral candidiasis is usually mild and can be treated with antifungal medications. 5

Adrenal suppression

Inhaled corticosteroids can cause adrenal suppression. This is because the steroid can suppress the production of cortisol from the adrenal glands. Adrenal suppression is usually mild and resolves when the steroid is discontinued. However, prolonged use of steroids can lead to severe adrenal suppression. 3 , 6 , 4 , 8

Osteoporosis

Inhaled corticosteroids can cause osteoporosis. This is because the steroid can suppress bone formation and promote bone absorption. Osteoporosis is usually mild and can be prevented by consuming calcium and vitamin D. However, prolonged use of steroids can lead to severe osteoporosis. 4

Cataracts

Inhaled corticosteroids can cause cataracts. This is because the steroid can affect the lens of the eye. Cataracts are usually mild and can be treated with surgery. However, prolonged use of steroids can lead to severe cataracts. 5

Glaucoma

Inhaled corticosteroids can cause glaucoma. This is because the steroid can affect eye pressure. Glaucoma is usually mild and can be treated with eye drops. However, prolonged use of steroids can lead to severe glaucoma. 5

Gastrointestinal symptoms

Inhaled corticosteroids can cause gastrointestinal symptoms. This is because the steroid can affect the lining of the stomach. Gastrointestinal symptoms are usually mild and can be treated with antacids. However, prolonged use of steroids can lead to severe gastrointestinal symptoms. 6

Mental effects

Inhaled corticosteroids can cause mental effects. This is because the steroid can affect the brain. Mental effects are usually mild and resolve when the steroid is discontinued. However, prolonged use of steroids can lead to severe mental effects. 2

Side effect management

Hoarseness

To prevent hoarseness from inhaled corticosteroids, it is important to follow proper usage instructions. When using inhaled corticosteroids, rinse your mouth and gargle. Also, follow your doctor's instructions when using inhaled corticosteroids. 5

Oral candidiasis

To prevent oral candidiasis from inhaled corticosteroids, it is important to follow proper usage instructions. When using inhaled corticosteroids, rinse your mouth and gargle. Also, follow your doctor's instructions when using inhaled corticosteroids. If oral candidiasis occurs, use antifungal medications. 5

Adrenal suppression

To prevent adrenal suppression from inhaled corticosteroids, it is important to follow proper usage instructions. Follow your doctor's instructions when using inhaled corticosteroids. Also, get regular blood tests to ensure your adrenal function remains normal while using inhaled corticosteroids. 3 , 6 , 4 , 8

Osteoporosis

To prevent osteoporosis from inhaled corticosteroids, it is important to consume enough calcium and vitamin D. It is also important to get regular bone density tests to detect osteoporosis early. 4

Cataracts

To prevent cataracts from inhaled corticosteroids, it is important to get regular eye exams. If cataracts occur, they can be treated with surgery. 5

Glaucoma

To prevent glaucoma from inhaled corticosteroids, it is important to get regular eye exams. If glaucoma occurs, it can be treated with eye drops. 5

Gastrointestinal symptoms

To prevent gastrointestinal symptoms from inhaled corticosteroids, it is important to pay attention to your diet and use antacids. If gastrointestinal symptoms occur, consult your doctor. 6

Mental effects

To prevent mental effects from inhaled corticosteroids, it is important to reduce mental stress. If mental effects occur, consult your doctor. 2

Research comparison

Research Similarities

Many studies have shown that inhaled corticosteroids are effective in treating asthma. They can also cause side effects. These side effects are usually mild and temporary, but can become serious in some cases. 3 , 5 , 7 , 6 , 4 , 2 , 8 , 1

Research Differences

The effects and side effects of inhaled corticosteroids may differ depending on the study. This is because the type of inhaled corticosteroid used, the study subjects, and the research methods may differ. More research is needed to investigate the side effects of inhaled corticosteroids in more detail. 3 , 5 , 7 , 6 , 4 , 2 , 8 , 1

Notes on real-life application

Inhaled corticosteroids are effective medications for treating asthma. However, inhaled corticosteroids have side effects. When using inhaled corticosteroids, it is important to consider the risks and benefits of side effects and to follow proper usage instructions after consulting with your doctor. 3 , 5 , 7 , 6 , 4 , 2 , 8 , 1

Current research limitations

There is not enough research on inhaled corticosteroids yet. Research on the long-term effects and side effects of inhaled corticosteroids is limited. More research is needed to investigate the safety and effectiveness of inhaled corticosteroids in greater detail. 3 , 5 , 7 , 6 , 4 , 2 , 8 , 1

Future research directions

It is necessary to conduct research on the long-term effects and side effects of inhaled corticosteroids. It is also important to develop new drugs and treatments that improve the safety and effectiveness of inhaled corticosteroids. 3 , 5 , 7 , 6 , 4 , 2 , 8 , 1

Conclusion

Inhaled corticosteroids are effective medications for treating asthma, but they can cause side effects. When using inhaled corticosteroids, it is important to consider the risks and benefits of side effects and to follow proper usage instructions after consulting with your doctor. More research is needed to investigate the safety and effectiveness of inhaled corticosteroids in greater detail. 3 , 5 , 7 , 6 , 4 , 2 , 8 , 1

Literature analysis of 8 papers
Positive Content
7
Neutral Content
0
Negative Content
1
Article Type
7
1
1
1
8
1.

[Inhaled corticotherapy sparing effect by sodium nedocromil in moderate to severe asthma].

Author: MurcianoD, BraunsteinG, MontagutA, ParienteR

Asthma improvement
Steroid sparing effect

Nedocromil sodium was effective in improving moderate to severe asthma in addition to inhaled steroids and had some steroid-sparing effect in patients treated with high-dose inhaled steroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

2.

Neuropsychological and behavioral changes in asthmatic children treated with beclomethasone dipropionate versus theophylline.

Author: BenderB G, IkléD N, DuHamelT, TinkelmanD

Psychological side effects

The relative psychological side effects of theophylline and beclomethasone in asthmatic children need further investigation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Fluticasone propionate powder: oral corticosteroid-sparing effect and improved lung function and quality of life in patients with severe chronic asthma.

Author: NelsonH S, BusseW W, deBoisblancB P, BergerW E, NoonanM J, WebbD R, WolfordJ P, MahajanP S, HamedaniA G, ShahT, HardingS M

Asthma-specific quality of life
Improved lung function
Prednisone withdrawal
Topical effects

Fluticasone propionate powder (500 or 1000 microg twice daily) effectively improved lung function, adrenal function, and asthma-specific quality of life in patients with severe chronic asthma previously treated with oral prednisone while allowing most patients to be weaned off oral corticosteroid therapy. In a study of 111 patients with severe chronic asthma, oral prednisone was eliminated by 75% and 89% of patients in the twice daily 500 and 1000 microg fluticasone propionate groups, respectively, versus 9% of the placebo group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The effectiveness of high-dose inhaled budesonide therapy in the treatment of acute asthma exacerbations in children.

Author: NuhoğluY, BahçecilerN N, BarlanI B, Müjdat BaşaranM

Effective treatment of asthma
Corticosteroid-induced side effects

Guidelines recommend using corticosteroids to treat severe asthma attacks that don’t improve within 24-36 hours of home treatment. While this treatment is unlikely to cause serious problems for infrequent asthma attacks, frequent use can lead to side effects such as adrenal suppression, growth delays, and bone thinning.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Inhaled beclomethasone dipropionate improves acoustic measures of voice in patients with asthma.

Author: BalterM S, AdamsS G, ChapmanK R

Improves voice

Inhaled beclomethasone dipropionate (BDP) improves specific acoustic measures of voice in patients with inadequately controlled asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma.

Author: SzeflerStanley, RohatagiShashank, WilliamsJames, LloydMark, KunduSudeep, BanerjiDonald

No adrenal suppression
Reduces airway inflammation

This study found that treatment with moderate and high doses of ciclesonide does not result in hypothalamic-pituitary-adrenal-axis suppression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Nedocromil sodium for chronic asthma in children.

Author: SridharA V, McKeanM

Asthma treatment
Long-term side effects

This study highlights the need for further research on the long-term side effects of inhaled corticosteroids in treating chronic asthma in children, emphasizing the importance of long-term safety monitoring for this commonly used medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Similar efficacy of ciclesonide versus prednisolone to treat asthma worsening after steroid tapering.

Author: van den BergeM, ArshadS H, IndP W, MagnussenH, HamelmannE, KanniessF, PostmaD S

Improved asthma control
Rapid onset of action
Reduced cortisol suppression
None reported

Inhaled ciclesonide (800mug twice daily) was as effective as oral prednisolone (40mg once daily) in regaining asthma control in patients with asthma worsening, with a more rapid onset and smaller effect on cortisol suppression, suggesting a better safety profile.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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