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The effects of atenolol (tenormin) and methyldopa on simple tests of central nervous function.

Author: BaylissP F, DuncanS M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Atenolol, a beta-blocker, produced no effect on reaction time, critical flicker frequency, or subjective feelings, while methyldopa produced a statistically significant prolongation of reaction time and increase in subjective drowsiness.
Paper Details　
Original Abstract of the Article :
Two identical studies, one comparing the effect of single doses of a new beta-adrenoceptor blocker, atenolol (Tenormin) (50 mg and 100 mg) and placebo, and the other comparing the effect of single doses of methyldopa (250 mg and 500 mg) and placebo, in healthy volunteers, were carried out. 2 In both...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2125.1975.tb00571.x

データ提供：米国国立医学図書館（NLM）

Atenolol vs. Methyldopa: A Tale of Two Deserts

Navigating the world of medications can sometimes feel like exploring different deserts, each with its own unique landscape and challenges. This study compares two drugs, atenolol (a beta-blocker) and methyldopa (an alpha-2 agonist), to see how they affect brain function. Researchers recruited healthy volunteers and tested their reaction times, critical flicker frequency, and subjective feelings of drowsiness after administering single doses of each drug.

The researchers found that atenolol had no significant effect on brain function, while methyldopa caused a significant increase in reaction time and subjective drowsiness. It's like comparing a desert road where you can drive smoothly without obstacles, to a winding desert path where you encounter sand dunes and get lost easily.

Atenolol: A Smoother Journey Through the Desert of Brain Function

These findings suggest that atenolol is less likely to cause sedation or drowsiness, making it a potentially safer option for those concerned about these side effects.

Navigating the Desert of Medication

It's important to remember that everyone responds to medication differently. It's crucial to work with a healthcare professional to find the medication that's right for you and to monitor for potential side effects. Some medications might cause drowsiness, making it difficult to drive or operate machinery. It's always a good idea to follow your doctor's instructions and to be aware of the potential side effects of any medication you take.

Dr.Camel's Conclusion

This study highlights the importance of understanding the potential side effects of medications. Atenolol appears to be a smoother journey through the desert of brain function, but it's essential to consult with a healthcare professional to determine the best approach for your individual needs.

Date :
  1. Date Completed 1976-12-30
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

9954

DOI: Digital Object Identifier

10.1111/j.1365-2125.1975.tb00571.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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