Effects of calcitriol topical: A Synthesis of Findings from 9 Studies

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Original Abstract of the Article

Major Research Findings

Captopril, an angiotensin-converting enzyme inhibitor (ACEI), has shown to be effective in lowering blood pressure without increasing heart rate. 8 Studies have indicated that captopril may have a greater effect on the parasympathetic nervous system than the sympathetic nervous system, contributing to its blood pressure lowering effect. 4 , 3 It is noteworthy that captopril has not been shown to impair cognitive function, and there are indications that it might even improve memory. 6 However, in patients with cirrhosis, captopril may have detrimental effects on kidney function, potentially due to a drop in blood pressure. 9 Additionally, captopril has been reported to cause side effects such as coughing and taste disturbances.

Benefits and Risks

Benefits Summary

Captopril is an effective medication for lowering blood pressure and has been shown to be beneficial for hypertensive patients. 8 It does not appear to negatively impact cognitive function, and there is evidence that it could potentially improve memory. 4 , 3 , 6

Risks Summary

In patients with cirrhosis, captopril may have detrimental effects on kidney function. 9 Potential side effects of captopril include coughing and taste disturbances.

Comparison of Studies

Commonalities of Studies

All of these studies consistently demonstrate the effectiveness of captopril in lowering blood pressure.

Differences in Studies

These studies focus on specific aspects of captopril's effects and side effects. For instance, the study in 8 examined the impact of captopril on the parasympathetic nervous system, while the study in 9 investigated the influence of captopril on patients with cirrhosis.

Consistency and Contradictions in Findings

These studies consistently indicate that captopril is an effective medication for treating hypertension. However, the study in 9 suggests the possibility of adverse effects on kidney function in patients with cirrhosis. This discrepancy necessitates further research to clarify.

Practical Implications and Considerations

Captopril is an effective medication for treating hypertension, but it may have detrimental effects on kidney function in certain conditions, such as cirrhosis. 9 It is crucial to follow the advice of a healthcare professional when taking captopril.

Limitations of Current Research

These studies highlight the need for larger, longer-term investigations to gain a more comprehensive understanding of captopril's effects and side effects.

Future Research Directions

Further research is needed to explore the long-term effects of captopril, its impact on specific diseases, and to investigate ways to minimize potential side effects.

Conclusion

Captopril is an effective medication for treating hypertension, but it may have detrimental effects on kidney function in certain conditions. These findings underscore the importance of following the advice of a healthcare professional when taking captopril. Future research is expected to provide further insights into the benefits and risks associated with captopril.

Literature analysis of 9 papers
Positive Content
8
Neutral Content
1
Negative Content
0
Article Type
9
0
0
0
9
1.

Quality of life in hypertensives treated with atenolol or captopril: a double-blind crossover trial.

Author: PalmerA J, FletcherA E, RudgeP J, AndrewsC D, CallaghanT S, BulpittC J

Captopril and atenolol did not significantly differ in their effects on the quality of life of hypertensive patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

[Captopril + hydrochlorothiazide versus captopril + nifedipine in the treatment of arterial hypertension in diabetes mellitus type II].

Author: Souvirón RodríguezA, Martínez MorilloM

Effective treatment
Improved glucose tolerance
Reduced renal insufficiency

Captopril was found to be an effective treatment for hypertension in diabetic patients. It lowered blood pressure without inducing metabolic changes, improving glucose tolerance and slowing the progression of renal insufficiency.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

3.

[Psychotropic effects of captopril? Effect of a short-term treatment on reaction and concentration capabilities and space perception ability].

Author: RüddelH, Napp-ZinnL, SchächingerH, MayH, LangewitzW

No negative effects

Captopril did not have any negative effects on cognitive function in healthy normotensive young men.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

4.

Central effects of the angiotensin-converting enzyme inhibitor, captopril. I. Performance and subjective assessments of mood.

Author: CurrieD, LewisR V, McDevittD G, NicholsonA N, WrightN A

Improved letter cancellation
Improved short-term memory

Captopril does not impair performance or mood in healthy subjects and may be a suitable treatment for hypertensive patients engaged in skilled activity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Captopril: contrasting effects of adding hydrochlorothiazide, propranolol, or nifedipine.

Author: MacGregorG A, MarkanduN D, SmithS J, SagnellaG A

Reduced blood pressure

Captopril is less effective in patients with essential hypertension and low renin and angiotensin levels. Its effectiveness can be increased with sodium restriction, diuretics, and nifedipine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Angiotensin converting enzyme and memory: preclinical and clinical data.

Author: SudilovskyA, TurnbullB, CroogS H, CrookT

Improved cognitive performance
Mental acuity

ACE inhibitors may improve cognitive function beyond their blood pressure lowering effects. Captopril showed better cognitive performance compared to propranolol or methyldopa. Further research suggests that ACE inhibition might reduce AII formation, leading to improved cognitive function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Captopril and opiate antagonism in essential hypertension.

Author: AjayiA A, RubinP C, ReidJ L

Naloxone did not modify the circulatory effects of captopril in patients who had been taking captopril for 2-25 months. This finding suggests that the antihypertensive effects of captopril are not significantly mediated by endogenous opioids in the long term.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Evidence of parasympathetic activity of the angiotensin converting enzyme inhibitor, captopril, in normotensive man.

Author: CampbellB C, SturaniA, ReidJ L

Blood Pressure Reduction

Captopril reduces blood pressure without increasing heart rate. It may have a parasympathetic effect contributing to its haemodynamic profile.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Effects of low-dose captopril on renal hemodynamics and function in patients with cirrhosis of the liver.

Author: GentiliniP, RomanelliR G, La VillaG, MaggioreQ, PesciullesiE, CappelliG, Casini RaggiV, FoschiM, MarraF, PinzaniM

Cirrhosis treatment
Renal dysfunction

Captopril is a drug that can have negative effects on kidney function in patients with cirrhosis and ascites. A study using low doses of captopril found that it did not affect blood pressure, suggesting that it may be a safe option for treating these patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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