Side Effects of brompheniramine: A Synthesis of Findings from 11 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of brompheniramine: A Synthesis of Findings from 11 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Main Research Findings

Brompheniramine is effective in treating allergic rhinitis. 11 showed that brompheniramine, combined with phenylpropanolamine, was effective in children with allergic rhinitis. Brompheniramine was also found to be comparable in effectiveness to mequitazine, but with fewer side effects such as drowsiness. 10

Reasons for Side Effects

Brompheniramine is an antihistamine drug, which blocks the action of histamine, a chemical that is released during allergic reactions. Histamine can cause symptoms like runny nose, sneezing, itchy eyes, and skin rashes. By blocking histamine, brompheniramine helps alleviate these symptoms. However, brompheniramine can also affect the central nervous system, leading to side effects like drowsiness and fatigue. 3 indicated that first-generation H1 receptor antagonists like brompheniramine can impair performance, potentially causing or contributing to aviation accidents.

Common Side Effects

Drowsiness

Brompheniramine can cause side effects like drowsiness. 10 showed that brompheniramine caused more drowsiness compared to mequitazine. In another study, 5 found that brompheniramine was associated with more drowsiness than astemizole.

Dry Mouth

Brompheniramine can also cause dry mouth. 5 found that dry mouth was reported more frequently in patients taking brompheniramine compared to those taking astemizole.

Fatigue

Fatigue is another possible side effect of brompheniramine. 5 indicated that brompheniramine was associated with more fatigue than astemizole.

Countermeasures for Side Effects

Drowsiness

Avoid driving or operating machinery that requires alertness while taking brompheniramine. 3 recommends caution with first-generation H1 receptor antagonists like brompheniramine due to their potential to affect driving and operating machinery.

Dry Mouth

Drink plenty of water if you experience dry mouth.

Fatigue

Rest when you feel fatigued.

Comparison between Studies

Commonalities between Studies

Multiple studies suggest that brompheniramine is effective for treating allergic rhinitis. Multiple studies have also found that brompheniramine can cause side effects such as drowsiness, dry mouth, and fatigue.

Differences between Studies

Studies comparing brompheniramine to other antihistamines suggest that brompheniramine may cause stronger drowsiness compared to other antihistamines. Some studies have also found that brompheniramine may be less effective compared to other antihistamines.

Notes on Application to Daily Life

While brompheniramine can effectively alleviate allergic rhinitis symptoms, it can also cause drowsiness. Avoid driving or operating machinery that requires alertness while taking brompheniramine. Always consult your doctor before taking brompheniramine, as self-medication can be harmful.

Limitations of Current Research

While multiple studies have demonstrated the effectiveness of brompheniramine, it cannot be concluded that it is safe and effective for everyone. Brompheniramine can have different effects and side effects based on individual constitution. It can also interact with other medications. Always consult your doctor before taking brompheniramine.

Future Research Directions

Research on the long-term effects and safety of brompheniramine is necessary. Further research is also needed to understand the potential for brompheniramine to interact with other medications.

Conclusion

Brompheniramine is an effective medication for treating allergic rhinitis, but it can cause side effects like drowsiness. Follow your doctor's instructions and take brompheniramine carefully.

Literature analysis of 11 papers
Positive Content
8
Neutral Content
1
Negative Content
2
Article Type
4
0
0
2
11
1.

Pediatric Fatalities Associated With Over-the-Counter Cough and Cold Medications.

Author: HalmoLaurie Seidel, WangGeorge Sam, ReynoldsKate M, Delva-ClarkHeather, Rapp-OlssonMalin, BannerWilliam, BondG Randall, KauffmanRalph E, PalmerRobert B, PaulIan M, GreenJody L, DartRichard C

Fatalities

This study describes fatalities associated with exposures to over-the-counter cough and cold medications in children younger than 12 years old.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Safety Profile of Cough and Cold Medication Use in Pediatrics.

Author: GreenJody L, WangGeorge Sam, ReynoldsKate M, BannerWilliam, BondG Randall, KauffmanRalph E, PalmerRobert B, PaulIan M, DartRichard C

Cough and cold relief
Agitation
Ataxia
Hallucinations
Mydriasis
Somnolence
Tachycardia

This study describes the safety profile of cough and cold medications (CCMs) in children <12 years of age from a multisystem surveillance program. The rate of AEs associated with CCMs in children was low. Fatalities occurred even less frequently. No fatality involved a therapeutic dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes.

Author: YasudaS U, YasudaR P

Anticholinergic effects

Anticholinergic effects are thought to contribute to the effectiveness of chlorpheniramine in treating the common cold. This study evaluated the affinities of brompheniramine, chlorpheniramine, and terfenadine, commonly used antihistamines, for human muscarinic cholinergic receptor subtypes. Results showed that all three drugs exhibited similar affinities for the five subtypes, while terfenadine demonstrated subtype selectivity at m3.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Astemizole in combination with pseudoephedrine in the treatment of seasonal allergic rhinitis.

Author: SimolaM, BössI, HolopainenE, MalmbergH, RuoppiP, SeppäJ, SiivonenL, SuonpääJ, PiepponenT

Allergic rhinitis relief
Drowsiness
Dry mouth
Tiredness

The study compared the effectiveness and side effects of once-daily astemizole-D and twice-daily brompheniramine-D in 64 patients with seasonal allergic rhinitis. Both drugs were effective in reducing nasal and eye symptoms. However, astemizole-D was better tolerated than brompheniramine-D, as patients in the brompheniramine-D group experienced more dry mouth, tiredness, and drowsiness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

[Allergy in pregnancy].

Author: Di LorenzoG, MansuetoP, MellusoM, Purello D'AmbrosioF, PutignanoE, Barbagallo SangiorgiG

Safe for pregnancy

The study provides a summary of drug recommendations for allergy treatment during pregnancy. It highlights that no drug is considered completely safe during pregnancy, and recommends various medications with relatively lower risks.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Italian

8.

Safety of therapy for allergic symptoms during pregnancy.

Author: GreenbergerP, PattersonR

Safe pregnancy treatment

A review of literature suggests that most commonly used antihistamines are safe during pregnancy, with the exception of brompheniramine. Bronchodilators ephedrine and theophylline, as well as cromolyn, also appear safe. Corticosteroids appear safe during pregnancy when used as aerosols, and allergic immunotherapy has been found safe. Annual influenza vaccination is recommended for pregnant women with asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Clinical trial with Lunerin mixture and Lunerin mite in children with secretory otitis media.

Author: SaunteC

Improved ear drum appearance and mobility
Improved hearing threshold
Low incidence of side effects
Reduced myringotomies
Reduced observation time

A combination of antihistamine and vasoconstrictor was more effective than placebo in treating secretory otitis media in children. The incidence of side-effects was low.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Comparative trial of two antihistamines, mequitazine and brompheniramine.

Author: BlamoutierJ

Allergy treatment
Mild side effects

Mequitazine and brompheniramine, both antihistamines, were compared for their efficacy and tolerability in treating allergic disorders. Mequitazine was found to be at least as effective as brompheniramine, but with significantly less drowsiness. Few other side effects were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Treatment of children with perennial rhinitis with brompheniraminemaleate and phenylpropanolaminehydrochloride (lunerin mite)

Author: KjellmanM

Allergic rhinitis relief
Negligible side effects

A combined pediatric preparation of brompheniramine maleate and phenylpropanolamine hydrochloride (Lunerin mite) was effective in treating allergic rhinitis in children aged 4-14 years. The drug was well-tolerated, with negligible side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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