Effects of atezolizumab injection: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Major Research Findings

Atenolol, a beta-1-adrenergic receptor blocker, has been shown to be an effective antihypertensive agent in several studies. 10 demonstrated that atenolol significantly reduced blood pressure in hypertensive patients compared to placebo, while 7 found that atenolol effectively lowered blood pressure without significantly affecting body weight or plasma renin activity. 9 also indicated that atenolol has a good safety profile and is well-tolerated by most patients.

Atenolol has also been shown to be effective in the treatment of angina pectoris. 3 demonstrated that atenolol significantly improved exercise tolerance and reduced the frequency of angina attacks in patients with stable angina pectoris. 5 also found that atenolol reduced the need for nitroglycerin in patients with angina, suggesting its effectiveness in reducing chest pain.

Benefits and Risks

Benefits Summary

Atenolol has demonstrated significant benefits in managing hypertension and angina pectoris. It effectively lowers blood pressure, improves exercise tolerance in angina patients, and reduces the frequency of angina attacks. In addition, it is well-tolerated by most patients, with minimal side effects reported in various studies. 10 , 7 , 3 , 5 , 9

Risk Summary

While atenolol is generally considered safe, certain risks are associated with its use. 1 found that atenolol can impair ventilatory function in patients with asthma. 16 also reported side effects such as bradycardia and dyspnea in a few patients. Additionally, 20 highlighted potential differences in its effect compared to other beta-blockers like metoprolol, suggesting a need for further research to fully understand its impact on cardiovascular stress reactions.

Comparison Across Studies

Commonalities

Across multiple studies, atenolol has consistently shown its effectiveness in lowering blood pressure and improving exercise tolerance in patients with angina pectoris. 10 , 7 , 3 , 5

Differences

Different studies have highlighted specific risks associated with atenolol, such as its potential impact on respiratory function in asthma patients and the possibility of side effects like bradycardia and dyspnea. 1 , 16 . Furthermore, comparisons with other beta-blockers have suggested potential differences in its effectiveness and side effect profiles. 20

Consistency and Contradictions in Results

The research findings consistently indicate that atenolol is an effective antihypertensive agent. However, some contradictions exist regarding its potential adverse effects, particularly in patients with specific conditions like asthma. Further research is necessary to fully understand the individual risks and benefits of atenolol across different patient populations.

Considerations for Real-World Application

Atenolol is a valuable medication for treating hypertension and angina pectoris. However, patients should be aware of potential side effects and discuss their medical history with their doctor to determine if atenolol is an appropriate treatment option. It is essential to follow a doctor's instructions regarding dosage and to monitor for any adverse reactions. 1 , 16 , 20

Limitations of Current Research

While several studies have investigated atenolol, more research is needed to comprehensively understand its long-term effects, its interactions with other medications, and its impact on specific patient populations. 1 , 16 , 20

Future Research Directions

Future research should focus on exploring the long-term effects of atenolol, investigating its interaction with other medications, and developing strategies to mitigate potential side effects. Further studies are also needed to understand its effectiveness and safety in specific patient populations, such as those with asthma or other cardiovascular conditions. 1 , 16 , 20

Conclusion

Atenolol is a valuable medication for managing hypertension and angina pectoris. While it has demonstrated significant effectiveness, it is crucial to be aware of its potential side effects and to consult with a doctor to determine if it is the appropriate treatment option. Ongoing research is essential to further understand its benefits, risks, and potential for improvement. 10 , 7 , 3 , 5 , 9 , 1 , 16 , 20

Literature analysis of 20 papers
Positive Content
18
Neutral Content
0
Negative Content
2
Article Type
20
0
0
0
20
1.

Effect of atenolol on ventilatory and cardiac function in asthma.

Author: VilsvikJ S, SchaanningJ

Cardioselectivity
Impaired ventilatory function

Atenolol, a cardioselective beta-blocker, was compared to practolol in 12 patients with asthma. Both drugs impaired ventilatory function, but atenolol had a significantly smaller effect. Atenolol did not interfere with bronchodilation induced by isoprenaline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

The effects of atenolol (tenormin) and methyldopa on simple tests of central nervous function.

Author: BaylissP F, DuncanS M

Blood pressure reduction
Drowsiness
Sedation

Atenolol, a beta-blocker, produced no effect on reaction time, critical flicker frequency, or subjective feelings in healthy volunteers, unlike methyldopa which caused significant prolongation of reaction time and drowsiness. Atenolol significantly reduced blood pressure and pulse rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Atenolol in the treatment of angina pectoris.

Author: ErikssenJ, OsvikK, DedichenJ

Angina treatment
Improved exercise performance
Asthenia
Leg fatigue

Atenolol, a beta-blocker, significantly reduced heart rate and blood pressure at rest and during exercise in 19 patients with stable angina pectoris. Higher doses (100 mg) did not significantly improve physical performance compared to lower doses (50 mg). Sixteen patients had better bicycle exercise performance on atenolol than on placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Atenolol and three nonselective beta-blockers in hypertension.

Author: Waal-ManningH J

Cardioselectivity
Lower diastolic pressure
Muscle cramps
Vivid dreams

Atenolol, a cardioselective beta-blocker, was compared to noncardioselective beta-blockers in treating hypertension. Atenolol was found to be as effective as noncardioselective beta-blockers in lowering blood pressure, with lower serum creatinine levels. While there were no serious side effects, some patients experienced vivid dreams or muscle cramps.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Atenolol once daily in angina.

Author: MäkynenP, KarhumäkiL, SeppänenS

Increased exercise tolerance
Reduced angina attacks
Heart enlargement

Atenolol (50 or 100 mg daily) was effective in reducing angina attacks and nitroglycerin consumption. Higher dose of atenolol showed stronger effects on rate-pressure products and slight heart volume enlargement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Controlled study of atenolol in treatment of hypertension.

Author: HanssonL, AbergH, KarlbergB E, WesterlundA

Antihypertensive effect
Clinically relevant
Irrelevant side effects

Atenolol, a beta-1-receptor blocking agent, significantly reduced blood pressure in patients with essential hypertension. The optimal daily dose was 200 mg. There were no significant differences in side effects between the placebo and atenolol groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[Efficacy and tolerability of a cardioselective beta-blocking drug (atenolol) in the treatment of essential hypertension. A double blind study (author's transl)].

Author: RengoF, TrimarcoB, PetrettaM, FerraraN, BonaduceD, ChiarielloM, CondorelliM

Blood pressure reduction

Atenolol, a new beta 1 receptor blocking agent, was found to be effective in reducing blood pressure in patients with mild to moderately severe essential hypertension. Atenolol significantly reduced both systolic and diastolic blood pressure at rest and during exercise. No significant side effects were observed during the study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Italian

8.

Atenolol administered once daily in primary hypertension. Effects on blood pressure in relation to pre-treatment plasma renin activity.

Author: NilssonO R, KarlbergB E, OhlssonO, ThulinT, TolagenK

Antihypertensive effect
Few side effects

Atenolol effectively reduced blood pressure in 37 patients with primary hypertension without significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Clinical evaluation of atenolol in hypertension.

Author: HanssonL, KarlbergB E, AbergH, WesterlundA, HenningsenN C, JamesonS

Good tolerance
Reduced blood pressure
Respiratory issues

Atenolol, a beta-adrenoreceptor-blocking agent, effectively reduced blood pressure in patients with essential hypertension. The optimal dose was 200 mg daily. Atenolol was well-tolerated, but it could worsen ventilatory function in patients with obstructive airways disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Atenolol and bendrofluazide in hypertension.

Author: PetrieJ C, GallowayD B, WebsterJ, SimpsonW T, LewisJ A

Hypertension treatment
Well-tolerated
Thiazide weight gain

Atenolol, a new beta-1-adrenergic receptor blocking agent, was found to be an effective and well-tolerated hypotensive agent in patients with hypertension. Atenolol significantly reduced blood pressure levels, and the effect was comparable to propranolol in animals. The combination of atenolol and bendrofluazide further lowered blood pressure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Effect of partial agonist activity on the side effects of beta-blockade in patients with chronic stable angina.

Author: ChambersJ, OngM L, AkhrasF, AdamG, JacksonG

Angina treatment
Side effects

Epanolol, a beta 1-partial agonist, is as effective as atenolol for chronic stable angina and may improve the side effect profile in some patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Aims of combination therapy--improved quality of life or better blood pressure control?

Author: MacleanD

Increased antihypertensive efficacy
Reduced side effects
Excessive blood pressure drop
Heart failure risk

Combining nifedipine and atenolol may provide additional antihypertensive benefit but can also increase the risk of adverse effects such as excessive blood pressure drops and heart failure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Circulatory effects of intravenous and oral atenolol in acute myocardial infarction.

Author: MidtbøK, SilkeB, VermaS P, ReynoldsG W, HafizullahM, TaylorS H

Heart rate reduction

Atenolol, a beta-blocker, was found to be hemodynamically safe in patients with acute myocardial infarction. The peak hemodynamic effect was similar and independent of the dosage or route of administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

A comparison of once and twice daily atenolol for angina pectoris.

Author: BoyleR M, BrayC L, NaqviN, CroxsonR S, CruickshankJ M

Angina pectoris treatment

Eleven patients with stable angina pectoris were studied with four doses of atenolol, showing improvement in exercise tolerance and duration before onset of angina. A total daily dose of 200 mg reduced maximal heart rate but did not offer additional benefits compared to lower doses. The largest increase in exercise tolerance was observed with 50 mg once daily. Atenolol was effective as an anti-anginal agent when given once daily, with no major differences between the studied doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Central effects of beta-adrenoceptor antagonists.

Author: SalemS A, McDevittD G

None reported
Prolonged reaction time
Reduced cognitive function

Atenolol was given to 6 healthy men. It prolonged reaction time and decreased performance on cognitive tests. These effects were dose-related.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Antihypertensive effect of atenolol (100 mg once a day) and methyldopa (250 mg thrice a day). A double-blind cross-over multicentre study.

Author: KristensenB O, BrønsM, ChristensenC K, GedayE, JacobsenF K, JensenS N, LindeN C

Reduced blood pressure
Superior to methyldopa
Bradycardia
Dyspnoea
Side effects

Atenolol was more effective than methyldopa in treating hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

A comparison of antihypertensive effects between two formulations of atenolol: tenolol and tenormin.

Author: ChiangH T, HouZ Y, LeeD K, WuT L, ChenC Y

Hypertension treatment

The generic formulation of atenolol (Tenolol) had comparable antihypertensive effects to the original formulation (Tenormin).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Prazosin GITS vs atenolol in patients with hypertension and normal lipid profile: a randomized, controlled multicenter study. Hyderabad Hypertension Study Group.

Author: JoglekarS J, JagusteV, NanivadekarA S

Hypertension treatment
Lipid lowering

Prazosin GITS and atenolol showed comparable efficacy and tolerability in controlling hypertension in patients with a normal lipid profile. A randomized, controlled study involving 78 patients found that both drugs effectively lowered blood pressure and had a similar adverse event profile. However, prazosin GITS had a favorable effect on serum lipid levels, while atenolol did not.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Atenolol and eprosartan: differential effects on central blood pressure and aortic pulse wave velocity.

Author: DhakamZahid, McEnieryCarmel M, Yasmin, CockcroftJohn R, BrownMorris J, WilkinsonIan B

Hypertension treatment

This study compares the hemodynamic effects of atenolol and eprosartan in older individuals with hypertension.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease.

Author: GullestadLars, PernowJohn, BjuröThorvald, AabergeLars, SkårdalRita, KjekshusElin, HøglundLena, MellgårdAse Jolin, WahlquistInger, AbladBengt

Cardiovascular stress

Metoprolol and atenolol, two beta-blockers, showed different responses to a Y1 antagonist in patients with coronary artery disease. The antagonist reduced systolic blood pressure rise during exercise in patients taking atenolol but not metoprolol. Additionally, metoprolol patients had higher respiratory sinus arrhythmia, suggesting greater vagal activation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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