Side Effects of azelastine ophthalmic: A Synthesis of Findings from 6 Studies

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Original Abstract of the Article

Main research findings

Azelastine eye drops have been shown to be effective and well tolerated for the treatment of seasonal allergic conjunctivitis. A double-blind, randomized, placebo-controlled study 4 found that 0.05% azelastine eye drops were significantly more effective than placebo. Additionally, a study 5 found that azelastine eye drops were either equivalent to or more effective than mitomycin C eye drops in the treatment of allergic conjunctivitis.

Reasons for side effects

Side effects of azelastine eye drops may result from the drug's direct action on the surface of the eye and surrounding tissues. Azelastine eye drops can also be absorbed into the eye and circulate throughout the body, which may lead to systemic side effects.

Common side effects

Eye irritation

Azelastine eye drops can cause eye irritation, burning, and itching. 4 reported that 14–20% of patients who received azelastine eye drops reported mild and transient irritation. Also, a study 5 reported eye irritation in the azelastine eye drop group.

Altered taste

Azelastine eye drops may have a bitter or unpleasant taste. 4 reported that 14–20% of patients who received azelastine eye drops reported a bitter or unpleasant taste.

Measures for side effects

Eye irritation

If eye irritation is severe, stop using the eye drops and consult your doctor.

Altered taste

If you are concerned about changes in taste, you can use eye drops after meals or rinse your mouth after using eye drops.

Comparison between studies

Commonalities of studies

All three studies showed that azelastine eye drops were effective in treating allergic conjunctivitis. All three studies also showed that azelastine eye drops were safe.

Differences between studies

The study 4 compared two concentrations of azelastine eye drops, 0.025% and 0.05%. The study found that 0.05% was more effective. On the other hand, the study 5 found that azelastine eye drops were equivalent to or more effective than mitomycin C eye drops. Also, the study 5 reported that mitomycin C eye drops can cause corneal abnormalities as a side effect, but this was not reported for azelastine eye drops.

Precautions for application in real life

Azelastine eye drops are effective in treating allergic conjunctivitis, but they can cause side effects. Therefore, be sure to consult your doctor before using azelastine eye drops. If you experience side effects such as eye irritation, altered taste, or other side effects while using azelastine eye drops, discontinue use and consult your doctor.

Limitations of current research

There is not yet sufficient data on the long-term safety of azelastine eye drops. There is also not enough data on the safety of azelastine eye drops during pregnancy and breastfeeding.

Future research directions

Further research is needed on the long-term safety of azelastine eye drops, as well as on its safety during pregnancy and breastfeeding.

Conclusion

Azelastine eye drops have been shown to be effective and well tolerated for the treatment of seasonal allergic conjunctivitis. Studies 4 , 5 found that azelastine eye drops were equivalent to or more effective than placebo and mitomycin C eye drops. However, it is important to note that side effects may occur, so be sure to consult your doctor before using azelastine eye drops.

Literature analysis of 6 papers
Positive Content
6
Neutral Content
0
Negative Content
0
Article Type
5
0
0
1
6
1.

The effects of atenolol (tenormin) and methyldopa on simple tests of central nervous function.

Author: BaylissP F, DuncanS M

Blood pressure reduction
Drowsiness
Sedation

Atenolol, a beta-blocker, produced no effect on reaction time, critical flicker frequency, or subjective feelings in healthy volunteers, unlike methyldopa which caused significant prolongation of reaction time and drowsiness. Atenolol significantly reduced blood pressure and pulse rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effect of partial agonist activity on the side effects of beta-blockade in patients with chronic stable angina.

Author: ChambersJ, OngM L, AkhrasF, AdamG, JacksonG

Angina treatment
Side effects

Epanolol, a beta 1-partial agonist, is as effective as atenolol for chronic stable angina and may improve the side effect profile in some patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Aims of combination therapy--improved quality of life or better blood pressure control?

Author: MacleanD

Increased antihypertensive efficacy
Reduced side effects
Excessive blood pressure drop
Heart failure risk

Combining nifedipine and atenolol may provide additional antihypertensive benefit but can also increase the risk of adverse effects such as excessive blood pressure drops and heart failure.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Double-blind, randomised, placebo-controlled study of two concentrations of azelastine eye drops in seasonal allergic conjunctivitis or rhinoconjunctivitis.

Author: LenhardG, Mivsek-MusicE, Perrin-FayolleM, ObtulowiczK, SecchiA

Effective treatment
Well tolerated
Mild irritation
Unpleasant taste

Azelastine eye drops were effective and well tolerated at a concentration of 0.05% for the treatment of seasonal allergic conjunctivitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Efficacy and safety of topical azelastine compared with topical mitomycin C in patients with allergic conjunctivitis.

Author: SodhiPunita Kumari, PandeyRavindra M, RatanSimmi K

Allergic conjunctivitis treatment
Conjunctival hyperemia
Episcleritis
Irritation

Topical mitomycin C (MMC) was more effective than topical azelastine in treating allergic conjunctivitis, both in terms of symptom relief and resolution of signs. MMC was well tolerated in low doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Antihistamines: topical vs oral administration.

Author: DaviesR J, BagnallA C, McCabeR N, CalderonM A, WangJ H

Improved safety
Reduced ICAM-1 expression
Reduced inflammatory cell influx
Reduced nasal symptoms
Relieves ocular itch
Severe side-effects

The study explored the additional pharmacological activities of antihistamines beyond histamine blockage in the treatment of allergic rhinitis. In vitro studies demonstrated that high concentrations of second-generation antihistamines can block inflammatory mediator release and reduce ICAM-1 expression. In vivo studies showed a reduction in nasal symptoms and inflammatory cell influx with both oral and intranasal antihistamines. Clinical trials suggest that topical levocabastine and azelastine may be more effective than oral terfenadine in relieving ocular itch and nasal symptoms.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
CongressA conference or meeting where experts in a specific field gather. It provides opportunities for presentations, discussions, and networking, and serves as a place to share expertise and learn about the latest trends in the industry.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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