Effects of benzoyl peroxide topical: A Synthesis of Findings from 9 Studies

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Original Abstract of the Article

Key Research Findings

Benzoyl peroxide topical is a commonly used treatment for acne. 1 A systematic review of randomized controlled trials showed that benzoyl peroxide topical treatment was significantly more effective than vehicle treatment in reducing the total number of acne lesions, inflammatory lesions, and non-inflammatory lesions. 1 However, the effectiveness of benzoyl peroxide topical may be influenced by clinical trial design, implementation, and vehicle effects. 1 This effectiveness may vary depending on the severity of acne and skin type. 5 A subgroup analysis of black subjects with moderate acne showed that adapalene-benzoyl peroxide topical gel was safe and effective. 5 A meta-analysis of subjects with Fitzpatrick skin types I to VI found no statistically significant difference in dryness, scaling, and stinging/burning between the two groups. 6 However, erythema assessments were statistically different, with subjects with Fitzpatrick skin types IV to VI rated as having "none" more often. 6 This could be due to the difficulty in visualizing erythema in darker skin types. 6 A study on tretinoin gel microsphere 0.1% demonstrated its stability and resistance to photodegradation, even when combined with erythromycin-benzoyl peroxide topical gel. 4

Benefits and Risks

Benefit Summary

Benzoyl peroxide topical is effective for acne treatment and has been shown to reduce the total number of acne lesions, inflammatory lesions, and non-inflammatory lesions. 1 Adapalene-benzoyl peroxide topical gel is safe and effective for moderate acne in black subjects. 5 Adapalene-benzoyl peroxide topical gel is safe and effective for various skin types, including Fitzpatrick skin types IV to VI, and no statistically significant differences in dryness, scaling, and stinging/burning were observed between the groups. 6

Risk Summary

Benzoyl peroxide topical can cause side effects such as dryness, redness, itching, and irritation. 2 Benzoyl peroxide can degrade in sunlight, so it is recommended to use sunscreen. 4

Comparison Between Studies

Commonalities in Studies

These studies used randomized controlled trials to evaluate the effectiveness of benzoyl peroxide topical for acne treatment. 1 They also reported on the potential side effects of benzoyl peroxide topical. 2

Differences in Studies

These studies differed in the severity of acne, skin types, benzoyl peroxide concentration, and concomitant medications. 5 , 6 They also differed in study design and implementation methods. 1

Consistency and Contradictions in Results

These studies consistently showed that benzoyl peroxide topical is effective for acne treatment. 1 However, the effectiveness of benzoyl peroxide topical may be influenced by clinical trial design, implementation, and vehicle effects. 1 The effectiveness may also vary depending on the severity of acne and skin type. 5

Practical Applications and Considerations

Benzoyl peroxide topical is an effective treatment for acne, but it also carries the risk of side effects. 2 Therefore, it is important to consult a dermatologist before using benzoyl peroxide topical and to follow proper usage instructions. 2 It is also recommended to use sunscreen when using benzoyl peroxide topical. 4

Limitations of Current Research

These studies were conducted with limited sample sizes, durations, and conditions to evaluate the effectiveness and safety of benzoyl peroxide topical. 1 , 5 Therefore, the results of these studies may not be applicable to other populations or conditions. 1 , 5

Future Research Directions

It is necessary to evaluate the effectiveness and safety of benzoyl peroxide topical in a broader range of populations, conditions, and durations. 1 , 5 It is also necessary to evaluate the effectiveness and side effects of benzoyl peroxide topical across various acne severities, skin types, concomitant medications, and drug concentrations. 5

Conclusion

Benzoyl peroxide topical is an effective treatment for acne. 1 However, it is important to consult a dermatologist before using benzoyl peroxide topical and to follow proper usage instructions. 2 It is recommended to use sunscreen when using benzoyl peroxide topical. 4 There are various treatment options for acne, so it is crucial to consult a dermatologist to find the right treatment for you. 3

Literature analysis of 9 papers
Positive Content
9
Neutral Content
0
Negative Content
0
Article Type
0
1
2
4
9
1.

Evaluating clinical trial design: systematic review of randomized vehicle-controlled trials for determining efficacy of benzoyl peroxide topical therapy for acne.

Author: LamelSonia A, SivamaniRaja K, RahvarMaral, MaibachHoward I

Acne treatment

Topical benzoyl peroxide is an effective treatment for acne, but its efficacy may be affected by study design, implementation, and vehicle effects. Including a 'no treatment' group in clinical trials could help determine accurate treatment efficacies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Side effects of common acne treatments.

Author: TripathiShivani V, GustafsonCheryl J, HuangKaren E, FeldmanSteven R

Acne treatment
Diverse treatment options
Potential side effects
Side effects

Many treatments exist for acne, including topical medications, oral antibiotics, hormonal therapy, isotretinoin, and light/laser therapies. While these treatments have benefits, it's crucial for healthcare providers to be aware of both common and serious side effects to ensure safe use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Emerging drugs for acne.

Author: JamesKirk A, BurkhartCraig N, MorrellDean S

Acne treatment
Improved mental health
Reduced scarring
Antibiotic resistance
Isotretinoin side effects
Pregnancy risk

This article reviews emerging treatments of acne, including topical picolinic acid, topical antibiotic dapsone, systemic zinc salts, oral antibiotic lymecycline, new formulations of and synergistic combinations of benzoyl peroxide, photodynamic therapy with topical photosensitizers and potential acne vaccines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

The stability of tretinoin in tretinoin gel microsphere 0.1%.

Author: NyiradyJudit, LucasCarmelle, YusufMohammed, MignonePamela, WisniewskiStephen

Acne Treatment
Photostability

Topical tretinoin is a drug used to treat acne. It is more effective and less likely to degrade when it is formulated as a microsphere.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

A subgroup analysis to evaluate the efficacy and safety of adapalene-benzoyl peroxide topical gel in black subjects with moderate acne.

Author: AlexisAndrew F, JohnsonLori A, KerroucheNabil, CallenderValerie D

Acne treatment
Safe for black skin
PIH

This study pooled data from three multicenter, randomized, double-blind, placebo-controlled studies involving 3,855 subjects to analyze the safety and efficacy of adapalene benzoyl peroxide topical gel in the treatment of acne for all skin types, specifically in black subjects. The results demonstrated that adapalene-BPO was safe and effective for acne treatment in black skin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Evidence-based recommendations for the diagnosis and treatment of pediatric acne.

Author: EichenfieldLawrence F, KrakowskiAndrew C, PiggottCaroline, Del RossoJames, BaldwinHilary, FriedlanderSheila Fallon, LevyMoise, LuckyAnne, ManciniAnthony J, OrlowSeth J, YanAlbert C, VauxKeith K, WebsterGuy, ZaengleinAndrea L, ThiboutotDiane M,

Acne treatment

This report provides recommendations for the diagnosis and management of pediatric acne, based on a review of current guidelines and expert consensus. The recommendations address the unique presentation and treatment needs of children and adolescents with acne.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Endocrine disorders and hormonal therapy for adolescent acne.

Author: NguyenHenry L, TollefsonMegha M

Treat acne

This review examines hormonal therapies for the treatment of acne vulgaris, a global disease with increasing prevalence in adolescents. The focus is on alternative treatment options, considering concerns about antibiotic resistance and stewardship.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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