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Similar efficacy of ciclesonide versus prednisolone to treat asthma worsening after steroid tapering.

Author: ArshadS H, HamelmannE, IndP W, KanniessF, MagnussenH, PostmaD S, van den BergeM

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Inhaled ciclesonide (800mug twice daily) was as effective as oral prednisolone (40mg once daily) in regaining asthma control in patients with asthma worsening, with a more rapid onset and smaller effect on cortisol suppression, suggesting a better safety profile.
Paper Details　
Original Abstract of the Article :
RATIONALE: Oral corticosteroids effectively treat asthma exacerbations but are associated with well-described side effects. OBJECTIVE: This study compared the efficacy and safety of a high dose of an inhaled corticosteroid with oral prednisolone in patients with worsening of their asthma after medi...See full text at original site
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引用元：
https://doi.org/10.1016/j.rmed.2009.01.024

データ提供：米国国立医学図書館（NLM）

Ciclesonide vs. Prednisolone for Asthma: Inhaled vs. Oral Corticosteroids

Asthma is a chronic respiratory condition that requires careful management. Oral corticosteroids are often used to treat asthma exacerbations, but they can have significant side effects. This study compares the efficacy and safety of inhaled ciclesonide with oral prednisolone in patients experiencing worsening asthma after steroid tapering. The researchers randomly assigned patients to receive either ciclesonide or prednisolone for two weeks, monitoring their asthma symptoms and lung function. Their results indicate that ciclesonide is as effective as prednisolone in improving asthma control, with a faster onset of action and fewer side effects.

Inhaled Ciclesonide: A Promising Alternative for Asthma Control

The study's findings highlight the potential benefits of inhaled ciclesonide as a viable alternative to oral prednisolone for treating asthma exacerbations. The study found that ciclesonide was as effective as prednisolone in improving lung function and reducing asthma symptoms, with a faster onset of action and a smaller effect on cortisol levels. These findings suggest that inhaled ciclesonide might offer a safer and more convenient treatment option for patients with asthma.

Navigating the Treatment Landscape for Asthma

This research underscores the importance of considering different treatment options for asthma, particularly the potential benefits of inhaled corticosteroids. The study's findings encourage further research to explore the long-term efficacy and safety of inhaled ciclesonide in managing asthma, aiming to develop more effective and well-tolerated treatment approaches.

Dr.Camel's Conclusion

This study reminds us that finding the right treatment approach for asthma can be like searching for a hidden oasis in a vast desert. Inhaled ciclesonide offers a promising path to managing asthma exacerbations, potentially providing a more comfortable and effective journey for patients. Further research is crucial to fully explore its potential benefits and ensure the best possible outcomes for individuals living with asthma.

Date :
  1. Date Completed 2010-08-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19297141

DOI: Digital Object Identifier

10.1016/j.rmed.2009.01.024

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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