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Effects of low-dose captopril on renal hemodynamics and function in patients with cirrhosis of the liver.

Author: CappelliG, Casini RaggiV, FoschiM, GentiliniP, La VillaG, MaggioreQ, MarraF, PesciullesiE, PinzaniM, RomanelliR G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Captopril is a drug that can have negative effects on kidney function in patients with cirrhosis and ascites. A study using low doses of captopril found that it did not affect blood pressure, suggesting that it may be a safe option for treating these patients.
Paper Details　
Original Abstract of the Article :
In cirrhotic patients with ascites, captopril has deleterious effects on renal function, which have been referred to as captopril-induced arterial hypotension. The effects of this drug on renal function in cirrhosis were evaluated using low-dose captopril, thereby avoiding any change in arterial pre...See full text at original site
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引用元：
https://doi.org/10.1016/0016-5085(93)90431-b

データ提供：米国国立医学図書館（NLM）

Captopril: A Careful Approach in Cirrhosis

Cirrhosis, a chronic liver disease, often presents unique challenges for healthcare professionals. This research investigates the effects of low-dose captopril, an angiotensin-converting enzyme (ACE) inhibitor, on renal hemodynamics and function in patients with cirrhosis. The study explores the potential risks and benefits of captopril in this specific patient population, carefully examining the impact on renal function while minimizing any changes in arterial pressure. This research is like a skilled desert guide meticulously navigating a delicate ecosystem, seeking to minimize the risks while maximizing the potential benefits for those living with cirrhosis.

Captopril and Cirrhosis: A Balancing Act

The research suggests that low-dose captopril may be a viable option for managing renal function in patients with cirrhosis, but careful monitoring and individualized dosing are essential. The study findings suggest that the drug can have deleterious effects on renal function in patients with ascites, highlighting the need for caution and close monitoring. This research is a reminder that even well-intended interventions may have unforeseen consequences, underscoring the importance of personalized approaches in healthcare.

Understanding the Risks: A Guide for Decision-Making

This research emphasizes the importance of a cautious approach to using captopril in patients with cirrhosis. The study findings highlight the potential risks associated with the drug, particularly in patients with ascites. It is crucial for healthcare professionals to carefully consider the individual patient's risk profile and to monitor renal function closely when prescribing captopril to patients with cirrhosis. It is like navigating a desert landscape; careful planning, awareness of potential hazards, and constant vigilance are essential for a safe and successful journey.

Dr.Camel's Conclusion

This research provides valuable insights into the complex relationship between captopril and renal function in patients with cirrhosis. It underscores the need for a personalized approach to managing this condition, taking into account the unique needs and risks of each individual. It is a reminder that the desert of healthcare is full of unexpected turns and challenges, requiring careful navigation and a constant quest for knowledge.

Date :
  1. Date Completed 1993-02-26
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

8425702

DOI: Digital Object Identifier

10.1016/0016-5085(93)90431-b

SNS
PICO Info
in preparation
Languages

English

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