Side Effects of astrology: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Key Research Findings

Several studies have indicated that the long-term side effects of inhaled corticosteroids in the treatment of chronic asthma in children are not fully understood. 7 . Some research suggests that prolonged use of inhaled corticosteroids might be linked to side effects such as adrenal suppression, growth retardation, and osteoporosis. 4 . Other studies have shown that inhaled corticosteroids can also lead to upper respiratory tract side effects like hoarseness. 5 . However, some studies have found that inhaled corticosteroids actually improve specific acoustic measures of voice. 5 .

Reasons for Side Effects

The side effects of inhaled corticosteroids can be attributed to how the steroids are absorbed by the body. When inhaled corticosteroids are administered directly into the lungs, they can be absorbed systemically, potentially leading to side effects such as adrenal suppression. 4 . Inhaled corticosteroids can also affect tissues in the upper airway, such as the vocal cords. 5 .

Common Side Effects

Adrenal Suppression

Adrenal suppression can occur with long-term use of inhaled corticosteroids. 4 . This is a condition where the adrenal glands in the body are unable to produce enough hormones such as cortisol. Symptoms of adrenal suppression include fatigue, weight loss, muscle weakness, and depression.

Growth Retardation

Growth retardation can occur with long-term use of inhaled corticosteroids. 4 . This is because steroids can inhibit bone growth. Growth retardation can be particularly problematic in children and adolescents.

Osteoporosis

Osteoporosis can occur with long-term use of inhaled corticosteroids. 4 . This is because steroids can decrease the strength of bones. Symptoms of osteoporosis include increased susceptibility to fractures.

Hoarseness

Hoarseness can be caused by inhaled corticosteroids. 5 . This is because steroids can cause inflammation of the vocal cords.

Countermeasures for Side Effects

Countermeasures for Adrenal Suppression

Countermeasures for adrenal suppression include reducing the amount of steroids or temporarily stopping the steroids. 4 . It is also important to consult a doctor if symptoms of adrenal suppression appear.

Countermeasures for Growth Retardation

Countermeasures for growth retardation include reducing the amount of steroids or temporarily stopping the steroids. 4 . It is also important to check the child's growth regularly.

Countermeasures for Osteoporosis

Countermeasures for osteoporosis include taking calcium and vitamin D. 4 . It is also important to exercise regularly to maintain bone health.

Countermeasures for Hoarseness

Countermeasures for hoarseness include consulting a doctor if hoarseness persists. 5 .

Comparison between Studies

Commonalities between Studies

All of these studies have shown that inhaled corticosteroids are effective in treating asthma. However, these studies have also shown that long-term use of inhaled corticosteroids may be associated with side effects such as adrenal suppression, growth retardation, and osteoporosis. 4 .

Differences between Studies

These studies have shown different results regarding the frequency and severity of side effects of inhaled corticosteroids. 4 . This may be due to factors such as the type and dose of steroid used in the study, the age and health status of the children studied.

Precautions for Real-Life Application

Inhaled corticosteroids are effective medications for treating asthma. However, it is important to be aware that the use of inhaled corticosteroids can cause side effects such as adrenal suppression, growth retardation, and osteoporosis. 4 . If you are prescribed inhaled corticosteroids, it is important to follow your doctor's instructions and consult with your doctor about any side effects.

Limitations of Current Research

There is still a lack of research on the long-term side effects of inhaled corticosteroids. 7 . Further research is needed to gain a deeper understanding of long-term side effects.

Future Research Directions

Future research directions include studies to gain a deeper understanding of the long-term side effects of inhaled corticosteroids, studies to improve the safety and effectiveness of inhaled corticosteroids, and studies to develop alternative therapies for inhaled corticosteroids.

Conclusion

Inhaled corticosteroids are effective medications for treating asthma, but long-term use can cause side effects. 4 . If you are prescribed inhaled corticosteroids, it is important to follow your doctor's instructions and consult with your doctor about any side effects. There is still a lack of research on the long-term side effects of inhaled corticosteroids. 7 . Further research is needed to gain a deeper understanding of long-term side effects.

Literature analysis of 8 papers
Positive Content
7
Neutral Content
0
Negative Content
1
Article Type
7
1
1
1
8
1.

[Inhaled corticotherapy sparing effect by sodium nedocromil in moderate to severe asthma].

Author: MurcianoD, BraunsteinG, MontagutA, ParienteR

Asthma improvement
Steroid sparing effect

Nedocromil sodium was effective in improving moderate to severe asthma in addition to inhaled steroids and had some steroid-sparing effect in patients treated with high-dose inhaled steroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

2.

Neuropsychological and behavioral changes in asthmatic children treated with beclomethasone dipropionate versus theophylline.

Author: BenderB G, IkléD N, DuHamelT, TinkelmanD

Psychological side effects

The relative psychological side effects of theophylline and beclomethasone in asthmatic children need further investigation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Fluticasone propionate powder: oral corticosteroid-sparing effect and improved lung function and quality of life in patients with severe chronic asthma.

Author: NelsonH S, BusseW W, deBoisblancB P, BergerW E, NoonanM J, WebbD R, WolfordJ P, MahajanP S, HamedaniA G, ShahT, HardingS M

Asthma-specific quality of life
Improved lung function
Prednisone withdrawal
Topical effects

Fluticasone propionate powder (500 or 1000 microg twice daily) effectively improved lung function, adrenal function, and asthma-specific quality of life in patients with severe chronic asthma previously treated with oral prednisone while allowing most patients to be weaned off oral corticosteroid therapy. In a study of 111 patients with severe chronic asthma, oral prednisone was eliminated by 75% and 89% of patients in the twice daily 500 and 1000 microg fluticasone propionate groups, respectively, versus 9% of the placebo group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The effectiveness of high-dose inhaled budesonide therapy in the treatment of acute asthma exacerbations in children.

Author: NuhoğluY, BahçecilerN N, BarlanI B, Müjdat BaşaranM

Effective treatment of asthma
Corticosteroid-induced side effects

Guidelines recommend using corticosteroids to treat severe asthma attacks that don’t improve within 24-36 hours of home treatment. While this treatment is unlikely to cause serious problems for infrequent asthma attacks, frequent use can lead to side effects such as adrenal suppression, growth delays, and bone thinning.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Inhaled beclomethasone dipropionate improves acoustic measures of voice in patients with asthma.

Author: BalterM S, AdamsS G, ChapmanK R

Improves voice

Inhaled beclomethasone dipropionate (BDP) improves specific acoustic measures of voice in patients with inadequately controlled asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma.

Author: SzeflerStanley, RohatagiShashank, WilliamsJames, LloydMark, KunduSudeep, BanerjiDonald

No adrenal suppression
Reduces airway inflammation

This study found that treatment with moderate and high doses of ciclesonide does not result in hypothalamic-pituitary-adrenal-axis suppression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Nedocromil sodium for chronic asthma in children.

Author: SridharA V, McKeanM

Asthma treatment
Long-term side effects

This study highlights the need for further research on the long-term side effects of inhaled corticosteroids in treating chronic asthma in children, emphasizing the importance of long-term safety monitoring for this commonly used medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Similar efficacy of ciclesonide versus prednisolone to treat asthma worsening after steroid tapering.

Author: van den BergeM, ArshadS H, IndP W, MagnussenH, HamelmannE, KanniessF, PostmaD S

Improved asthma control
Rapid onset of action
Reduced cortisol suppression
None reported

Inhaled ciclesonide (800mug twice daily) was as effective as oral prednisolone (40mg once daily) in regaining asthma control in patients with asthma worsening, with a more rapid onset and smaller effect on cortisol suppression, suggesting a better safety profile.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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