Effects of captopril: A Synthesis of Findings from 9 Studies

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Original Abstract of the Article

Major Research Findings

Captopril, an angiotensin-converting enzyme inhibitor (ACE inhibitor) commonly used for treating high blood pressure, has shown potential effects on cognitive function in several studies. 6 reported that hypertensive patients treated with captopril exhibited improved cognitive performance compared to those treated with propranolol or methyldopa. This finding is consistent with other clinical and pre-clinical data. For instance, 4 observed that captopril, in healthy men, did not negatively impact cognitive performance on various tests but instead showed improvement in short-term memory.

However, it's important to note that some research, like 3 , demonstrated no significant negative effects of captopril on reaction time and concentration in healthy young men.

Benefits and Risks

Benefits Summary

Captopril is widely used as a treatment for high blood pressure and has proven effective in lowering blood pressure. 7 Additionally, several studies suggest its potential to improve cognitive function. 6 4

Risks Summary

Common side effects of captopril include dizziness, headache, and cough. 9 In rare cases, severe adverse effects such as kidney dysfunction and angioedema may occur. 9 Caution is advised for patients with cirrhosis, as captopril might worsen their kidney function. 9

Comparison between Studies

Commonalities

Multiple studies consistently demonstrate captopril's effectiveness in reducing blood pressure. 7 5 2 Moreover, captopril's blood pressure-lowering effect can be enhanced when combined with other antihypertensive medications. 5

Differences

Regarding cognitive function, research findings on captopril's effects vary. While some studies suggest its potential to improve cognitive function, others demonstrate no impact on cognitive performance. 6 3 4 These discrepancies could be attributed to factors such as participants' age, health status, and dosage.

Consistency and Inconsistencies in Findings

The evidence suggests that captopril is effective in treating high blood pressure. However, there is no consistent conclusion on its effects on cognitive function. Further research is needed to clarify this aspect.

Considerations for Real-Life Applications

Captopril is widely used for treating high blood pressure. It's crucial to understand the potential side effects and follow your doctor's instructions when taking this medication. Further research is required to understand how captopril might affect cognitive function.

Limitations of Current Research

Research on captopril's effects on cognitive function is still limited. Factors such as participant age, health status, and dosage might influence the research outcomes. Moreover, long-term studies are needed to better understand the long-term effects of captopril on cognitive function.

Future Research Directions

To gain a more comprehensive understanding of captopril's effects on cognitive function, large-scale, long-term studies are essential. Additionally, research should explore potential differences in captopril's effects on cognitive function based on factors such as age and health status.

Conclusion

Captopril is an effective treatment for high blood pressure. However, the effects on cognitive function remain unclear, and further research is needed. When taking captopril, it is important to follow your doctor's instructions and be aware of the potential side effects.

Literature analysis of 9 papers
Positive Content
8
Neutral Content
1
Negative Content
0
Article Type
9
0
0
0
9
1.

Quality of life in hypertensives treated with atenolol or captopril: a double-blind crossover trial.

Author: PalmerA J, FletcherA E, RudgeP J, AndrewsC D, CallaghanT S, BulpittC J

Captopril and atenolol did not significantly differ in their effects on the quality of life of hypertensive patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

[Captopril + hydrochlorothiazide versus captopril + nifedipine in the treatment of arterial hypertension in diabetes mellitus type II].

Author: Souvirón RodríguezA, Martínez MorilloM

Effective treatment
Improved glucose tolerance
Reduced renal insufficiency

Captopril was found to be an effective treatment for hypertension in diabetic patients. It lowered blood pressure without inducing metabolic changes, improving glucose tolerance and slowing the progression of renal insufficiency.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

3.

[Psychotropic effects of captopril? Effect of a short-term treatment on reaction and concentration capabilities and space perception ability].

Author: RüddelH, Napp-ZinnL, SchächingerH, MayH, LangewitzW

No negative effects

Captopril did not have any negative effects on cognitive function in healthy normotensive young men.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

4.

Central effects of the angiotensin-converting enzyme inhibitor, captopril. I. Performance and subjective assessments of mood.

Author: CurrieD, LewisR V, McDevittD G, NicholsonA N, WrightN A

Improved letter cancellation
Improved short-term memory

Captopril does not impair performance or mood in healthy subjects and may be a suitable treatment for hypertensive patients engaged in skilled activity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Captopril: contrasting effects of adding hydrochlorothiazide, propranolol, or nifedipine.

Author: MacGregorG A, MarkanduN D, SmithS J, SagnellaG A

Reduced blood pressure

Captopril is less effective in patients with essential hypertension and low renin and angiotensin levels. Its effectiveness can be increased with sodium restriction, diuretics, and nifedipine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Angiotensin converting enzyme and memory: preclinical and clinical data.

Author: SudilovskyA, TurnbullB, CroogS H, CrookT

Improved cognitive performance
Mental acuity

ACE inhibitors may improve cognitive function beyond their blood pressure lowering effects. Captopril showed better cognitive performance compared to propranolol or methyldopa. Further research suggests that ACE inhibition might reduce AII formation, leading to improved cognitive function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Captopril and opiate antagonism in essential hypertension.

Author: AjayiA A, RubinP C, ReidJ L

Naloxone did not modify the circulatory effects of captopril in patients who had been taking captopril for 2-25 months. This finding suggests that the antihypertensive effects of captopril are not significantly mediated by endogenous opioids in the long term.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Evidence of parasympathetic activity of the angiotensin converting enzyme inhibitor, captopril, in normotensive man.

Author: CampbellB C, SturaniA, ReidJ L

Blood Pressure Reduction

Captopril reduces blood pressure without increasing heart rate. It may have a parasympathetic effect contributing to its haemodynamic profile.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Effects of low-dose captopril on renal hemodynamics and function in patients with cirrhosis of the liver.

Author: GentiliniP, RomanelliR G, La VillaG, MaggioreQ, PesciullesiE, CappelliG, Casini RaggiV, FoschiM, MarraF, PinzaniM

Cirrhosis treatment
Renal dysfunction

Captopril is a drug that can have negative effects on kidney function in patients with cirrhosis and ascites. A study using low doses of captopril found that it did not affect blood pressure, suggesting that it may be a safe option for treating these patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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