Effects of betaxolol ophthalmic: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Major Research Findings

Betaxolol eye drops have been shown to be effective in lowering intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension. 1 8 7 Betaxolol works by suppressing the production of aqueous humor, the fluid that fills the front of the eye. 6 Betaxolol has been shown to be more comfortable for patients than some other eye drops. 1 In addition, betaxolol is a cardioselective beta-blocker, which means it has minimal impact on heart rate and blood pressure. 1 However, betaxolol eye drops have also been linked to skin discoloration. 5 Betaxolol eye drops can also affect blood flow in the eye. 10 9 It's important to note that some studies have found that betaxolol may not be as effective at lowering intraocular pressure as other eye drops. 2

Benefits and Risks

Benefit Summary

Betaxolol eye drops have been shown to be effective in lowering intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension. 1 8 7 Betaxolol works by suppressing the production of aqueous humor, the fluid that fills the front of the eye. 6 Betaxolol has been shown to be more comfortable for patients than some other eye drops. 1

Risk Summary

Betaxolol eye drops have been linked to skin discoloration. 5 Betaxolol eye drops can also affect blood flow in the eye. 10 9 It's important to note that some studies have found that betaxolol may not be as effective at lowering intraocular pressure as other eye drops. 2

Comparison Between Studies

Similarities

Several studies have shown that betaxolol eye drops are effective in lowering intraocular pressure. 1 8 7 In addition, betaxolol is a cardioselective beta-blocker, which means it has minimal impact on heart rate and blood pressure. 1

Differences

Different studies have produced differing results regarding the effectiveness and side effects of betaxolol eye drops. For example, while some studies suggest that betaxolol eye drops are more comfortable than other eye drops, others have shown that it may be less effective at lowering intraocular pressure. 1 2 Also, it's important to note that betaxolol eye drops have been linked to skin discoloration. 5

Consistency and Contradictions of Results

Multiple studies have demonstrated the effectiveness of betaxolol eye drops in lowering intraocular pressure. 1 8 7 However, research findings regarding the effectiveness and side effects of betaxolol eye drops can vary. 1 2 These discrepancies may be attributed to differences in research methodologies and participant characteristics.

Cautions for Real-Life Applications

Betaxolol eye drops are used to treat primary open-angle glaucoma or ocular hypertension, but they can have side effects such as eye irritation and skin discoloration. 1 5 Therefore, it's crucial to follow your doctor's instructions carefully and seek immediate medical attention if you experience any adverse effects.

Limitations of Current Research

Research on betaxolol eye drops is still insufficient. More research is needed, especially regarding the long-term effectiveness and safety of betaxolol eye drops.

Future Research Directions

Further research is needed to evaluate the long-term effectiveness and safety of betaxolol eye drops, as well as comparative studies between betaxolol and other eye drops.

Conclusion

Betaxolol eye drops can be effective in lowering intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension. 1 8 7 However, it's important to be aware of the potential side effects, such as skin discoloration and impact on blood flow in the eye. 5 10 9 When using betaxolol eye drops, carefully follow your doctor's instructions and report any adverse effects immediately.

Literature analysis of 10 papers
Positive Content
7
Neutral Content
0
Negative Content
3
Article Type
6
0
0
0
10
1.

A double-masked three-month comparison between 0.25% betaxolol suspension and 0.5% betaxolol ophthalmic solution.

Author: WeinrebR N, CaldwellD R, GoodeS M, HorwitzB L, LaibovitzR, ShraderC E, StewartR H, WilliamsA T

Lower intraocular pressure
Reduced ocular discomfort

Beta-xolol ophthalmic solution was found to be effective in reducing intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension. However, 0.25% betaxolol suspension was found to be more comfortable for patients to use, as it resulted in significantly less ocular discomfort.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Changing therapy from timolol to betaxolol. Effect on intraocular pressure in selected patients with glaucoma. Timolol-Betaxolol Study Group.

Author: VogelR, TippingR, KulagaS F, ClineschmidtC M

Increased intraocular pressure
Ocular side effects

This study compared the effects of timolol and betaxolol, both beta-blocker eye drops, in 353 patients with controlled intraocular pressure. Patients switched to betaxolol experienced a significant increase in both ocular side effects (burning/stinging and tearing) and intraocular pressure compared to those who continued on timolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

A double-masked three-month comparison between 0.25% betaxolol suspension and 0.5% betaxolol ophthalmic solution.

Author: WeinrebR N, CaldwellD R, GoodeS M, HorwitzB L, LaibovitzR, ShraderC E, StewartR H, WilliamsA T

Lower intraocular pressure
Reduced ocular discomfort

Beta-xolol ophthalmic solution was found to be effective in reducing intraocular pressure in patients with primary open-angle glaucoma or ocular hypertension. However, 0.25% betaxolol suspension was found to be more comfortable for patients to use, as it resulted in significantly less ocular discomfort.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Changing therapy from timolol to betaxolol. Effect on intraocular pressure in selected patients with glaucoma. Timolol-Betaxolol Study Group.

Author: VogelR, TippingR, KulagaS F, ClineschmidtC M

Increased intraocular pressure
Ocular side effects

This study compared the effects of timolol and betaxolol, both beta-blocker eye drops, in 353 patients with controlled intraocular pressure. Patients switched to betaxolol experienced a significant increase in both ocular side effects (burning/stinging and tearing) and intraocular pressure compared to those who continued on timolol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Betaxolol-associated hyperpigmentation of the fingers in a patient with unrelated contact dermatitis.

Author: AdamsD R, MarksJ G

skin hyperpigmentation

Betaxolol, an eye drop solution, has been associated with periocular skin hyperpigmentation. This report describes a case of a woman who experienced hyperpigmentation of her fingers after taking oral betaxolol.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

The mechanism of betaxolol, a new ocular hypotensive agent.

Author: ReissG R, BrubakerR F

No pupillary changes
Suppresses aqueous humor flow
No consistent effect on outflow resistance

Betaxolol ophthalmic solution effectively suppresses aqueous humor flow without affecting outflow resistance or causing pupillary changes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Betaxolol hydrochloride ophthalmic suspension 0.25% and timolol gel-forming solution 0.25% and 0.5% in pediatric glaucoma: a randomized clinical trial.

Author: PlagerDavid A, WhitsonJess T, NetlandPeter A, VijayaLingam, SathyanParthasarathy, SoodDevindra, KrishnadasS R, RobinAlan L, GrossRobert D, ScheibSally A, ScottHaydn, DickersonJaime E,

IOP reduction
Eye irritation

Betaxolol ophthalmic suspension 0.25%, TGFS 0.25%, and TGFS 0.5% were well tolerated and produced statistically significant mean reductions in intraocular pressure (IOP) in pediatric glaucoma subjects. Responder rates (> or =15% reduction from baseline) were 38.2%, 45.7%, and 47.2%, respectively.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Use of betaxolol in the reduction of elevated intraocular pressure.

Author: RadiusR L

Reduced IOP
None reported

Betaxolol ophthalmic solution (0.125%) reduced intraocular pressure (IOP) more effectively than a placebo in patients with elevated IOP. Both solutions were well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Short-term effect of beta-adrenoreceptor blocking agents on ocular blood flow.

Author: SatoT, MutoT, IshibashiY, RoyS

Maintained retinal blood flow
Reduced ciliary body blood flow

Beta-blocker betaxolol may be more appropriate for maintenance of retinal blood flow in situations with low perfusion. Decreased CiBF may contribute to reduction in IOP.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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